Isa Naina Mohamed
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View article: The Acceptability of Implanon in Muslim-Majority Asian Countries: A Systematic Review
The Acceptability of Implanon in Muslim-Majority Asian Countries: A Systematic Review Open
Background: We conducted a systematic review which aimed to assess acceptability of implanon used based on reported side effects, continuation rates and user satisfaction in Muslim-majority Asian countries. Methods: We followed PRISMA guid…
View article: The canonical Wnt pathway in osteoporosis: a scoping review of key compounds and proteins modulating Wnt-induced osteogenesis
The canonical Wnt pathway in osteoporosis: a scoping review of key compounds and proteins modulating Wnt-induced osteogenesis Open
Purpose The canonical Wnt pathway—a key regulator of bone formation and remodeling—has emerged as a promising target for osteoporosis therapy. This scoping review aims to map the key compounds and proteins modulating Wnt-induced osteogenes…
View article: Encapsulated oil palm phenolics lower blood pressure and improve antioxidant status in healthy adults: a phase one trial
Encapsulated oil palm phenolics lower blood pressure and improve antioxidant status in healthy adults: a phase one trial Open
View article: Bioactive Potential and In Silico Insights of Flavonoid-Enriched Femivine V Jelly and Kaempferia Angustifolia Extracts in Antioxidant and Anticancer Applications
Bioactive Potential and In Silico Insights of Flavonoid-Enriched Femivine V Jelly and Kaempferia Angustifolia Extracts in Antioxidant and Anticancer Applications Open
Kaempferia angustifolia, a notable medicinal herb within the ginger family, comprises around 60 species of rhizomatous plants. Commonly referred to as temu kunci, kunci pepet, or Thao Nhang Haeng in Southeast Asia, it is renowned for its a…
View article: EFFECTS OF BLAINVILLEA ACMELLA ON THE BONE MECHANICAL PROPERTIES OF OVARIECTOMIZED RATS
EFFECTS OF BLAINVILLEA ACMELLA ON THE BONE MECHANICAL PROPERTIES OF OVARIECTOMIZED RATS Open
A metabolic bone disorder known as osteoporosis is represented by low mineral bone mass and strength. Blainvillea acmella (BA), a herbal plant with antioxidant properties have exhibited anti-osteoporosis effects. The present study set out …
View article: A Systematic Review of the Potential of Acmella Genus Plants for the Treatment of Musculoskeletal Disorders
A Systematic Review of the Potential of Acmella Genus Plants for the Treatment of Musculoskeletal Disorders Open
The genus Acmella has received growing attention for its pharmacological properties, including its potential applications in musculoskeletal disorders (MSDs). Plants in this genus, such as Spilanthes acmella, Blainvillea acmella, Acmella u…
View article: Performance of direct-from-blood-culture disk diffusion antibiotic susceptibility testing and its impact on antibiotic adjustment in bloodstream infections at a Malaysian tertiary center
Performance of direct-from-blood-culture disk diffusion antibiotic susceptibility testing and its impact on antibiotic adjustment in bloodstream infections at a Malaysian tertiary center Open
Delayed antibiotics increase mortality in bloodstream infection (BSI). Direct-from-blood-culture disk diffusion antibiotic susceptibility testing (dAST) forecasts susceptibility earlier than conventional susceptibility testing (cAST). The …
View article: A Systematic Review of the Potential of <em>Acmella </em>Genus Plants for the Treatment of Musculoskeletal Disorders
A Systematic Review of the Potential of <em>Acmella </em>Genus Plants for the Treatment of Musculoskeletal Disorders Open
Background: The genus Acmella has received growing attention for its pharmacological properties, including its potential applications in musculoskeletal disorders (MSD). Plants in this genus such as Spilanthes acmella, Blainvillea acmella,…
View article: Assessment of antibiotic prescribing quality through repeated point prevalence surveys in a Malaysian teaching hospital
Assessment of antibiotic prescribing quality through repeated point prevalence surveys in a Malaysian teaching hospital Open
Introduction: Optimising antibiotic prescribing in hospitals through antimicrobial stewardship (AMS) initiatives is essential in addressing the global threat of antimicrobial resistance. Methods: Point prevalence surveys were performed in …
View article: Oil palm Phenolics supplementation improves plasma antioxidant levels and modulates inflammatory markers in individuals with minor Hyperlipidaemia: A randomized, double-blind, placebo-controlled trial
Oil palm Phenolics supplementation improves plasma antioxidant levels and modulates inflammatory markers in individuals with minor Hyperlipidaemia: A randomized, double-blind, placebo-controlled trial Open
Oil palm phenolics (OPP), an aqueous byproduct of palm oil milling, contains phenolic compounds with potential medicinal properties, including cardioprotective effects. OPP has been shown to be safe and well-tolerated in human studies. Pre…
View article: The outcomes of hybrid virtual consultation for a smoking cessation program in Klang Valley, Malaysia
The outcomes of hybrid virtual consultation for a smoking cessation program in Klang Valley, Malaysia Open
Hybrid virtual consultation was more effective, as evidenced by higher smoking cessation at week 7 (1-month post-quit date) and CAR from week 7 to week 24 compared to the face-to-face group. Telemedicine or teleconsultation should be easil…
