Isaac Yang
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View article: ANGI-22. TREATMENT-INDUCED METASTATIC SECONDARY GLIOSARCOMA OCCURRENCE RATE POST-BEVACIZUMAB TREATMENT IN GLIOBLASTOMA PATIENTS
ANGI-22. TREATMENT-INDUCED METASTATIC SECONDARY GLIOSARCOMA OCCURRENCE RATE POST-BEVACIZUMAB TREATMENT IN GLIOBLASTOMA PATIENTS Open
Bevacizumab is a vascular-endothelial growth factor (VEGF) inhibitor currently approved for treatment of recurrent glioblastomas (GBM). GBM patients treated with bevacizumab, versus standard of care alone, were assessed for rates of SGS de…
View article: Socioeconomic Factors Associate With Access but not Survival in Neurosurgical Brain Tumor Patients
Socioeconomic Factors Associate With Access but not Survival in Neurosurgical Brain Tumor Patients Open
Demographic factors independently associate with healthcare access but not outcomes. Progression through recommended neurosurgical-oncological care is influenced by patient-neurosurgeon relationship and trust in healthcare systems.
View article: Acute vision loss as the presenting symptom of metastatic prostate cancer: A case report and review of the literature
Acute vision loss as the presenting symptom of metastatic prostate cancer: A case report and review of the literature Open
View article: Life expectancy and survival analysis for companion dogs and cats in Seoul, South Korea
Life expectancy and survival analysis for companion dogs and cats in Seoul, South Korea Open
Background Investigating life expectancy and mortality is crucial for the development of evidence-based health strategies for companion animals. However, relevant studies are lacking in South Korea, possibly because of challenges in collec…
View article: Volumetric and diffusion MRI longitudinal patterns in brain metastases after laser interstitial thermal therapy
Volumetric and diffusion MRI longitudinal patterns in brain metastases after laser interstitial thermal therapy Open
Objective To characterize MRI changes of brain metastases (BM) following laser interstitial thermal therapy (LITT), particularly in lesions exhibiting durable response or early progression. Materials and methods Longitudinal scans from pat…
View article: C-FedRAG: A Confidential Federated Retrieval-Augmented Generation System
C-FedRAG: A Confidential Federated Retrieval-Augmented Generation System Open
Organizations seeking to utilize Large Language Models (LLMs) for knowledge querying and analysis often encounter challenges in maintaining an LLM fine-tuned on targeted, up-to-date information that keeps answers relevant and grounded. Ret…
View article: Early-onset stroke-like migraine attacks after radiation therapy syndrome: A case report and review of the literature
Early-onset stroke-like migraine attacks after radiation therapy syndrome: A case report and review of the literature Open
SMART syndrome may present with variations in latency to onset, radiation dose, outcome, and clinical course. The present case of SMART syndrome highlights the variety in clinical presentation of this disease. Further work should be consid…
View article: Ossified spinal epidermoid cyst: A systematic review and case report
Ossified spinal epidermoid cyst: A systematic review and case report Open
View article: Pseudotumour: an uncommon complication of severe haemophilia
Pseudotumour: an uncommon complication of severe haemophilia Open
Pseudotumours are uncommon complications of haemophilia, occurring in 1%-2% of patients with haemophilia.1,2 It is a slowly expanding haematoma as a result of recurrent haemorrhage, surrounded by a fibrous capsule. It can occur in both bon…
View article: Safety and Efficacy of Laser Interstitial Thermal Therapy as Upfront Therapy in Primary Glioblastoma and IDH-Mutant Astrocytoma: A Meta-Analysis
Safety and Efficacy of Laser Interstitial Thermal Therapy as Upfront Therapy in Primary Glioblastoma and IDH-Mutant Astrocytoma: A Meta-Analysis Open
Although primary studies have reported the safety and efficacy of LITT as a primary treatment in glioma, they are limited by sample sizes and institutional variation in stereotactic parameters such as temperature and laser power. The curre…
View article: Understanding the Role of Endothelial Cells in Glioblastoma: Mechanisms and Novel Treatments
Understanding the Role of Endothelial Cells in Glioblastoma: Mechanisms and Novel Treatments Open
