Isa Murrell
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View article: Virion proteomics of genetically intact HCMV reveals a regulator of envelope glycoprotein composition that protects against humoral immunity
Virion proteomics of genetically intact HCMV reveals a regulator of envelope glycoprotein composition that protects against humoral immunity Open
Human cytomegalovirus (HCMV) is a clinically important herpesvirus that has coevolved for millions of years with its human host, and establishes lifelong persistent infection. A substantial proportion of its 235 kb genome is dedicated to m…
View article: Virion Proteomics of Genetically Intact HCMV Reveals a Novel Regulator of Envelope Glycoprotein Composition that Protects Against Humoral Immunity
Virion Proteomics of Genetically Intact HCMV Reveals a Novel Regulator of Envelope Glycoprotein Composition that Protects Against Humoral Immunity Open
Human cytomegalovirus (HCMV) is a clinically important herpesvirus that has co-evolved for millions of years with its human host, and establishes lifelong persistent infection. A substantial proportion of its 235kb genome is dedicated to m…
View article: Higher Relative Viral Load Excretion Determined by Normalised Threshold Crossing Value in Acute Cases infected with the B.1.1.7 Lineage VOC 202012/01 (Using S gene target failure as a Proxy) When Compared to other Circulating Lineages in Wales
Higher Relative Viral Load Excretion Determined by Normalised Threshold Crossing Value in Acute Cases infected with the B.1.1.7 Lineage VOC 202012/01 (Using S gene target failure as a Proxy) When Compared to other Circulating Lineages in Wales Open
Since the emergence of SARS-CoV-2, global monitoring of the virus using whole genome sequencing has identified mutations occurring across the viral genome. Whilst the majority have little impact on the virus, they are used effectively to m…
View article: Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus
Monoclonal antibodies targeting nonstructural viral antigens can activate ADCC against human cytomegalovirus Open
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that causes severe disease following congenital infection and in immunocompromised individuals. No vaccines are licensed, and there are limited treatment options. We now show that the a…
View article: Temporal development and neutralising potential of antibodies against SARS-CoV-2 in hospitalised COVID-19 patients: An observational cohort study
Temporal development and neutralising potential of antibodies against SARS-CoV-2 in hospitalised COVID-19 patients: An observational cohort study Open
Antibody responses are important in the control of viral respiratory infection in the human host. What is not clear for SARS-CoV-2 is how rapidly this response occurs, or when antibodies with protective capability evolve. Hence, defining t…
View article: A longitudinal comparison of spike and nucleocapsid SARS-CoV-2 antibody responses in a tertiary hospital’s laboratory workers with validation of DBS specimen analysis
A longitudinal comparison of spike and nucleocapsid SARS-CoV-2 antibody responses in a tertiary hospital’s laboratory workers with validation of DBS specimen analysis Open
There is a requirement for easily accessible, high throughput serological testing as part of the SARS-CoV-2 pandemic response. Whilst of limited diagnostic use in an acute individual setting, its use on a population level is key to informi…
View article: Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses
Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses Open
Significance Human cytomegalovirus (HCMV) is the major infectious cause of developmental disorders in babies due to its capacity to cross the placenta. HCMV is also a major pathogen in transplant recipients and HIV–AIDS patients. Despite i…
View article: The pentameric complex drives immunologically covert cell–cell transmission of wild-type human cytomegalovirus
The pentameric complex drives immunologically covert cell–cell transmission of wild-type human cytomegalovirus Open
Significance Strains of human cytomegalovirus (HCMV) that have been passaged in the laboratory fail to recapitulate the phenotypic characteristics of ex vivo isolates due to the rapid acquisition of genetic mutations. In particular, clinic…
View article: Genetic Stability of Bacterial Artificial Chromosome-Derived Human Cytomegalovirus during Culture <i>In Vitro</i>
Genetic Stability of Bacterial Artificial Chromosome-Derived Human Cytomegalovirus during Culture <i>In Vitro</i> Open
Clinical human cytomegalovirus (HCMV) strains invariably mutate when propagated in vitro . Mutations in gene RL13 are selected in all cell types, whereas in fibroblasts mutants in the UL128 locus (UL128L; genes UL128, UL130, and UL131A) ar…