View article: A Systematic Review on the Molecular Mechanisms of Resveratrol in Protecting Against Osteoporosis
A Systematic Review on the Molecular Mechanisms of Resveratrol in Protecting Against Osteoporosis Open
Osteoporosis is a prevalent metabolic bone disorder characterized by decreased bone mineral density and increased fracture risk, particularly among aging populations. While conventional pharmacological treatments exist, they often have adv…
View article: Network Pharmacology, Molecular Docking and Experimental Validation on Potential Application of Diabetic Wound Healing of Cinnamomum zeylanicum Through Matrix Metalloproteinases-8 And 9 (MMP-8 And MMP-9)
Network Pharmacology, Molecular Docking and Experimental Validation on Potential Application of Diabetic Wound Healing of Cinnamomum zeylanicum Through Matrix Metalloproteinases-8 And 9 (MMP-8 And MMP-9) Open
Cinnamomum zeylanicum exhibits promising potential in diabetic wound healing by modulating MMP-8 and MMP-9 activities, enhancing antioxidant defenses, and improving glucose regulation. These findings support its therapeutic applicat…
View article: Thyroid Hormones and Tobacco Use: A Case-Control Study
Thyroid Hormones and Tobacco Use: A Case-Control Study Open
The thyroid gland plays a crucial role in regulating metabolic processes through the secretion of thyroxine (T4) and triiodothyronine (T3). Tobacco use, a leading global cause of preventable mortality, has been implicated in influencing th…
View article: 10003: Proliferation and Migration Properties of Combined Squalene and Tocotrienol-Rich Fraction on Oxidized LDL-Induced Atherogenesis in Human Umbilical Vein Endothelial Cells
10003: Proliferation and Migration Properties of Combined Squalene and Tocotrienol-Rich Fraction on Oxidized LDL-Induced Atherogenesis in Human Umbilical Vein Endothelial Cells Open
View article: Prevalence and clinical significance of the genotypic carriage among ESBL phenotype-negative Escherichia coli and Klebsiella pneumoniae clinical isolates in bacteremia: a study in a Malaysian tertiary center
Prevalence and clinical significance of the genotypic carriage among ESBL phenotype-negative Escherichia coli and Klebsiella pneumoniae clinical isolates in bacteremia: a study in a Malaysian tertiary center Open
Background Antimicrobial resistance (AMR) can lead to fatal consequences. AMR genes carriage by phenotypically susceptible bacteria, such as Extended-Spectrum β-Lactamases (ESBL)s in Enterobacteriaceae , have potential implications for AMR…
View article: Evaluating the Anti-Osteoporotic Potential of Mediterranean Medicinal Plants: A Review of Current Evidence
Evaluating the Anti-Osteoporotic Potential of Mediterranean Medicinal Plants: A Review of Current Evidence Open
Background: Bones are biological reservoirs for minerals and cells, offering protection to the other organs and contributing to the structural form of the body. Osteoporosis is a prevalent bone condition that significantly impacts people’s…
View article: Development of self-administered questionnaire on barriers, prescription practices, and guideline adherence of osteoporosis management among tertiary care clinicians: content validity and reliability analysis
Development of self-administered questionnaire on barriers, prescription practices, and guideline adherence of osteoporosis management among tertiary care clinicians: content validity and reliability analysis Open
Objective This study outlined the development of the barriers, prescribing practices, and guideline adherence for osteoporosis management according to the Clinicians’ Osteoporosis Questionnaire (COQ) followed by an assessment of the conten…
View article: Locomotion changes in methamphetamine and amphetamine withdrawal: a systematic review
Locomotion changes in methamphetamine and amphetamine withdrawal: a systematic review Open
Despite extensive preclinical research over the years, a significant gap remains in our understanding of the specific effects of methamphetamine (METH) and amphetamine (AMPH) withdrawal. Understanding these differences could be pivotal to …
View article: The Effects of Acute and Chronic Alcohol Administration and Withdrawal on Bone Microstructure, Mechanical Strength, and Remodeling Protein Expression and Their Relation to an Antioxidant and FGF23 In Vivo
The Effects of Acute and Chronic Alcohol Administration and Withdrawal on Bone Microstructure, Mechanical Strength, and Remodeling Protein Expression and Their Relation to an Antioxidant and FGF23 In Vivo Open
Alcohol’s detrimental effects on bone health are well established, yet some literature suggests moderate consumption may offer benefits. With alcohol use on the rise, we investigate the impact of acute and chronic alcohol administration, a…
View article: Smoking prevalence, exposure to secondhand smoke, and factors associated with smoking among medical, dental, and pharmacy students in a public university in Malaysia
Smoking prevalence, exposure to secondhand smoke, and factors associated with smoking among medical, dental, and pharmacy students in a public university in Malaysia Open
Although smoking prevalence was low among the students in this study, there was a higher percentage of them exposed to secondhand smoke at home and in public.
