Isaac Tuffour
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View article: Deacetylated Sialic Acid Sensitizes Lung and Colon Cancers to Novel Cucurbitacin-Inspired Estrone Epidermal Growth Factor Receptor (EGFR) Inhibitor Analogs
Deacetylated Sialic Acid Sensitizes Lung and Colon Cancers to Novel Cucurbitacin-Inspired Estrone Epidermal Growth Factor Receptor (EGFR) Inhibitor Analogs Open
Cancers utilize sugar residues such as sialic acids (Sia) to improve their ability to survive. Sia presents a variety of functional group alterations, including O-acetylation on the C6 hydroxylated tail. Previously, sialylation has been re…
View article: Early in vitro evidence indicates that deacetylated sialic acids modulate multi-drug resistance in colon and lung cancers via breast cancer resistance protein
Early in vitro evidence indicates that deacetylated sialic acids modulate multi-drug resistance in colon and lung cancers via breast cancer resistance protein Open
Cancers utilize sugar residues to engage in multidrug resistance. The underlying mechanism of action involving glycans, specifically the glycan sialic acid (Sia) and its various functional group alterations, has not been explored. ATP-bind…
View article: Bioaccumulation of Toxic Metals in Commercially Valuable Fish from the Western Region of Ghana
Bioaccumulation of Toxic Metals in Commercially Valuable Fish from the Western Region of Ghana Open
Fish is an important source of protein, however as human impacts on the environment through industrialization, mining and farming among others is resulting in increased concentration of toxic metals in them.The levels of copper (Cu), arsen…
View article: Heavy metals concentration and pollution index (HPI) in drinking water along the southwest coast of Ghana
Heavy metals concentration and pollution index (HPI) in drinking water along the southwest coast of Ghana Open
The concentration of seven heavy metals in water samples was analyzed along the southwest coast of Ghana in the wet and dry seasons using atomic absorption spectrophotometer. Some physicochemical properties of the water samples were also d…
View article: <i>Schistosoma</i> Egg Antigen Induces Oncogenic Alterations in Human Prostate Cells
<i>Schistosoma</i> Egg Antigen Induces Oncogenic Alterations in Human Prostate Cells Open
Schistosomiasis is a neglected tropical disease that affects 200 million people and accounts for 100,000 deaths annually. In endemic geographical areas, schistosomiasis has been implicated as an etiological agent in the pathogenesis of bla…
View article: In Vivo Modulation of Rat Liver Microsomal Cytochrome P450 Activity by Antimalarial, Anti-HIV, and Antituberculosis Plant Medicines
In Vivo Modulation of Rat Liver Microsomal Cytochrome P450 Activity by Antimalarial, Anti-HIV, and Antituberculosis Plant Medicines Open
Drug interactions are key reasons for adverse drug reactions and attrition from market. Major infectious diseases causing morbidity/mortality in Ghana are malaria, tuberculosis, and HIV/AIDS. In this study, plant medicines commonly used to…
View article: In Vitro Evaluation of Cytotoxic Activities of Marketed Herbal Products in Ghana
In Vitro Evaluation of Cytotoxic Activities of Marketed Herbal Products in Ghana Open
There are numerous herbal products on the Ghanaian market that are purported to cure various ailments, including cancer. However, scientific investigations on efficacy and toxicity of most of these products are not done. The aim of the stu…
View article: Assessment of Heavy Metal Contamination and Distribution in Surface Soils and Plants along the West Coast of Ghana
Assessment of Heavy Metal Contamination and Distribution in Surface Soils and Plants along the West Coast of Ghana Open
Onshore oil drilling activity is ongoing at Jubilee oil fields, Ghana. This activity could lead to heavy metal exposure with consequential adverse effects on public health in nearby coastal communities. Therefore, we assessed heavy metal l…
View article: Constituents of the Roots of Dichapetalum pallidum and Their Anti-Proliferative Activity
Constituents of the Roots of Dichapetalum pallidum and Their Anti-Proliferative Activity Open
As part of our search for bioactive compounds from the Dichapetalaceae, repeated chromatographic purification of the roots of a hitherto unexamined species, Dichapetalum pallidum, led to the isolation of the newly occurring 7-hydroxydichap…
View article: In vitro anti-Leishmania activity of tetracyclic iridoids from Morinda lucida, benth
In vitro anti-Leishmania activity of tetracyclic iridoids from Morinda lucida, benth Open
Leishmaniasis is an infectious disease transmitted by the sand fly. It is caused by over 20 different species of Leishmania and has affected over 14 million people worldwide. One of the main forms of control of leishmaniasis is chemotherap…
View article: CYTOTOXIC EFFECTS OF ALBIZIA ZYGIA (DC) J. F. MACBR, A GHANAIAN MEDICINAL PLANT, AGAINST HUMAN T-LYMPHOBLAST-LIKE LEUKEMIA, PROSTATE AND BREAST CANCER CELL LINES
CYTOTOXIC EFFECTS OF ALBIZIA ZYGIA (DC) J. F. MACBR, A GHANAIAN MEDICINAL PLANT, AGAINST HUMAN T-LYMPHOBLAST-LIKE LEUKEMIA, PROSTATE AND BREAST CANCER CELL LINES Open
Objective: The objectives of this study were to investigate the cytotoxic effects of extracts and fractions of Albizia zygia roots (AZR) on human T-lymphoblast-like leukemia (Jurkat), prostate cancer (LNCap) and breast cancer (MCF-…
View article: Antitrypanosomal Activities and Mechanisms of Action of Novel Tetracyclic Iridoids from Morinda lucida Benth
Antitrypanosomal Activities and Mechanisms of Action of Novel Tetracyclic Iridoids from Morinda lucida Benth Open
Trypanosoma brucei parasites are kinetoplastid protozoa that devastate the health and economic well-being of millions of people in Africa through the disease human African trypanosomiasis (HAT). New chemotherapy has been eagerly awaited du…
View article: Extracts of Codiaeum variegatum (L.) A. Juss is Cytotoxic on Human Leukemic, Breast and Prostate Cancer Cell Lines
Extracts of Codiaeum variegatum (L.) A. Juss is Cytotoxic on Human Leukemic, Breast and Prostate Cancer Cell Lines Open
In Vitro Evaluation of the Anticancer Effect of Methanolic Extract of Alstonia scholaris Leaves on Mammary CarcinomaSurya Surendren P., Jayanthi G, Smitha K.R
View article: In vitro Antioxidant and Anticancer Properties of Hydroethanolic Extracts and Fractions of Ageratum conyzoides
In vitro Antioxidant and Anticancer Properties of Hydroethanolic Extracts and Fractions of Ageratum conyzoides Open
Background: Cancer is still a major public health burden in many countries and despite the research strides made in respect of therapeutic interventions, challenges still abound in cancer treatment.Ageratum conyzoides has increasingly been…
View article: CCDC 1419523: Experimental Crystal Structure Determination
CCDC 1419523: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Anti-proliferative effect of Ficus pumila Linn. on human leukemic cell lines
Anti-proliferative effect of Ficus pumila Linn. on human leukemic cell lines Open
Background: Cancer is one of the many diseases of global concern due to its high mortality rate with drug resistance becoming a major challenge to chemotherapy and this have propelled many cancer patients to seek alternative and complement…