Glioblastoma is a highly aggressive neoplasm and the most common primary malignant brain tumor. Endothelial tissue plays a critical role in glioblastoma growth and progression, facilitating angiogenesis, cellular communication, and tumorig…
View article: Primary intraosseous xanthoma of the frontal bone in a child: illustrative case
Primary intraosseous xanthoma of the frontal bone in a child: illustrative case Open
BACKGROUND Skull lesions are a common finding in children, with dermoid cysts and eosinophilic granulomas observed most frequently. However, primary intraosseous xanthomas of the calvaria, which are lytic, expansile lesions that develop wi…
View article: Empowering Federated Learning for Massive Models with NVIDIA FLARE
Empowering Federated Learning for Massive Models with NVIDIA FLARE Open
In the ever-evolving landscape of artificial intelligence (AI) and large language models (LLMs), handling and leveraging data effectively has become a critical challenge. Most state-of-the-art machine learning algorithms are data-centric. …
View article: Intraoperative discovery of a radiographically occult subependymoma obstructing the obex in a patient with a Chiari malformation – A rare case
Intraoperative discovery of a radiographically occult subependymoma obstructing the obex in a patient with a Chiari malformation – A rare case Open
Background: Chiari (type I) malformations are typically congenital. Occasionally, however, tonsillar herniation can arise secondary to cerebrospinal fluid leakage, posterior fossa or intraventricular mass lesions, or other etiologies. We p…
View article: NCMP-07. HEADACHE PRESENTATION AND MANAGEMENT IN VON HIPPEL-LINDAU (VHL)-ASSOCIATED HEMANGIOBLASTOMAS
NCMP-07. HEADACHE PRESENTATION AND MANAGEMENT IN VON HIPPEL-LINDAU (VHL)-ASSOCIATED HEMANGIOBLASTOMAS Open
BACKGROUND Hemangioblastomas are the most common brain tumors among patients with Von Hippel-Lindau (VHL) disease. Common characteristics of these benign tumors, such as tumor growth, peritumoral edema, and cystic expansion, may lead to ne…
View article: TMIC-29. BEVACIZUMAB IS ASSOCIATED WITH INCREASED RATE OF RECURRENCE IN GLIOBLASTOMA
TMIC-29. BEVACIZUMAB IS ASSOCIATED WITH INCREASED RATE OF RECURRENCE IN GLIOBLASTOMA Open
BACKGROUND The primary cause of Glioblastoma’s (GBM) dismal outcomes is the high rate of tumor recurrence, which is closely related to its resistance to standard therapies. Bevacizumab has increasingly been used in the treatment of recurre…
View article: SURG-45. THE EFFECT OF STAPEDECTOMY IN POSTOPERATIVE OUTCOME OF SUPERIOR SEMICIRCULAR CANAL DEHISCENCE: A CASE SERIES OF 349 REPAIRS
SURG-45. THE EFFECT OF STAPEDECTOMY IN POSTOPERATIVE OUTCOME OF SUPERIOR SEMICIRCULAR CANAL DEHISCENCE: A CASE SERIES OF 349 REPAIRS Open
INTRODUCTION Superior Semicircular Canal Dehiscence (SSCD) is a pathology of the otic capsule, in which, a “third mobile window” is formed on the osseous labyrinth surrounding the superior semicircular canal. Otosclerosis, another otic cap…
View article: ANGI-11. MOLECULAR MECHANISM OF TARGETING EPITHELIAL MEMBRANE PROTEIN-2 IN MALIGNANT MENINGIOMAS
ANGI-11. MOLECULAR MECHANISM OF TARGETING EPITHELIAL MEMBRANE PROTEIN-2 IN MALIGNANT MENINGIOMAS Open
BACKGROUND Meningiomas comprise approximately one-third of all primary central nervous system neoplasms. While many meningiomas remain benign, as many as 35% of meningiomas are graded as atypical or anaplastic/malignant with a 5-y survival…
View article: RADT-23. STEREOTACTIC RADIOSURGERY FOR CYSTIC VESTIBULAR SCHWANNOMA - A SYSTEMATIC REVIEW
RADT-23. STEREOTACTIC RADIOSURGERY FOR CYSTIC VESTIBULAR SCHWANNOMA - A SYSTEMATIC REVIEW Open
BACKGROUND Cystic vestibular schwannoma, also historically known as cystic acoustic neuroma, is a benign intracranial tumor that can form between the pons and the cerebellum in an area known as the cerebellopontine angle. These brain tumor…
View article: Cervicomedullary junction mature teratoma with pulmonary differentiation and diastematomyelia in an adult – A rare case
Cervicomedullary junction mature teratoma with pulmonary differentiation and diastematomyelia in an adult – A rare case Open
Background: Intradural extramedullary teratomas in the cervical or cervicomedullary region are rare in adults. Case Description: We report a symptomatic, mature teratoma at the cervicomedullary junction in a 52-year-old Hispanic female who…
View article: Small pretreatment lesion size and high sphericity as favorable prognostic factors after laser interstitial thermal therapy in brain metastases
