Iryna Bohovych
YOU?
Author Swipe
View article: Mdm38/LETM1 couples ion homeostasis and proteostatic mechanisms in the inner mitochondrial membrane
Mdm38/LETM1 couples ion homeostasis and proteostatic mechanisms in the inner mitochondrial membrane Open
The mitochondrial inner membrane is among the most protein-dense cellular membranes. Its functional integrity is maintained through a concerted action of several conserved mechanisms that are far from clear. Here, using the baker’s yeast m…
View article: Abstract 1569 Elucidating the role of disease-associated mitochondrial factor Mdm38/LETM1
Abstract 1569 Elucidating the role of disease-associated mitochondrial factor Mdm38/LETM1 Open
Mitochondria, the "powerhouse of the cell," are complex, highly dynamic organelles that rely on multilayered maintenance machinery for sustained functioning. One such mechanism includes ion exchange processes necessary for proper mitochond…
View article: Glucose-enhanced oxidative stress resistance—A protective anticipatory response that enhances the fitness of Candida albicans during systemic infection
Glucose-enhanced oxidative stress resistance—A protective anticipatory response that enhances the fitness of Candida albicans during systemic infection Open
Most microbes have developed responses that protect them against stresses relevant to their niches. Some that inhabit reasonably predictable environments have evolved anticipatory responses that protect against impending stresses that are …
View article: Mitochondrial Contact Site and Cristae Organizing System (MICOS) Machinery Supports Heme Biosynthesis by Enabling Optimal Performance of Ferrochelatase
Mitochondrial Contact Site and Cristae Organizing System (MICOS) Machinery Supports Heme Biosynthesis by Enabling Optimal Performance of Ferrochelatase Open
Heme is an essential cofactor required for a plethora of cellular processes in eukaryotes. In metazoans the heme biosynthetic pathway is typically partitioned between the cytosol and mitochondria, with the first and final steps taking plac…
View article: Mitochondrial–nuclear heme trafficking in budding yeast is regulated by GTPases that control mitochondrial dynamics and ER contact sites
Mitochondrial–nuclear heme trafficking in budding yeast is regulated by GTPases that control mitochondrial dynamics and ER contact sites Open
Heme is a cofactor and signaling molecule that is essential for much of aerobic life. All heme-dependent processes in eukaryotes require that heme is trafficked from its site of synthesis in the mitochondria to hemoproteins located through…
View article: The heme biosynthetic enzyme, 5-aminolevulinic acid synthase (ALAS), and GTPases in control of mitochondrial dynamics and ER contact sites, regulate heme mobilization to the nucleus
The heme biosynthetic enzyme, 5-aminolevulinic acid synthase (ALAS), and GTPases in control of mitochondrial dynamics and ER contact sites, regulate heme mobilization to the nucleus Open
Heme is an iron-containing cofactor and signaling molecule that is essential for much of aerobic life. All heme-dependent processes in eukaryotes require that heme is trafficked from its site of synthesis in the mitochondria to hemoprotein…
View article: Redox Regulation of the Mitochondrial Quality Control Protease Oma1
Redox Regulation of the Mitochondrial Quality Control Protease Oma1 Open
Aims: Normal mitochondrial function and integrity are crucial for cellular physiology. Given the paramount role of mitochondrial quality control proteases in these processes, our study focused on investigating mechanisms by which the activ…
View article: Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2
Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2 Open
Mitochondria underpin metabolism, bioenergetics, signalling, development and cell death in eukaryotes. Most of the ~1,000 yeast mitochondrial proteins are encoded in the nucleus and synthesised as precursors in the cytosol, with mitochondr…
View article: Sending Out an SOS: Mitochondria as a Signaling Hub
Sending Out an SOS: Mitochondria as a Signaling Hub Open
Normal cellular physiology is critically dependent on numerous mitochondrial activities including energy conversion, cofactor and precursor metabolite synthesis, and regulation of ion and redox homeostasis. Advances in mitochondrial resear…
View article: Oma1 Links Mitochondrial Protein Quality Control and TOR Signaling To Modulate Physiological Plasticity and Cellular Stress Responses
Oma1 Links Mitochondrial Protein Quality Control and TOR Signaling To Modulate Physiological Plasticity and Cellular Stress Responses Open
A network of conserved proteases known as the intramitochondrial quality control (IMQC) system is central to mitochondrial protein homeostasis and cellular health. IMQC proteases also appear to participate in establishment of signaling cue…
View article: <i>hsp21</i>Δ/Δ exhibits reduced invasive growth and hyphal formation.
<i>hsp21</i>Δ/Δ exhibits reduced invasive growth and hyphal formation. Open
(A) Formation of hyphae was induced by embedding fungal cells in YPS (2% saccharose) agar or by plating them on solid water agar supplemented with 10% fetal bovine serum, SLAD agar or on solid Spider medium. Serum agar plates were incubate…
View article: Osmotic stress bypasses the Hsp21-dependent thermal stress tolerance.
Osmotic stress bypasses the Hsp21-dependent thermal stress tolerance. Open
Simultaneous osmotic and thermal stress lead to growth of the heat-sensitive hsp21Δ/Δ mutant. (A) Drop test analysis with serial dilutions of C. albicans wild type (Wt), hsp21Δ/Δ mutant and hsp21Δ/Δ::HSP21 complemented mutant on SD agar or…
View article: Correction for Sandai et al., The Evolutionary Rewiring of Ubiquitination Targets Has Reprogrammed the Regulation of Carbon Assimilation in the Pathogenic Yeast Candida albicans
Correction for Sandai et al., The Evolutionary Rewiring of Ubiquitination Targets Has Reprogrammed the Regulation of Carbon Assimilation in the Pathogenic Yeast Candida albicans Open
FIG 8 Addition of a consensus ubiquitin site stimulates glucose-accelerated degradation of CaIcl1 in C. albicans.(B) The carboxy-terminal ubiquitination site from ScIcl1 was fused to CaIcl1 to create CaIcl1-Ubi-Myc in C. albicans DSC04 (Ta…
View article: Metalloprotease OMA1 Fine-tunesMitochondrial BioenergeticFunction and RespiratorySupercomplex Stability
Metalloprotease OMA1 Fine-tunesMitochondrial BioenergeticFunction and RespiratorySupercomplex Stability Open
Mitochondria are involved in key cellular functions including energy production, metabolic homeostasis, and apoptosis. Normal mitochondrial function is preserved by several interrelated mechanisms. One mechanism – intramitochondrial qualit…