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View article: Detectable SARS-CoV-2 specific immune responses in recovered unvaccinated individuals 250 days post wild type infection
Detectable SARS-CoV-2 specific immune responses in recovered unvaccinated individuals 250 days post wild type infection Open
Memory T cells play an important role in mediating long-lasting adaptive immune responses to viral infections, such as SARS-CoV-2. In the context of the latter, much of our current knowledge stems from studies in vaccinated individuals or …
View article: Differential DNA methylation 7 months after SARS-CoV-2 infection
Differential DNA methylation 7 months after SARS-CoV-2 infection Open
View article: Persistent immune abnormalities discriminate post-COVID syndrome from convalescence
Persistent immune abnormalities discriminate post-COVID syndrome from convalescence Open
Background Innate lymphoid cells (ILCs) are key organizers of tissue immune responses and regulate tissue development, repair, and pathology. Persistent clinical sequelae beyond 12 weeks following acute COVID-19 disease, named post-COVID s…
View article: Studying temporal titre evolution of commercial SARS-CoV-2 assays reveals significant shortcomings of using BAU standardization for comparison
Studying temporal titre evolution of commercial SARS-CoV-2 assays reveals significant shortcomings of using BAU standardization for comparison Open
Background Measuring specific anti-SARS-CoV-2 antibodies has become one of the main epidemiological tools to survey the ongoing SARS-CoV-2 pandemic, but also vaccination response. The WHO made available a set of well-characterized samples …
View article: The representative COVID-19 cohort Munich (KoCo19): from the beginning of the pandemic to the Delta virus variant
The representative COVID-19 cohort Munich (KoCo19): from the beginning of the pandemic to the Delta virus variant Open
View article: Persistent immune abnormalities discriminate post-COVID syndrome from convalescence
Persistent immune abnormalities discriminate post-COVID syndrome from convalescence Open
Innate lymphoid cells (ILCs) are key organizers of tissue immune responses and regulate tissue development, repair, and pathology. Persistent clinical sequelae beyond 12 weeks following acute COVID-19 disease, named post-COVID syndrome (PC…
View article: Head-to-head evaluation of seven different seroassays including direct viral neutralisation in a representative cohort for SARS-CoV-2
Head-to-head evaluation of seven different seroassays including direct viral neutralisation in a representative cohort for SARS-CoV-2 Open
A number of seroassays are available for SARS-CoV-2 testing; yet, head-to-head evaluations of different testing principles are limited, especially using raw values rather than categorical data. In addition, identifying correlates of protec…
View article: From first to second wave: follow-up of the prospective COVID-19 cohort (KoCo19) in Munich (Germany)
From first to second wave: follow-up of the prospective COVID-19 cohort (KoCo19) in Munich (Germany) Open
View article: Spatially resolved qualified sewage spot sampling to track SARS-CoV-2 dynamics in Munich - One year of experience
Spatially resolved qualified sewage spot sampling to track SARS-CoV-2 dynamics in Munich - One year of experience Open
View article: In Search of the SARS-CoV-2 Protection Correlate: Head-to-Head Comparison of Two Quantitative S1 Assays in Pre-characterized Oligo-/Asymptomatic Patients
In Search of the SARS-CoV-2 Protection Correlate: Head-to-Head Comparison of Two Quantitative S1 Assays in Pre-characterized Oligo-/Asymptomatic Patients Open
Our findings suggest both quantitative anti-S1 assays (EI-S1-IgG-quant and Ro-RBD-Ig-quant) may replace direct neutralization assays in quantitative measurement of immune protection against SARS-CoV-2 in certain circumstances. However, alt…
View article: Broad T Cell Targeting of Structural Proteins After SARS-CoV-2 Infection: High Throughput Assessment of T Cell Reactivity Using an Automated Interferon Gamma Release Assay
Broad T Cell Targeting of Structural Proteins After SARS-CoV-2 Infection: High Throughput Assessment of T Cell Reactivity Using an Automated Interferon Gamma Release Assay Open
Background Adaptive immune responses to structural proteins of the virion play a crucial role in protection against coronavirus disease 2019 (COVID-19). We therefore studied T cell responses against multiple SARS-CoV-2 structural proteins …
View article: From first to second wave: follow-up of the prospective Covid-19 cohort (KoCo19) in Munich (Germany)
From first to second wave: follow-up of the prospective Covid-19 cohort (KoCo19) in Munich (Germany) Open
Background In the 2 nd year of the Covid-19 pandemic, knowledge about the dynamics of the infection in the general population is still limited. Such information is essential for health planners, as many of those infected show no or only mi…
View article: Prevalence and Risk Factors of Infection in the Representative COVID-19 Cohort Munich
Prevalence and Risk Factors of Infection in the Representative COVID-19 Cohort Munich Open
Given the large number of mild or asymptomatic SARS-CoV-2 cases, only population-based studies can provide reliable estimates of the magnitude of the pandemic. We therefore aimed to assess the sero-prevalence of SARS-CoV-2 in the Munich ge…
View article: A Serology Strategy for Epidemiological Studies Based on the Comparison of the Performance of Seven Different Test Systems - The Representative COVID-19 Cohort Munich
A Serology Strategy for Epidemiological Studies Based on the Comparison of the Performance of Seven Different Test Systems - The Representative COVID-19 Cohort Munich Open
Background Serosurveys are essential to understand SARS-CoV-2 exposure and enable population-level surveillance, but currently available tests need further in-depth evaluation. We aimed to identify testing-strategies by comparing seven ser…
View article: Prevalence and Risk Factors of Infection in the Representative COVID-19 Cohort Munich
Prevalence and Risk Factors of Infection in the Representative COVID-19 Cohort Munich Open