Isaac Macwan
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View article: Size-Dependent Interactions of γH2AX and p53 Proteins with Graphene Quantum Dots
Size-Dependent Interactions of γH2AX and p53 Proteins with Graphene Quantum Dots Open
p53 protein is a nuclear phosphoprotein that is a critical tumor suppressor, playing a key role in regulating the cell cycle and initiating apoptosis in response to DNA damage. As a transcription factor, it also activates genes involved in…
View article: Role of Graphene Oxide in Disentangling Amyloid Beta Fibrils
Role of Graphene Oxide in Disentangling Amyloid Beta Fibrils Open
Recently, the accumulation of Amyloid Beta (Aβ) in the brain has been linked to the development of Alzheimer’s disease (AD) through the formation of aggregated plaques and neurofibrillary tangles (NFTs). Although carbon nanoparticles were …
View article: Evaluating the efficacy of uniformly designed square mesh resin 3D printed scaffolds in directing the orientation of electrospun PCL nanofibers
Evaluating the efficacy of uniformly designed square mesh resin 3D printed scaffolds in directing the orientation of electrospun PCL nanofibers Open
Replicating the architecture of extracellular matrices (ECM) is crucial in tissue engineering to support tissues' natural structure and functionality. The ECM's structure plays a significant role in directing cell alignment. Electrospinnin…
View article: Lessons Learned from Fundamentals of Engineering
Lessons Learned from Fundamentals of Engineering Open
interested in developing bioelectronic devices through electrospinning and electropolymerization strategies
View article: Introduction to MATLAB Programming in Fundamentals of Engineering Course
Introduction to MATLAB Programming in Fundamentals of Engineering Course Open
This Evidence-based Practice Paper outlines the benefits of introducing MATLAB to incoming freshmen. MATLAB includes the requisite programming constructs, has an easy to understand Graphical User Interface (GUI), and requires no prior prog…
View article: Embedding Environmental Ethics in Engineering Courses
Embedding Environmental Ethics in Engineering Courses Open
This work focuses on embedding ethics topics in electrical and biomedical engineering courses. A dedicated course titled Engineering Ethics that existed in the curriculum has been replaced in the department recently by embedding ethics top…
View article: Full paper: <Engaging First-Year Engineering Students Through Team-Based Design and Peer Review: A Service-Learning Approach>
Full paper: Open
This complete evidence-based practice paper outlines the benefits of incorporating a challenging team design term project informed by service-learning in a first-year engineering course for students majoring in electrical, biomedical, and …
View article: Term Design Project in Fundamentals of Engineering Course
Term Design Project in Fundamentals of Engineering Course Open
This Complete Evidence-based Practice paper outlines the benefits of incorporating a team-based term design project into a first-year engineering class for students from disciplines including Electrical, Biomedical and Mechanical Engineeri…
View article: Onset of Mismatch Repair by the Human Mismatch Repair Protein, MutSbeta for a Biosensing Device
Onset of Mismatch Repair by the Human Mismatch Repair Protein, MutSbeta for a Biosensing Device Open
Deficiency of MutSbeta protein has been proven to be a cause of Lynch Syndrome, which leads to hereditary colorectal cancer. In the absence of MutSbeta, or the energy source to initiate the conformational change of MutSbeta, the DNA repair…
View article: Computational Investigation of Chirality-Based Separation of Carbon Nanotubes Using Tripeptide Library
Computational Investigation of Chirality-Based Separation of Carbon Nanotubes Using Tripeptide Library Open
Carbon nanotubes (CNT) have fascinating applications in flexible electronics, biosensors, and energy storage devices, and are classified as metallic or semiconducting based on their chirality. Semiconducting CNTs have been teased as a new …
View article: Role of Graphene Oxide in Inhibiting the Interactions between Nucleoside Diphosphate Kinases -B and -C
Role of Graphene Oxide in Inhibiting the Interactions between Nucleoside Diphosphate Kinases -B and -C Open
Nucleoside diphosphate kinase (NDPK) enzyme in the sarcolemma membrane is crucial for the synthesis of cyclic adenosine monophosphate (cAMP) to maintain the calcium ion balance. Typically, NDPK-B residue His118, in the presence of NPDK-C, …
View article: Role of graphene oxide in inhibiting the interactions between nucleoside diphosphate kinases -B and -C
Role of graphene oxide in inhibiting the interactions between nucleoside diphosphate kinases -B and -C Open
During a heart failure, higher amount of nucleoside diphosphate kinase (NDPK) enzyme in the sarcolemma membrane inhibits the synthesis of second messenger cyclic adenosine monophosphate (cAMP), which is required for the regulation of the c…
View article: The Role of Graphene Monolayers in Enhancing the Yield of Bacteriorhodopsin Photostates for Optical Memory Applications
The Role of Graphene Monolayers in Enhancing the Yield of Bacteriorhodopsin Photostates for Optical Memory Applications Open
