Explanipedia

Deciphering brain organoid heterogeneity by identifying key quality determinants Open

Tom Boerstler, Daniel V. Kachkin, Elizaveta Gerasimova, Naime Zagha, Federica Furlanetto , et al. · 2025

TNF-<i>α</i>disrupts the malate-aspartate shuttle, driving metabolic rewiring in iPSC-derived enteric neural lineages from Parkinson’s Disease patients Open

Bruno Ghirotto, Luis Eduardo Duarte Gonçalves, Vivien Ruder, Christina James, Elizaveta Gerasimova , et al. · 2025

Gastrointestinal (GI) dysfunction emerges years before motor symptoms in Parkinson’s disease (PD), implicating the enteric nervous system (ENS) in early disease progression. However, the mechanisms linking the PD hallmark protein, α-synucl…

Novel co-culture model of T cells and midbrain organoids for investigating neurodegeneration in Parkinson’s disease Open

Elizaveta Gerasimova, Amke C. Beenen, Daniil Kachkin, Martin Regensburger, Sebastian Zundler , et al. · 2025

Recent studies demonstrate that brain infiltration of peripheral immune cells and their interaction with brain-resident cells contribute to Parkinson’s disease (PD). However, mechanisms of T cell-brain cell communication are not fully eluc…

NPT100-18A rescues mitochondrial oxidative stress and neuronal degeneration in human iPSC-based Parkinson’s model Open

Julian E. Alecu, Veronika Sigutova, Razvan-Marius Brazdis, Sandra Lörentz, Marios Bogiongko , et al. · 2025

Background Parkinson’s disease (PD) is a neurodegenerative disorder characterized by protein aggregates mostly consisting of misfolded alpha-synuclein (αSyn). Progressive degeneration of midbrain dopaminergic neurons (mDANs) and nigrostria…

Novel Co-culture Model of T Cells and Midbrain Organoids for Investigating Neurodegeneration in Parkinson's Disease Open

Iryna Prots, Elizaveta Gerasimova, Amke C. Beenen, Daniil Kachkin, Martin Regensburger , et al. · 2024

Recent studies demonstrate that brain infiltration of peripheral immune cells and their interaction with brain-resident cells contribute to Parkinson’s disease (PD) pathology. To investigate an interaction of T cells and brain-resident cel…

An Enhanced Retroviral Vector for Efficient Genetic Manipulation and Selection in Mammalian Cells Open

Jana Triller, Iryna Prots, Hans‐Martin Jäck, Jürgen Wittmann · 2024

Introducing genetic material into hard-to-transfect mammalian cell lines and primary cells is often best achieved through retroviral infection. An ideal retroviral vector should offer a compact, selectable, and screenable marker while maxi…

Alpha-synuclein fine-tunes neuronal response to pro-inflammatory cytokines Open

Veronika Sigutova, Wei Xiang, Martin Regensburger, Beate Winner, Iryna Prots · 2024

Pro-inflammatory cytokines are emerging as neuroinflammatory mediators in Parkinson's disease (PD) due to their ability to act through neuronal cytokine receptors. Critical questions persist regarding the role of cytokines in neuronal dysf…

NPT100-18A rescues mitochondrial oxidative stress and neuronal loss in human iPSC-based Parkinson's model Open

Julian E. Alecu, Veronika Sigutova, Razvan-Marius Brazdis, Sandra Lörentz, Marios Bogionko , et al. · 2024

Background Parkinson’s disease (PD) is a neurodegenerative disorder characterized by protein aggregates mostly consisting of misfolded alpha-synuclein (αSyn). Progressive degeneration of midbrain dopaminergic neurons (mDANs) and nigrostria…

NPT100-18A reduces mitochondrial oxidative stress and rescues neuronal cell death in a human iPSC-based model of Parkinson’s disease Open

Julian E. Alecu, Veronika Sigutova, Razvan-Marius Brazdis, Sandra Loerentz, Marios Bogionko , et al. · 2023

Background Parkinson’s disease (PD) is a neurodegenerative disorder characterized by protein aggregates mostly consisting of misfolded alpha-synuclein (αSyn). Progressive degeneration of midbrain dopaminergic neurons (mDANs) and nigrostria…

IL-3 receptor signalling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory T cells Open

Karen A.-M. Ullrich, J Derdau, Carsten Baltes, Alice Battistella, Gonzalo Rosso , et al. · 2023

IL-3 has been reported to be involved in various inflammatory disorders, but its role in inflammatory bowel disease (IBD) has not been addressed so far. Here, we determined IL-3 expression in samples from patients with IBD and studied the …

P009 IL-3 receptor signalling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory T cells Open

Karen A.-M. Ullrich, J Derdau, Carsten Baltes, Gonzalo Rosso, Stefan Uderhardt , et al. · 2023

Background The pathogenesis of inflammatory bowel diseases (IBD) such as Crohn’s disease (CD) and ulcerative colitis (UC) is still incompletely understood. However, despite having been described back in the 1980s and reported to be involve…

Translocation of Distinct Alpha Synuclein Species from the Nucleus to Neuronal Processes during Neuronal Differentiation Open

Katharina Pieger, Verena Schmitt, Carina Gauer, Nadja Gießl, Iryna Prots , et al. · 2022

Alpha synuclein (aSyn) and its aggregation are crucial for the neurodegeneration of Parkinson’s disease (PD). aSyn was initially described in the nucleus and presynaptic nerve terminals. However, the biology of nuclear aSyn and the link of…

The Quest for Anti-α-Synuclein Antibody Specificity—Lessons Learnt From Flow Cytometry Analysis Open

