Isaac Dripps
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View article: Activation of δ‐opioid receptors blocks allodynia in a model of headache induced by PACAP
Activation of δ‐opioid receptors blocks allodynia in a model of headache induced by PACAP Open
Background and purpose Pituitary adenylate cyclase activating polypeptide (PACAP) is a human migraine trigger that is being targeted for migraine. The δ‐opioid receptor (δ‐receptor) is a novel target for the treatment of migraine, but its …
View article: Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition
Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition Open
Migraine is the sixth most prevalent disease worldwide but the mechanisms that underlie migraine chronicity are poorly understood. Cytoskeletal flexibility is fundamental to neuronal-plasticity and is dependent on dynamic microtubules. His…
View article: Author response: Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition
Author response: Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Migraine is the sixth most pr…
View article: Delta opioid receptor regulation of calcitonin gene–related peptide dynamics in the trigeminal complex
Delta opioid receptor regulation of calcitonin gene–related peptide dynamics in the trigeminal complex Open
Migraine is highly prevalent and is the sixth leading cause worldwide for years lost to disability. Therapeutic options specifically targeting migraine are limited, and delta opioid receptor (DOP) agonists were recently identified as a pro…
View article: Differential medication overuse risk of novel anti-migraine therapeutics
Differential medication overuse risk of novel anti-migraine therapeutics Open
Medication overuse headache is estimated to affect 2% of the population, and is ranked in the top 20 most disabling disorders due to its high level of disability. Several therapies used in the treatment of acute migraine are thought to be …
View article: Neuronal complexity is attenuated in chronic migraine and restored by HDAC6 inhibition
Neuronal complexity is attenuated in chronic migraine and restored by HDAC6 inhibition Open
Migraine is the third most prevalent disease worldwide but the mechanisms that underlie migraine chronicity are poorly understood. Cytoskeletal flexibility is fundamental to neuronal-plasticity and is dependent on dynamic microtubules. His…
View article: Acid‐sensing ion channel 3 blockade inhibits durovascular and nitric oxide‐mediated trigeminal pain
Acid‐sensing ion channel 3 blockade inhibits durovascular and nitric oxide‐mediated trigeminal pain Open
Background and Purpose There is a major unmet need to develop new therapies for migraine. We have previously demonstrated the therapeutic potential of the acid‐sensing ion channel (ASIC) blockade in migraine, via an ASIC1 mechanism. ASIC3 …
View article: PACAP and Other Neuropeptide Targets Link Chronic Migraine and Opioid-induced Hyperalgesia in Mouse Models*
PACAP and Other Neuropeptide Targets Link Chronic Migraine and Opioid-induced Hyperalgesia in Mouse Models* Open
Chronic use of opioids can produce opioid-induced hyperalgesia (OIH), and when used to treat migraine, these drugs can result in increased pain and headache chronicity. We hypothesized that overlapping mechanisms between OIH and chronic mi…
View article: Gene Network Dysregulation in the Trigeminal Ganglia and Nucleus Accumbens of a Model of Chronic Migraine-Associated Hyperalgesia
Gene Network Dysregulation in the Trigeminal Ganglia and Nucleus Accumbens of a Model of Chronic Migraine-Associated Hyperalgesia Open
The pharmacological agent nitroglycerin (NTG) elicits hyperalgesia and allodynia in mice. This model has been used to study the neurological disorder of trigeminovascular pain or migraine, a debilitating form of hyperalgesia. The present s…
View article: Tolerance to high‐internalizing δ opioid receptor agonist is critically mediated by arrestin 2
Tolerance to high‐internalizing δ opioid receptor agonist is critically mediated by arrestin 2 Open
Background and Purpose Opioid δ receptor agonists are potent antihyperalgesics in chronic pain models, but tolerance develops after prolonged use. Previous evidence indicates that distinct forms of tolerance occur depending on the internal…
View article: Role of signalling molecules in behaviours mediated by the δ opioid receptor agonist SNC80
Role of signalling molecules in behaviours mediated by the δ opioid receptor agonist SNC80 Open
Background and Purpose GPCRs exist in multiple conformations that can engage distinct signalling mechanisms which in turn may lead to diverse behavioural outputs. In rodent models, activation of the δ opioid receptor (δ‐receptor) has been …
View article: Investigating Mechanisms Regulating the In Vivo Actions of Delta Opioid Receptor Ligands
Investigating Mechanisms Regulating the In Vivo Actions of Delta Opioid Receptor Ligands Open
Chronic pain and depression are widespread and debilitating diseases that, for many people, cannot be adequately addressed with current treatment options. Delta opioid receptor (DOR) agonists have been proposed as novel treatments for thes…