Bacteriorhodopsin (bR) is a photoactive protein that has gained increasing importance as a tool for optical memory storage due to its remarkable photochemical and thermal stability. The two stable photostates (bR and Q) obtained during the…
View article: Towards Tumor Targeting via Invasive Assay Using Magnetospirillum magneticum
Towards Tumor Targeting via Invasive Assay Using Magnetospirillum magneticum Open
Magnetospirillum magneticum (AMB-1) are a species of magnetotactic bacteria (MTB) that are capable of orienting along the earth’s magnetic field lines through their organelles called magnetosomes. Many studies have shown that certain engin…
View article: Detection of Cardiovascular CRP Protein Biomarker Using a Novel Nanofibrous Substrate
Detection of Cardiovascular CRP Protein Biomarker Using a Novel Nanofibrous Substrate Open
It is known that different diseases have characteristic biomarkers that are secreted very early on, even before the symptoms have developed. Before any kind of therapeutic approach can be used, it is necessary that such biomarkers be detec…
View article: Targeting Tumors Using Invasive Assays Through Magnetosprillium Magneticum
Targeting Tumors Using Invasive Assays Through Magnetosprillium Magneticum Open
Magnetospirillum magneticum (AMB-1) are a species of magnetotactic bacteria that are capable of orienting along the earth’s magnetic field lines through their organelles called magnetosomes. Many studies have shown that certain engineered-…
View article: Molecular Dynamic Simulations of CRISPR and HIV
Molecular Dynamic Simulations of CRISPR and HIV Open
In the United States, there were 37,600 new HIV infections in 2014, with an estimated 1.1 million people living with the disease in 2015, according to the CDC. HIV targets the cell receptor CD4 and chemocine coreceptors CCR5 or CXCR5. Some…
View article: A Bioengineered Memory Storage Device Using Bacteriorhodopsin and Graphene
A Bioengineered Memory Storage Device Using Bacteriorhodopsin and Graphene Open
Bacteriorhodopsin (BR) is a photoactive protein, which has been studied as a memory storage device owing to its photochemical and thermal stability. BR photocycle comprises of two distinct stable binary states, bR (0) and Q (1) based on th…
View article: Understanding the Molecular and Structural Selectivity of Oxidant-induced Nitration and its Reversal in Sarcoplasmic Reticulum Ca2+ -ATPase SERCA2a vs. SERCA1a
Understanding the Molecular and Structural Selectivity of Oxidant-induced Nitration and its Reversal in Sarcoplasmic Reticulum Ca2+ -ATPase SERCA2a vs. SERCA1a Open
The present study uses existing sequence (SERCA1a & SERCA2a) and structure (SERCA1a) information to extrapolate a tertiary structure construct for SERCA2a using computational modeling software. A comparison of SERCA1a and SERCA2a models co…
View article: Size Dependent Graphene Quantum Dot (GQD) Interactions with Protein Biomarkers
Size Dependent Graphene Quantum Dot (GQD) Interactions with Protein Biomarkers Open
Gamma-H2Ax protein is seen at the DNA damage sites and it is also incorporated randomly in to the histones throughout the DNA, which produce other necessary components for the DNA repair. It also contributes to the stable nucleosome format…
View article: Role of Surface Proteins in Magnetotaxis-based Applications
Role of Surface Proteins in Magnetotaxis-based Applications Open
Magnetospirillum magneticum (AMB-1) are a species of magnetotactic bacteria that are capable of orienting along the earth’s magnetic field lines through their organelles called magnetosomes. Many studies have shown that certain engineered-…
View article: 3D Printed Hyaluronic Acid Hydrogels Using Free Form Fabrication Technique for Tissue Engineering
3D Printed Hyaluronic Acid Hydrogels Using Free Form Fabrication Technique for Tissue Engineering Open
Three-Dimensional (3D) printing is a manufacturing method in which objects, such as scaffolds, are made by fusing or depositing various materials in layers. The biomedical applications of 3D printing are numerous and continue to grow expon…
View article: Effect of Microgravity on Nanoparticle-Cellular Interaction
Effect of Microgravity on Nanoparticle-Cellular Interaction Open
A cell contains numerous proteins on its surface and in the cytoplasm that carry out a variety of functions. Maleimide – functionalized Graphene quantum dots (m-GQDs) have the ability to attach or “tag” both cell surface and intracellular …
View article: A Computational Approach for Understanding the Interactions between Graphene Oxide and Nucleoside Diphosphate Kinase with Implications for Heart Failure
A Computational Approach for Understanding the Interactions between Graphene Oxide and Nucleoside Diphosphate Kinase with Implications for Heart Failure Open
During a heart failure, an increased content and activity of nucleoside diphosphate kinase (NDPK) in the sarcolemmal membrane is responsible for suppressing the formation of the second messenger cyclic adenosine monophosphate (cAMP)—a key …
View article: Increasing vaccine production using pulsed ultrasound waves
Increasing vaccine production using pulsed ultrasound waves Open
Vaccination is a safe and effective approach to prevent deadly diseases. To increase vaccine production, we propose that a mechanical stimulation can enhance protein production. In order to prove this hypothesis, Sf9 insect cells were used…