Isabel Beerman
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View article: Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis
Integrated omics reveals disease-associated radial glia-like cells with epigenetically dysregulated interferon response in multiple sclerosis Open
Progressive multiple sclerosis (PMS) involves a persistent, maladaptive inflammatory process with numerous cellular drivers. We generated induced neural stem cells (iNSCs) from patient fibroblasts through a direct reprogramming protocol th…
View article: Nicotinamide riboside treatment enhances stress sensitivity and modulates hematological dynamics in aged mice
Nicotinamide riboside treatment enhances stress sensitivity and modulates hematological dynamics in aged mice Open
Nicotinamide riboside (NR) is a precursor to NAD + , a vital molecule for cellular energy metabolism whose levels decline with age. Aging is associated with loss of cognitive and immune function, alterations in hematological parameters, an…
View article: Biomarkers of Aging– <scp>NIA</scp> Joint Symposium 2024: New Insights Into Aging Biomarkers
Biomarkers of Aging– <span>NIA</span> Joint Symposium 2024: New Insights Into Aging Biomarkers Open
The second Biomarkers of Aging Symposium, jointly hosted by the National Institute on Aging (NIA) Intramural Research Program and the Biomarkers of Aging Consortium (BAC) on September 12, 2024, in Baltimore, MD, convened leading researcher…
View article: AGE-ASSOCIATED ALTERATIONS IN HEMATOPOIESIS
AGE-ASSOCIATED ALTERATIONS IN HEMATOPOIESIS Open
View article: Semaphorin 4A maintains functional diversity of the hematopoietic stem cell pool
Semaphorin 4A maintains functional diversity of the hematopoietic stem cell pool Open
SUMMARY Somatic stem cell pools are comprised of diverse, highly specialized subsets whose individual contribution is critical for the overall regenerative function. In the bone marrow, myeloid-biased HSC (myHSC) are indispensable for repl…
View article: DNA methylation drives hematopoietic stem cell aging phenotypes after proliferative stress
DNA methylation drives hematopoietic stem cell aging phenotypes after proliferative stress Open
Aging of hematopoietic stem cells (HSCs) is implicated in various aging phenotypes, including immune dysfunction, anemia, and malignancies. The role of HSC proliferation in driving these aging phenotypes, particularly under stress conditio…
View article: Cellular stress and epigenetic regulation in adult stem cells
Cellular stress and epigenetic regulation in adult stem cells Open
Stem cells are a unique class of cells that possess the ability to differentiate and self-renew, enabling them to repair and replenish tissues. To protect and maintain the potential of stem cells, the cells and the environment surrounding …
View article: Identification of senescent cell subpopulations by <scp>CITE</scp>‐seq analysis
Identification of senescent cell subpopulations by <span>CITE</span>‐seq analysis Open
Cellular senescence, a state of persistent growth arrest, is closely associated with aging and age‐related diseases. Deciphering the heterogeneity within senescent cell populations and identifying therapeutic targets are paramount for miti…
View article: Three-dimensional chromatin reorganization regulates B cell development during ageing
Three-dimensional chromatin reorganization regulates B cell development during ageing Open
The contribution of three-dimensional genome organization to physiological ageing is not well known. Here we show that large-scale chromatin reorganization distinguishes young and old bone marrow progenitor (pro-) B cells. These changes re…
View article: Integrative single-cell analysis of neural stem/progenitor cells reveals epigenetically dysregulated interferon response in progressive multiple sclerosis
Integrative single-cell analysis of neural stem/progenitor cells reveals epigenetically dysregulated interferon response in progressive multiple sclerosis Open
SUMMARY Progressive multiple sclerosis (PMS) is characterized by a primary smouldering pathological disease process associated with a superimposed inflammatory activity. Cellular and molecular processes sustaining the pathobiology of PMS r…
View article: Short-term periodic restricted feeding elicits metabolome-microbiome signatures with sex dimorphic persistence in primate intervention
Short-term periodic restricted feeding elicits metabolome-microbiome signatures with sex dimorphic persistence in primate intervention Open
Dietary restriction has shown benefits in physiological, metabolic, and molecular signatures associated with aging but is a difficult lifestyle to maintain for most individuals. In mice, a less restrictive diet that allows for cyclical per…
View article: Tristetraprolin overexpression drives hematopoietic changes in young and middle-aged mice generating dominant mitigating effects on induced inflammation in murine models
Tristetraprolin overexpression drives hematopoietic changes in young and middle-aged mice generating dominant mitigating effects on induced inflammation in murine models Open
Tristetraprolin (TTP), encoded by Zfp36 in mice, is one of the best-characterized tandem zinc-finger mRNA binding proteins involved in mRNA deadenylation and decay. TTPΔARE mice lack an AU-rich motif in the 3′-untranslated regions of TTP m…
View article: Lethal eosinophilic crystalline pneumonia in mice expressing a stabilized <i>Csf2</i> <scp>mRNA</scp>
Lethal eosinophilic crystalline pneumonia in mice expressing a stabilized <i>Csf2</i> <span>mRNA</span> Open
Granulocyte–macrophage colony‐stimulating factor (GM‐CSF) is a cytokine that stimulates the proliferation and differentiation of granulocyte and macrophage precursors. The mouse gene‐encoding GM‐CSF, Csf2 , is regulated at both transcripti…
