Isabel Beets
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View article: A gene expression atlas of a juvenile nervous system
A gene expression atlas of a juvenile nervous system Open
Although the fundamental architecture of metazoan nervous systems is typically established in the embryo, substantial numbers of neurons are added during post-natal development while existing neurons expand in size, refine connectivity, an…
View article: Ce-NeRV3D - a C. elegans Neuron RNA-seq Visualization tool in 3D
Ce-NeRV3D - a C. elegans Neuron RNA-seq Visualization tool in 3D Open
Caenorhabditis elegans provides a tractable model for neural circuit studies, with complete connectomes and single-cell transcriptomic atlases available. Here, we present Ce-NeRV3D (C. elegans Neuron RNA-seq Visualizat…
View article: Learning From Smart Worms
Learning From Smart Worms Open
The human brain is the most complicated system in biology, and there is still much to be discovered about how it works. How are we able to learn new things and remember what we learned? How come some children have learning difficulties, an…
View article: Biodiversity2Drugs—Renaissance of exploring nature‐derived peptides for GPCR ligand discovery
Biodiversity2Drugs—Renaissance of exploring nature‐derived peptides for GPCR ligand discovery Open
View article: Divergence in neuronal signaling pathways despite conserved neuronal identity among Caenorhabditis species
Divergence in neuronal signaling pathways despite conserved neuronal identity among Caenorhabditis species Open
One avenue to better understand brain evolution is to map molecular patterns of evolutionary changes in neuronal cell types across entire nervous systems of distantly related species. Generating whole-animal single-cell transcriptomes of t…
View article: The neuropeptide FLP-11 induces and self-inhibits sleep through the receptor DMSR-1 in Caenorhabditis elegans
The neuropeptide FLP-11 induces and self-inhibits sleep through the receptor DMSR-1 in Caenorhabditis elegans Open
View article: Mapping and decoding neuropeptide signaling networks in nervous system function
Mapping and decoding neuropeptide signaling networks in nervous system function Open
View article: DeorphaNN: Virtual screening of GPCR peptide agonists using AlphaFold-predicted active-state complexes and deep learning embeddings
DeorphaNN: Virtual screening of GPCR peptide agonists using AlphaFold-predicted active-state complexes and deep learning embeddings Open
Peptide-activated G protein-coupled receptors (GPCRs) regulate critical physiological processes such as metabolism, neural signalling, and endocrine function through their interaction with neuropeptides and peptide hormones. Despite their …
View article: C. elegans wired and wireless connectome: insights into principles of nervous system structure and function
C. elegans wired and wireless connectome: insights into principles of nervous system structure and function Open
View article: Exploitation of phylum-spanning omics resources reveals complexity in the nematode FLP signalling system and provides insights into flp-gene evolution
Exploitation of phylum-spanning omics resources reveals complexity in the nematode FLP signalling system and provides insights into flp-gene evolution Open
Background Parasitic nematodes significantly undermine global human and animal health and productivity. Parasite control is reliant on anthelmintic administration however over-use of a limited number of drugs has resulted in escalating par…
View article: Two K2P Channels, TWK-46 and TWK-26 do not affect C. elegans Egg-Laying Behavior
Two K2P Channels, TWK-46 and TWK-26 do not affect C. elegans Egg-Laying Behavior Open
Two-pore domain potassium channels, also known as K2P channels, play vital roles in maintaining the resting membrane potential in excitable cells, affecting a variety of physiological processes across species. The Caenorhabditis elegans…
View article: Molecular patterns of evolutionary changes throughout the whole nervous system of multiple nematode species
Molecular patterns of evolutionary changes throughout the whole nervous system of multiple nematode species Open
One avenue to better understand brain evolution is to map molecular patterns of evolutionary changes in neuronal cell types across entire nervous systems of distantly related species. Generating whole-animal single-cell transcriptomes of t…
View article: Cell non-autonomous signaling through the conserved C. elegans glycoprotein hormone receptor FSHR-1 regulates cholinergic neurotransmission
Cell non-autonomous signaling through the conserved C. elegans glycoprotein hormone receptor FSHR-1 regulates cholinergic neurotransmission Open
Modulation of neurotransmission is key for organismal responses to varying physiological contexts such as during infection, injury, or other stresses, as well as in learning and memory and for sensory adaptation. Roles for cell autonomous …
View article: Hierarchical regulation of functionally antagonistic neuropeptides expressed in a single neuron pair
Hierarchical regulation of functionally antagonistic neuropeptides expressed in a single neuron pair Open
View article: Global analysis of neuropeptide receptor conservation across phylum Nematoda
Global analysis of neuropeptide receptor conservation across phylum Nematoda Open
The repertoire of C. elegans peptide GPCR orthologs varies across phylogenetic clades and several peptide GPCRs show broad conservation in the phylum Nematoda. Our work functionally characterizes the conserved receptors NPR-9 and NPR-16 as…
View article: Neuropeptide signaling network of <i>Caenorhabditis elegans</i>: from structure to behavior
Neuropeptide signaling network of <i>Caenorhabditis elegans</i>: from structure to behavior Open
