Iryna Hlushchenko
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View article: A-231 A novel assay measuring leukocyte lipid uptake and storage for treatment optimization in dyslipidemia and cardiovascular risk assessment
A-231 A novel assay measuring leukocyte lipid uptake and storage for treatment optimization in dyslipidemia and cardiovascular risk assessment Open
Background Elevated blood cholesterol, especially in the form of low-density lipoprotein cholesterol (LDL-C) is causing atherosclerotic cardiovascular c disease, one of the most common causes of death worldwide. Despite the availability of…
View article: Linking Variability of Leukocyte Lipid Metabolism to Circulating Lipids, Lipoprotein Composition, and Cardiovascular Risk in the Finnish Adult Population
Linking Variability of Leukocyte Lipid Metabolism to Circulating Lipids, Lipoprotein Composition, and Cardiovascular Risk in the Finnish Adult Population Open
BACKGROUND: Interindividual differences in outcomes of lipid-lowering therapy are well known. Here, we aimed to characterize how alterations in cellular lipid uptake, storage, and utilization pathways may contribute to different treatment …
View article: Large-Scale Functional Characterization of Low-Density Lipoprotein Receptor Gene Variants Improves Risk Assessment in Cardiovascular Disease
Large-Scale Functional Characterization of Low-Density Lipoprotein Receptor Gene Variants Improves Risk Assessment in Cardiovascular Disease Open
Limited access to functional information of genetic variants reduces the applicability of genetic tools for precision medicine applications in cardiovascular disease. We established an automated analysis platform based on multiplexed high-…
View article: Large-scale functional characterization of low-density lipoprotein receptor gene variants improves risk assessment in cardiovascular disease
Large-scale functional characterization of low-density lipoprotein receptor gene variants improves risk assessment in cardiovascular disease Open
Aims Lack of functional information for low-density lipoprotein (LDL) receptor (LDLR) mutations limits the use of genetics for early diagnosis, risk assessment and clinical decision making in familial hypercholesterolemia (FH). The goal of…
View article: Linking cellular lipid trafficking profiles of individuals to the outcomes of cholesterol-lowering therapy in the general population
Linking cellular lipid trafficking profiles of individuals to the outcomes of cholesterol-lowering therapy in the general population Open
View article: Functional analysis of LDLR variants using automated systems to improve rare-variant association studies and risk assessment in hypercholesterolemia
Functional analysis of LDLR variants using automated systems to improve rare-variant association studies and risk assessment in hypercholesterolemia Open
View article: Linking biological variation to outcomes of statin treatment in the general population
Linking biological variation to outcomes of statin treatment in the general population Open
Interindividual differences for outcomes of lipid-lowering therapy are well known. Alterations in cellular pathways may contribute to the phenomenon. To address this question, we employed an automated multiplexed analysis pipeline to syste…
View article: Linking cellular lipid metabolism profiles to the outcomes of cholesterol-lowering therapy in a general population cohort study
Linking cellular lipid metabolism profiles to the outcomes of cholesterol-lowering therapy in a general population cohort study Open
View article: Multiparametric platform for profiling lipid trafficking in human leukocytes
Multiparametric platform for profiling lipid trafficking in human leukocytes Open
View article: Low-Density Lipoprotein Internalization, Degradation and Receptor Recycling Along Membrane Contact Sites
Low-Density Lipoprotein Internalization, Degradation and Receptor Recycling Along Membrane Contact Sites Open
Low-density lipoprotein (LDL) internalization, degradation, and receptor recycling is a fundamental process underlying hypercholesterolemia, a high blood cholesterol concentration, affecting more than 40% of the western population. Membran…
View article: Molecular Mechanisms and Physiological Significance of Organelle Interactions and Cooperation - Volume II
Molecular Mechanisms and Physiological Significance of Organelle Interactions and Cooperation - Volume II Open
Eukaryotic cells contain distinct membrane-bound organelles, which compartmentalize cellular proteins to fulfil a variety of vital functions. In contrast to being isolated and static entities (e.g., peroxisomes, mitochondria, lipid droplet…
View article: MIM-Deficient Mice Exhibit Anatomical Changes in Dendritic Spines, Cortex Volume and Brain Ventricles, and Functional Changes in Motor Coordination and Learning
MIM-Deficient Mice Exhibit Anatomical Changes in Dendritic Spines, Cortex Volume and Brain Ventricles, and Functional Changes in Motor Coordination and Learning Open
In this study, we performed a comprehensive behavioral and anatomical analysis of the Missing in Metastasis (Mtss1/MIM) knockout (KO) mouse brain. We also analyzed the expression of MIM in different brain regions at different ages. MIM is …
View article: Chemical LTD, but not LTP, induces transient accumulation of gelsolin in dendritic spines
Chemical LTD, but not LTP, induces transient accumulation of gelsolin in dendritic spines Open
Synaptic plasticity underlies central brain functions, such as learning. Ca2+ signaling is involved in both strengthening and weakening of synapses, but it is still unclear how one signal molecule can induce two opposite outcomes. By ident…
View article: Actin regulation in dendritic spines: From synaptic plasticity to animal behavior and human neurodevelopmental disorders
Actin regulation in dendritic spines: From synaptic plasticity to animal behavior and human neurodevelopmental disorders Open
This thesis explores the role of several actin-binding proteins in the regulation of brain physiology with a focus on dendritic spines. Dendritic spines are considered the plausible physical substrate for learning and memory, as their morp…
View article: Chemical LTD, but not LTP, induces transient accumulation of gelsolin in dendritic spines
Chemical LTD, but not LTP, induces transient accumulation of gelsolin in dendritic spines Open
Synaptic plasticity underlies central brain functions, such as learning. Ca 2+ signaling is involved in both strengthening and weakening of synapses, but it is still unclear how one signal molecule can induce two opposite outcomes. By iden…
View article: ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons
ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons Open
Many actin cytoskeleton-regulating proteins control dendritic spine morphology and density, which are cellular features often altered in autism spectrum disorder (ASD). Recent studies using animal models show that autism-related behavior c…