Lukas Leupold, Veronika Sigutova, Elizaveta Gerasimova, Martin Regensburger, Sebastian Zundler , et al. · 2022

The accumulation of alpha-synuclein (aSyn) is the hallmark of a group of neurodegenerative conditions termed synucleopathies. Physiological functions of aSyn, including those outside of the CNS, remain elusive. However, a reliable and repr…

Interaction of Alpha Synuclein and Microtubule Organization Is Linked to Impaired Neuritic Integrity in Parkinson’s Patient-Derived Neuronal Cells Open

Lukas Seebauer, Yanni Schneider, Alice Drobny, Sonja Plötz, Tomas Koudelka , et al. · 2022

Parkinson’s disease (PD) is neuropathologically characterized by the loss of dopaminergic neurons and the deposition of aggregated alpha synuclein (aSyn). Mounting evidence suggests that neuritic degeneration precedes neuronal loss in PD. …

Axon-Specific Mitochondrial Pathology in SPG11 Alpha Motor Neurons Open

Fabian Güner, Tatyana Pozner, Florian Krach, Iryna Prots, Sandra Loskarn , et al. · 2021

Pathogenic variants in SPG11 are the most frequent cause of autosomal recessive complicated hereditary spastic paraplegia (HSP). In addition to spastic paraplegia caused by corticospinal degeneration, most patients are significantly affect…

Unique signatures of stress-induced senescent human astrocytes Open

Katrin Simmnacher, Florian Krach, Yanni Schneider, Julian E. Alecu, Lena Mautner , et al. · 2020

Senescence was recently linked to neurodegeneration and astrocytes are one of the major cell types to turn senescent under neurodegenerative conditions. Senescent astrocytes were detected in Parkinson's disease (PD) patients' brains beside…

Author Correction: A monocyte gene expression signature in the early clinical course of Parkinson’s disease Open

Johannes C. M. Schlachetzki, Iryna Prots, Jenhan Tao, Hyun Bae Chun, Kaoru Saijo , et al. · 2020

Demonstration of brain region-specific neuronal vulnerability in human iPSC-based model of familial Parkinson’s disease Open

Razvan-Marius Brazdis, Julian E. Alecu, Daniel Marsch, Annika Dahms, Katrin Simmnacher , et al. · 2020

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by protein inclusions mostly composed of aggregated forms of α-synuclein (α-Syn) and by the progressive degeneration of midbrain dopaminergic neurons (mDANs), resulting…

Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson’s Disease Open

Annika Sommer, Franz Marxreiter, Florian Krach, Tanja Fadler, Janina Grosch , et al. · 2019

A monocyte gene expression signature in the early clinical course of Parkinson’s disease Open

Johannes C. M. Schlachetzki, Iryna Prots, Jenhan Tao, Hyun Bae Chun, Kaoru Saijo , et al. · 2018

α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies Open

Iryna Prots, Janina Grosch, Razvan-Marius Brazdis, Katrin Simmnacher, Vanesa Veber , et al. · 2018

Significance α-Synuclein (α-Syn) aggregation underlies neurodegeneration in synucleinopathies. However, the nature of α-Syn aggregates and their toxic mechanisms in human pathology remains elusive. Here, we delineate a role of α-Syn oligom…

Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson’s Disease Open

Annika Sommer, Franz Marxreiter, Florian Krach, Tanja Fadler, Janina Grosch , et al. · 2018

Impact of Swiprosin-1/Efhd2 on Adult Hippocampal Neurogenesis Open

Martin Regensburger, Iryna Prots, Dorothea Reimer, Sebastian Brachs, Sandra Loskarn , et al. · 2018

Swiprosin-1/Efhd2 (Efhd2) is highly expressed in the CNS during development and in the adult. EFHD2 is regulated by Ca2+ binding, stabilizes F-actin, and promotes neurite extension. Previous studies indicated a dysregulation of EFHD2 in hu…

The Trojan horse - neuroinflammatory impact of T cells in neurodegenerative diseases Open

Annika Sommer, Beate Winner, Iryna Prots · 2017

Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress Open

Stefanie Menges, Georgia Minakaki, Patrick M. Schaefer, H Meixner, Iryna Prots , et al. · 2017

Oxidative stress (OS), mitochondrial dysfunction, and dysregulation of alpha-synuclein (aSyn) homeostasis are key pathogenic factors in Parkinson’s disease. Nevertheless, the role of aSyn in mitochondrial physiology remains elusive. Thus, …

Infiltrating T lymphocytes reduce myeloid phagocytosis activity in synucleinopathy model Open

Annika Sommer, Tanja Fadler, Eva Dorfmeister, Anna-Carin Hoffmann, Wei Xiang , et al. · 2016

Issue Information – Table of Contents Open

Roy H. Hamilton, Estefan Ia, Ruiz De Vargas, Peter S€ Or€ Os, J. Kevin Shoemaker , et al. · 2016

A 3D model of a canonical GABA-A receptor as seen from the synaptic cleft.It is composed of five subunits, two alpha (gray), two beta (blue) and one gamma (yellow).The central pore is permeable to chloride ions when the receptor channel is…

GSK3ß‐dependent dysregulation of neurodevelopment in SPG11‐patient induced pluripotent stem cell model Open

Himanshu Mishra, Iryna Prots, Steven Havlicek, Zacharias Kohl, Francesc Pérez-Brangulı́ , et al. · 2016

Objective Mutations in the spastic paraplegia gene 11 (SPG11), encoding spatacsin, cause the most frequent form of autosomal‐recessive complex hereditary spastic paraplegia (HSP) and juvenile‐onset amyotrophic lateral sclerosis (ALS5). Whe…

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