Small pretreatment lesion size and high sphericity as favorable prognostic factors after laser interstitial thermal therapy in brain metastases Open
OBJECTIVE The objective of this study was to identify baseline clinical and radiological characteristics of brain metastases (BMs) associated with a higher probability of lesion-specific progression-free survival (PFS-L) after laser inters…
View article: NEIM-12 PRE- AND POST-TREATMENT RADIOLOGIC FEATURES AND VOLUMETRIC CHANGES LINKED TO TREATMENT RESPONSE OF BRAIN METASTASES AFTER LASER INTERSTITIAL THERMAL THERAPY (LITT)
NEIM-12 PRE- AND POST-TREATMENT RADIOLOGIC FEATURES AND VOLUMETRIC CHANGES LINKED TO TREATMENT RESPONSE OF BRAIN METASTASES AFTER LASER INTERSTITIAL THERMAL THERAPY (LITT) Open
OBJECTIVE To identify pre-treatment imaging features of brain metastases (BM) associated with lesion-specific progression free survival (PFS-L) after laser interstitial thermal therapy (LITT) and to report longitudinal volumetric changes f…
View article: Multi-nuclear sodium, diffusion, and perfusion MRI in human gliomas
Multi-nuclear sodium, diffusion, and perfusion MRI in human gliomas Open
View article: Exploring the Past, Present, and Future of Anti-Angiogenic Therapy in Glioblastoma
Exploring the Past, Present, and Future of Anti-Angiogenic Therapy in Glioblastoma Open
Glioblastoma, a WHO grade IV astrocytoma, constitutes approximately half of malignant tumors of the central nervous system. Despite technological advancements and aggressive multimodal treatment, prognosis remains dismal. The highly vascul…
View article: A Case Series of DuraMatrix-Onlay<sup>®</sup> Plus in Cranial Surgery Is Associated With a Low Complication Profile
A Case Series of DuraMatrix-Onlay<sup>®</sup> Plus in Cranial Surgery Is Associated With a Low Complication Profile Open
DuraMatrix-Onlay® Plus is associated with a low rate of postoperative CSF leakage and an acceptable complication profile. This result supports the use of collagen matrices for dural closure in general neurosurgical procedures.
View article: Endoscopic endonasal approach for resection of a recurrent spheno-orbital meningioma resulting in complete resolution of visual symptoms: A case report and review of literature
Endoscopic endonasal approach for resection of a recurrent spheno-orbital meningioma resulting in complete resolution of visual symptoms: A case report and review of literature Open
Purpose Spheno-orbital meningiomas are rare tumors, accounting for up to 9% of all intracranial meningiomas. Patients commonly present with proptosis, and visual deficits. These slow growing tumors are hard to resect due to extension into …
View article: Epithelial membrane protein 2 (EMP2): A systematic review of its implications in pathogenesis
Epithelial membrane protein 2 (EMP2): A systematic review of its implications in pathogenesis Open
Overall, the evidence suggests the mechanisms of action of EMP2 are context dependent. Promising results have been produced by utilizing EMP2 as a biomarker and therapeutic target. More studies are warranted to better understand the mechan…
View article: MONAI: An open-source framework for deep learning in healthcare
MONAI: An open-source framework for deep learning in healthcare Open
Artificial Intelligence (AI) is having a tremendous impact across most areas of science. Applications of AI in healthcare have the potential to improve our ability to detect, diagnose, prognose, and intervene on human disease. For AI model…
View article: ANGI-01. METASTATIC ESTHESIONEUROBLASTOMA RECURRENCE AFTER 19 YEARS OF REMISSION: A SYSTEMATIC REVIEW WITH CASE ILLUSTRATION
ANGI-01. METASTATIC ESTHESIONEUROBLASTOMA RECURRENCE AFTER 19 YEARS OF REMISSION: A SYSTEMATIC REVIEW WITH CASE ILLUSTRATION Open
INTRODUCTION Esthesioneuroblastoma (ENB) is a rare malignant neoplasm of the olfactory epithelium with an estimated incidence of 0.4/million. It can directly extend along the cribriform plate in order to metastasize to the central nervous …
View article: RADT-14. COMBINATION RE-RADIATION AND BEVACIZUMAB THERAPY FOR RECURRENT GLIOBLASTOMA: CLINICAL OUTCOMES OF 337 PATIENTS
RADT-14. COMBINATION RE-RADIATION AND BEVACIZUMAB THERAPY FOR RECURRENT GLIOBLASTOMA: CLINICAL OUTCOMES OF 337 PATIENTS Open
BACKGROUND High-grade gliomas (HGGs) comprise the most common primary adult brain cancers and universally recur. Glioblastoma (GBM) compromise 60% of HGGs with an extremely poor prognosis and are considered incurable despite many treatment…