View article: Metformin Hydrochloride Loaded Mucoadhesive Microspheres and Nanoparticles for Anti-Hyperglycemic and Anticancer Effects Using Factorial Experimental Design
Metformin Hydrochloride Loaded Mucoadhesive Microspheres and Nanoparticles for Anti-Hyperglycemic and Anticancer Effects Using Factorial Experimental Design Open
This study suggests that the proposed metformin HCl formulation can dramatically reduce hyperglycemic conditions and may also have anticancer potential.
View article: Safety and efficacy of oil palm phenolic supplementation in improving lipid profile among hyperlipidemic adults: a phase 2, randomized, double-blind, placebo-controlled clinical trial
Safety and efficacy of oil palm phenolic supplementation in improving lipid profile among hyperlipidemic adults: a phase 2, randomized, double-blind, placebo-controlled clinical trial Open
Introduction: Oil palm phenolic (OPP) is an antioxidant aqueous palm oil by-product and contains a high amount of phenolics. OPP has been proven to have many therapeutical benefits, and one of them is as an antihyperlipidemic agent. The pr…
View article: Alcohol Dependence Modulates Amygdalar mTORC2 and PKCε Expression in a Rodent Model
Alcohol Dependence Modulates Amygdalar mTORC2 and PKCε Expression in a Rodent Model Open
Multiple alcohol use disorder (AUD)-related behavioral alterations are governed by protein kinase C epsilon (PKCε), particularly in the amygdala. Protein kinase C (PKC) is readily phosphorylated at Ser729 before activation by the mTORC2 pr…
View article: Infertility and cortisol: a systematic review
Infertility and cortisol: a systematic review Open
Introduction Stress and infertility form a complex relationship. In line with this, various stress-related biological markers have been investigated in infertility. Methods This systematic review was performed using PRISMA guidelines (i) t…
View article: In vitro Comparative Studies of the Leaf Extracts of Four Different Types of Calamus Species
In vitro Comparative Studies of the Leaf Extracts of Four Different Types of Calamus Species Open
The leaf extracts of Calamus tenius, Calamus viminalis, Calamus guruba and Calamus erectus possessed various phytochemicals including alkaloids, carbohydrates, saponins, phenols, tannins, flavonoids, glycosides, fixed oils and steroids. Th…
View article: Antidiabetic Potential of Commonly Available Fruit Plants in Bangladesh: Updates on Prospective Phytochemicals and Their Reported MoAs
Antidiabetic Potential of Commonly Available Fruit Plants in Bangladesh: Updates on Prospective Phytochemicals and Their Reported MoAs Open
Diabetes mellitus is a life-threatening disorder affecting people of all ages and adversely disrupts their daily functions. Despite the availability of numerous synthetic-antidiabetic medications and insulin, the demand for the development…
View article: The effects of aqueous extract of Labisia Pumila (Blume) Fern.-Vill. Var. Alata on wound contraction, hydroxyproline content and histological assessments in superficial partial thickness of second-degree burn model
The effects of aqueous extract of Labisia Pumila (Blume) Fern.-Vill. Var. Alata on wound contraction, hydroxyproline content and histological assessments in superficial partial thickness of second-degree burn model Open
Background: Burns are considered a critical care problem in emergency medicine, resulting in physical, psychological, and chronic disabilities. Silver sulfadiazine is the gold standard in topical burn treatment but was associated with toxi…
View article: Plethora of Antibiotics Usage and Evaluation of Carbapenem Prescribing Pattern in Intensive Care Units: A Single-Center Experience of Malaysian Academic Hospital
Plethora of Antibiotics Usage and Evaluation of Carbapenem Prescribing Pattern in Intensive Care Units: A Single-Center Experience of Malaysian Academic Hospital Open
Excessive antibiotic consumption is still common among critically ill patients admitted to intensive care units (ICU), especially during the coronavirus disease 2019 (COVID-19) period. Moreover, information regarding antimicrobial consumpt…
View article: Ethnobotanical Uses, Phytochemistry, Toxicology, and Pharmacological Properties of Euphorbia neriifolia Linn. against Infectious Diseases: A Comprehensive Review
Ethnobotanical Uses, Phytochemistry, Toxicology, and Pharmacological Properties of Euphorbia neriifolia Linn. against Infectious Diseases: A Comprehensive Review Open
Medicinal plants have considerable potential as antimicrobial agents due to the presence of secondary metabolites. This comprehensive overview aims to summarize the classification, morphology, and ethnobotanical uses of Euphorbia neriifoli…