View article: Frontiers in aging special issue: DNA repair and interventions in aging perspective on “loss of epigenetic information as a cause of mammalian aging”
Frontiers in aging special issue: DNA repair and interventions in aging perspective on “loss of epigenetic information as a cause of mammalian aging” Open
The recently published article in Cell by the Sinclair lab and collaborators entitled “Loss of Epigenetic Information as a Cause of Mammalian Aging” [1] implicates heritable changes in gene expression as the basis for aging, a postulate co…
View article: Cancer promotes immune escape via transdifferentiating B cells into macrophage-like cells
Cancer promotes immune escape via transdifferentiating B cells into macrophage-like cells Open
Previously we reported that breast cancer uses the generation of regulatory TGFb+ B cells to facilitate its metastasis via inducing FoxP3+Tregs and educating MDSCs 1,2. To do this, the cancer secretes TSLP to cause premature emigration of …
View article: Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo
Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo Open
Short telomeres are a defining feature of telomere biology disorders (TBDs), including dyskeratosis congenita (DC), for which there is no effective general cure. Patients with TBDs often experience bone marrow failure. NAD, an essential me…
View article: Male rat leukocyte population dynamics predict a window for intervention in aging
Male rat leukocyte population dynamics predict a window for intervention in aging Open
Many age-associated changes in the human hematopoietic system have been reproduced in murine models; however, such changes have not been as robustly explored in rats despite the fact these larger rodents are more physiologically similar to…
View article: Author response: Male rat leukocyte population dynamics predict a window for intervention in aging
Author response: Male rat leukocyte population dynamics predict a window for intervention in aging Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Methods Data availability References Decision letter Author response Article and author information Metrics Abstract Many age-associated cha…
View article: Proteomes of primary skin fibroblasts from healthy individuals reveal altered cell responses across the life span
Proteomes of primary skin fibroblasts from healthy individuals reveal altered cell responses across the life span Open
Changes in the proteome of different human tissues with advancing age are poorly characterized. Here, we studied the proteins present in primary skin fibroblasts collected from 82 healthy individuals across a wide age spectrum (22–89 years…
View article: Short-term senolytic treatment: a paradigm to promote fracture repair during aging
Short-term senolytic treatment: a paradigm to promote fracture repair during aging Open
Increased age is blamed for a wide range of bone physiological changes, and although the underlying mechanisms affecting the decreased capacity for fracture healing are not fully understood, they are clearly linked to changes at the cellul…
View article: Rat Leukocyte Population Dynamics Predicts a Window for Intervention in Aging
Rat Leukocyte Population Dynamics Predicts a Window for Intervention in Aging Open
Age-associated changes in human hematopoiesis have been mostly recapitulated in mouse models; but not much has been explored in rats, a physiologically closer model to humans. To establish whether rat hematopoiesis closely mirrors humans’,…
View article: Potential of Stem Cell-Based Therapy to Restore Function in Aging Systems: Are We There Yet?
Potential of Stem Cell-Based Therapy to Restore Function in Aging Systems: Are We There Yet? Open
While there is extensive interest in geroscience approaches to health and disease, few basic science discoveries have made their way into clinical trials. Herein, we comment on cell-based therapies, in which supplementing robust stem cell …
View article: Effects of Caloric Restriction on the Epigenetic Landscape of Hematopoietic Stem Cells
Effects of Caloric Restriction on the Epigenetic Landscape of Hematopoietic Stem Cells Open
During aging, alterations of hematopoietic stem cells are associated with functional decline of the blood system. Caloric restriction (CR) interventions have been reported to improve adult stem cells in other tissue types during aging so w…
View article: Utility of plasma cell-free DNA for <i>de novo</i> detection and quantification of clonal hematopoiesis
Utility of plasma cell-free DNA for <i>de novo</i> detection and quantification of clonal hematopoiesis Open
Although cell-free DNA (cfDNA) tests have emerged as a potential non-invasive alternative to bone marrow biopsies for monitoring clonal hematopoiesis in hematologic diseases, whether commercial cfDNA assays can be implemented for the detec…
View article: NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm−/− and old mice HSCs
NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm−/− and old mice HSCs Open
NAD + supplementation has significant benefits in compromised settings, acting largely through improved mitochondrial function and DNA repair. Elevating NAD + to physiological levels has been shown to improve the function of some adult ste…
View article: Cancer coopts differentiation of B-cell precursors into macrophages
Cancer coopts differentiation of B-cell precursors into macrophages Open
We recently reported that some cancers induce accumulation of bone marrow (BM) B-cell precursors in the spleen to convert them into metastasis-promoting, immunosuppressive B cells. Here, using various murine tumor models and samples from h…