Neuropeptides are abundant signaling molecules that control neuronal activity and behavior in all animals. Owing in part to its well-defined and compact nervous system, Caenorhabditis elegans has been one of the primary model organisms use…
View article: Exploitation of phylum-spanning omics resources reveals complexity in the nematode FLP signalling system and provides insights into<i>flp</i>-gene evolution
Exploitation of phylum-spanning omics resources reveals complexity in the nematode FLP signalling system and provides insights into<i>flp</i>-gene evolution Open
Background Parasitic nematodes significantly undermine global human and animal health and productivity. Parasite control is reliant on anthelmintic administration however over-use of a limited number of drugs has resulted in escalating par…
View article: Molecular circadian rhythms are robust in marine annelids lacking rhythmic behavior
Molecular circadian rhythms are robust in marine annelids lacking rhythmic behavior Open
The circadian clock controls behavior and metabolism in various organisms. However, the exact timing and strength of rhythmic phenotypes can vary significantly between individuals of the same species. This is highly relevant for rhythmical…
View article: Antagonism between neuropeptides and monoamines in a distributed circuit for pathogen avoidance
Antagonism between neuropeptides and monoamines in a distributed circuit for pathogen avoidance Open
View article: Cell non-autonomous signaling through the conserved <i>C. elegans</i> glycopeptide hormone receptor FSHR-1 regulates cholinergic neurotransmission
Cell non-autonomous signaling through the conserved <i>C. elegans</i> glycopeptide hormone receptor FSHR-1 regulates cholinergic neurotransmission Open
Modulation of neurotransmission is key for organismal responses to varying physiological contexts such as during infection, injury, or other stresses, as well as in learning and memory and for sensory adaptation. Roles for cell autonomous …
View article: Evolutionary conserved peptide and glycoprotein hormone-like neuroendocrine systems in C. elegans
Evolutionary conserved peptide and glycoprotein hormone-like neuroendocrine systems in C. elegans Open
View article: Hierarchical regulation of functionally antagonistic neuropeptides expressed in a single neuron pair
Hierarchical regulation of functionally antagonistic neuropeptides expressed in a single neuron pair Open
Summary Neuronal communication involves small-molecule transmitters, gap junctions, and neuropeptides. While neurons often express multiple neuropeptides, our understanding of the coordination of their action and their mutual interactions …
View article: The neuropeptidergic connectome of C. elegans
The neuropeptidergic connectome of C. elegans Open
Efforts are ongoing to map synaptic wiring diagrams, or connectomes, to understand the neural basis of brain function. However, chemical synapses represent only one type of functionally important neuronal connection; in particular, extrasy…
View article: Comparing engineered nuclear-localized reporter cassettes
Comparing engineered nuclear-localized reporter cassettes Open
Recent single-cell transcriptome analysis has revealed a tremendous breadth and specificity of neuropeptide-encoding gene expression in the nervous system of C. elegans. To analyze the dynamics of neuropeptide gene expression, as we…
View article: System-wide mapping of peptide-GPCR interactions in C. elegans
System-wide mapping of peptide-GPCR interactions in C. elegans Open
View article: Ancestral glycoprotein hormone-receptor pathway controls growth in C. elegans
Ancestral glycoprotein hormone-receptor pathway controls growth in C. elegans Open
In vertebrates, thyrostimulin is a highly conserved glycoprotein hormone that, besides thyroid stimulating hormone (TSH), is a potent ligand of the TSH receptor. Thyrostimulin is considered the most ancestral glycoprotein hormone and ortho…
View article: Multisite regulation integrates multimodal context in sensory circuits to control persistent behavioral states in C. elegans
Multisite regulation integrates multimodal context in sensory circuits to control persistent behavioral states in C. elegans Open
Maintaining or shifting between behavioral states according to context is essential for animals to implement fitness-promoting strategies. How the integration of internal state, past experience and sensory inputs orchestrates persistent mu…
View article: An ancient thyrostimulin-like neuroendocrine pathway regulates growth in<i>Caenorhabditis elegans</i>
An ancient thyrostimulin-like neuroendocrine pathway regulates growth in<i>Caenorhabditis elegans</i> Open
In vertebrates, thyrostimulin is a highly conserved glycoprotein hormone that, besides thyroid stimulating hormone (TSH), is a potent ligand of the TSH receptor. Thyrostimulin is considered the most ancestral glycoprotein hormone and ortho…
View article: Mass Spectrometry–Driven Discovery of Neuropeptides Mediating Nictation Behavior of Nematodes
Mass Spectrometry–Driven Discovery of Neuropeptides Mediating Nictation Behavior of Nematodes Open
Neuropeptides regulate animal physiology and behavior, making them widely studied targets of functional genetics research. While the field often relies on differential -omics approaches to build hypotheses, no such method exists for neurop…
View article: System-wide mapping of neuropeptide-GPCR interactions in<i>C. elegans</i>
System-wide mapping of neuropeptide-GPCR interactions in<i>C. elegans</i> Open
Summary Neuropeptides are ancient, widespread signaling molecules that underpin almost all brain functions. They constitute a broad ligand-receptor network, mainly by binding to G protein-coupled receptors (GPCRs). However, the organizatio…