Iryna Kril
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APOPTOTIC INTERACTIONS IN LONG COVID AND AGING Open
Aging is a natural process that engages all the body’s systems and tissues. Aging leads to chronic inflammation, contributing to the overall aging process. A persistently activated immune system becomes pro-inflammatory, contributing to ag…
T-REGULATORY LYMPHOCYTES IN PATIENTS WITH ANTIBODY DEFICIENCY AND MANIFESTATIONS OF SECONDARY SYSTEMIC VASCULITIS Open
The review focused on analyzing clinical and immunological peculiarities in patients with common variable immunodeficiency, with and without manifestations of secondary systemic vasculitis. CVID is a primary immunodeficiency marked by quan…
IMMUNE SYSTEM DISTANT EFFECTS IN PATIENTS WITH LONG-COVID ON THE BACKGROUND OF REACTIVATION HHV-6 INFECTION Open
Introduction. It is now known that 30% of patients who have recovered from COVID-19 develop long-COVID. According to researchers, the reactivation of herpesviruses plays a significant role in triggering long-COVID. In these patients, alter…
Association of ERAP1 and ERAP2 gene polymorphisms and ERAP2 protein with the susceptibility and severity of rheumatoid arthritis in the Ukrainian population Open
Introduction Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. Although RA is chiefly associated with HLA class II, nevertheless some HLA class I associations have also been observed. These molecul…
POST-COVID EFFECTS AND IMMUNOLOGICAL MARKERS OF AGING Open
The coronavirus disease has challenged the global medical community. Its progression led to severe health and life consequences, resulting in prolonged complications following the onset of the acute phase of the disease. The immune system …
Changes in the cytotoxic and regulatory functions of NK cells in patients with long-COVID under the influence of the human herpesvirus 6 (pilot study) Open
Long-COVID are often accompanied by the development of autoimmun disorders. Such dysregulation of the immune system can be caused by reactivation of "sluggish" herpesvirus infection in patients after COVID-19. The one of the possible cause…
STUDY OF THE EFFECTIVENESS OF IMMUNOTROPIC THERAPY OF LONG-COVID-19 PATIENTS WITH TYPE 6 OF HUMAN HERPES VIRUS REACTIVATION Open
Introduction. After the acute form of COVID-19, 10 to 30% of patients tend to develop a post-covid syndrome or long-COVID-19. Research is actively being conducted into the causes of long-term COVID-19, one of which may be a violation of th…
POST-TRAUMATIC STRESS DISORDER: СLINICAL AND LABORATORY CHANGES AND POTENTIAL FOR IMMUNE DISORDERS Open
Background. The spread of post-traumatic stress disorder (PTSD) and overcoming its consequences, including immune-related disorders, is one of the critical issues requiring extensive study and resolution in practical medicine, particularly…
Low Level of Advanced Glycation End Products in Serum of Patients with Allergic Rhinitis and Chronic Epstein-Barr Virus Infection at Different Stages of Virus Persistence Open
Advanced glycation end products (AGEs) are formed in a nonenzymatic reaction of the reducing sugars with amino groups of proteins, lipids, and nucleic acids of different tissues and body fluids. A relatively small number of studies have be…
RELATIONSHIP OF APOPTOSIS AND SECONDARY NECROSIS OF LEUCOCYTES WITH ACTIVITY OF DISEASE AND CLINICAL MANIFESTATION IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS Open
The presence of several different autoantibodies (auto-AT) at the same time is a specific peculiarity of the "autoantibody profile" of SLE (systemic lupus erythematosus). It is known that the induction of auto-AT formation involves both no…
View article: Reduction in viability oh human cervix carcinoma HeLa cells by p21 gene transferred with block polymeric dimethylaminoethyl methacrylate-based carrier
Reduction in viability oh human cervix carcinoma HeLa cells by p21 gene transferred with block polymeric dimethylaminoethyl methacrylate-based carrier Open
Background. Various cationic polymers have been proposed for use as carriers of genetic materials in biotechnology and biomedicine. The poly(2-dimethylamino)ethyl-methacrylate (poly(DMAEMA)) demonstrated high transfection efficiency and lo…
ANAMNESTIC, CLINICAL AND LABORATORY DATA ANALYSIS OF PATIENTS FOR DRUG HYPERSENSITIVITY REACTIONS Open
The current development of the pharmaceutical industry in the synthesis of new chemical compounds, standardized treatment protocols, and disease prevention can lead to a progressive increase in drug hypersensitivity reactions, which often …
Аdvanced glycation end-products as novel biomarkers of eosinophil-derived lung inflammatory diseases (literature review) Open
Advanced glycation end-products (AGEs) are created during the process of glycation of cells from various tissues and fluids and are a heterogeneous group of molecules formed from the nonenzymatic reaction of reducing sugars with the amino …
CYTOKINE PROFILE IN PATIENTS WITH REACTIVE ARTНRITIS CAUSED BY EPSTEIN-BARR VIRAL AND CHLAMYDIAL INFECTIONS Open
Вступ. Реактивний артрит – найпоширеніше захворювання суглобів серед осіб працездатного віку. Запальний процес виникає не лише у разі бактерійної інфекції (урогенітальній, кишковій чи респіраторній), але спричиняється і вірусами (віруси ге…
Phagocytic activity of neutrophils and monocytes in patients with reactive artнritis caused by Epstein-Barr viral and Chlamydial infections Open
Aim. To identify the state of phagocytic and oxidative activity of phagocytes in the blood in patients with reactive arthritis caused by chlamydia and viral infections. Material and Methods. The investigation involved 97 patients with reac…
4-Thiazolidinone derivative Les-3833 effectively inhibits viability of human melanoma cells through activating apoptotic mechanisms Open
Novel 4-thiazolidinone derivative Les-3833 is effective against human melanoma cells in vitro, and such effect is tumor specific since it is much less pronounced in human carcinoma and leukemia cells. In melanoma cells Les-3833 induces apo…
CCDC 1432661: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …