Isabel Cuella Martin
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View article: Drug resistance of Mycobacterium tuberculosis to linezolid and delamanid: a case report from Bukavu, Democratic Republic of Congo
Drug resistance of Mycobacterium tuberculosis to linezolid and delamanid: a case report from Bukavu, Democratic Republic of Congo Open
The emergence of resistance is of great concern in the control of TB, especially to the new and repurposed drugs needed for the treatment of rifampicin resistance. We report a patient from South Kivu in the Eastern Democratic Republic of t…
View article: Paucibacillary Tuberculosis Drives the Low Positive Predictive Value of Xpert MTB/RIF Ultra for Rifampicin Resistance Detection in Low-Prevalence Settings
Paucibacillary Tuberculosis Drives the Low Positive Predictive Value of Xpert MTB/RIF Ultra for Rifampicin Resistance Detection in Low-Prevalence Settings Open
Background Xpert MTB/RIF Ultra (Ultra) aimed to improve the specificity in identifying rifampicin-resistant tuberculosis (RR-TB), compared to Xpert MTB/RIF. Methods In a nationwide study in Rwanda, patients diagnosed with RR-TB by Ultra be…
View article: Direct thin-layer agar for bedaquiline-susceptibility testing of <i>Mycobacterium tuberculosis</i> at BSL2 level yields high accuracy in 15 days from sputum processing
Direct thin-layer agar for bedaquiline-susceptibility testing of <i>Mycobacterium tuberculosis</i> at BSL2 level yields high accuracy in 15 days from sputum processing Open
This study evaluated thin-layer agar (TLA) as a faster alternative for both indirect minimum inhibitory concentration (MIC) determination of bedaquiline (BDQ) from culture isolates and direct drug-susceptibility testing (DST) from sputum s…
View article: Direct thin-layer agar for bedaquiline-susceptibility testing of<i>Mycobacterium tuberculosis</i>at BSL2 level yields high accuracy in 15 days from sputum processing
Direct thin-layer agar for bedaquiline-susceptibility testing of<i>Mycobacterium tuberculosis</i>at BSL2 level yields high accuracy in 15 days from sputum processing Open
This study evaluated thin-layer agar (TLA) as a faster alternative for both indirect MIC determination of bedaquiline (BDQ) from culture isolates and direct drug-susceptibility testing (DST) from sputum samples. Indirect BDQ-MIC results fr…
View article: Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site
Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site Open
Eliciting potent and broadly neutralizing antibodies (bnAbs) is a major goal in HIV-1 vaccine development. Here, we describe how germline-targeting immunogen BG505 SOSIP germline trimer 1.1 (GT1.1), generated through structure-based design…
View article: Safety of high-dose amikacin in the first week of all-oral rifampicin-resistant tuberculosis treatment for the prevention of acquired resistance (STAKE): protocol for a single-arm clinical trial
Safety of high-dose amikacin in the first week of all-oral rifampicin-resistant tuberculosis treatment for the prevention of acquired resistance (STAKE): protocol for a single-arm clinical trial Open
Introduction An effective rifampicin-resistant tuberculosis (RR-TB) treatment regimen should include prevention of resistance amplification. While bedaquiline (BDQ) has been recommended in all-oral RR-TB treatment regimen since 2019, resis…
View article: High Rates of False Rifampicin Resistance in Paucibacillary Tuberculosis Patients by Xpert MTB/RIF Ultra
High Rates of False Rifampicin Resistance in Paucibacillary Tuberculosis Patients by Xpert MTB/RIF Ultra Open
View article: Rifampicin Resistance Conferring Mutations among Mycobacterium tuberculosis Strains in Rwanda
Rifampicin Resistance Conferring Mutations among Mycobacterium tuberculosis Strains in Rwanda Open
Background: The World Health Organization-endorsed phenotypic and genotypic drug-susceptibility testing (gDST/pDST) assays for the detection of rifampicin-resistant (RR) tuberculosis (TB), may miss some clinically relevant rpoB mutants, in…
View article: A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike
A public antibody class recognizes an S2 epitope exposed on open conformations of SARS-CoV-2 spike Open
View article: A public antibody class recognizes a novel S2 epitope exposed on open conformations of SARS-CoV-2 spike
A public antibody class recognizes a novel S2 epitope exposed on open conformations of SARS-CoV-2 spike Open
Delineating the origins and properties of antibodies elicited by SARS-CoV-2 infection and vaccination is critical for understanding their benefits and potential shortcomings. Therefore, we investigated the SARS-CoV-2 spike (S)-reactive B c…
View article: Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination
Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination Open
Antibodies of convalescent COVID-19 patients and vaccine recipients show reduced recognition of SARS-CoV-2 variants of concern.
View article: Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination
Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination Open
Emerging SARS-CoV-2 variants pose a threat to human immunity induced by natural infection and vaccination. We assessed the recognition of three variants of concern (B.1.1.7, B.1.351 and P.1) in cohorts of COVID-19 patients ranging in disea…