Isabel Holguera
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View article: Gene expression cartography of a developing neuronal structure
Gene expression cartography of a developing neuronal structure Open
The brain is a complex structure comprising thousands to billions of neurons that belong to thousands to millions of different neuronal types. These neurons often come from different progenitor domains and have very diverse developmental h…
View article: Temporal and Notch identity determine layer targeting and synapse location of medulla neurons
Temporal and Notch identity determine layer targeting and synapse location of medulla neurons Open
How specification mechanisms that generate neural diversity translate into specific neuronal targeting, connectivity, and function in the adult brain is not understood. In the medulla region of the Drosophila optic lobe, neural progenitors…
View article: Establishment of terminal selector combinations in optic lobe neurons
Establishment of terminal selector combinations in optic lobe neurons Open
The medulla is the part of the Drosophila optic lobe with the greatest neuronal diversity, in which the identity of each neuronal type is specified in progenitors and newborn neurons via the integration of temporal, spatial, and Notch-driv…
View article: Whole genome sequence of a long-legged fly Condylostylus longicornis from Hawaiʻi
Whole genome sequence of a long-legged fly Condylostylus longicornis from Hawaiʻi Open
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View article: Coordinated control of neuronal differentiation and wiring by sustained transcription factors
Coordinated control of neuronal differentiation and wiring by sustained transcription factors Open
The large diversity of cell types in nervous systems presents a challenge in identifying the genetic mechanisms that encode it. Here, we report that nearly 200 distinct neurons in the Drosophila visual system can each be defined by unique …
View article: Coordinated control of neuronal differentiation and wiring by a sustained code of transcription factors
Coordinated control of neuronal differentiation and wiring by a sustained code of transcription factors Open
The enormous diversity of cell types in nervous systems presents a challenge in identifying the genetic mechanisms that encode it. Here, we report that nearly 200 distinct neurons in the Drosophila visual system can each be defined by uniq…
View article: R7 photoreceptor axon targeting depends on the relative levels of lost and found expression in R7 and its synaptic partners
R7 photoreceptor axon targeting depends on the relative levels of lost and found expression in R7 and its synaptic partners Open
As neural circuits form, growing processes select the correct synaptic partners through interactions between cell surface proteins. The presence of such proteins on two neuronal processes may lead to either adhesion or repulsion; however, …
View article: Author response: R7 photoreceptor axon targeting depends on the relative levels of lost and found expression in R7 and its synaptic partners
Author response: R7 photoreceptor axon targeting depends on the relative levels of lost and found expression in R7 and its synaptic partners Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract As neural circuits form, grow…
View article: Decision letter: A developmental framework linking neurogenesis and circuit formation in the Drosophila CNS
Decision letter: A developmental framework linking neurogenesis and circuit formation in the Drosophila CNS Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The mechanisms specifying neuronal diversi…
View article: R7 photoreceptor axon targeting depends on the relative levels of<i>lost and found</i>expression in R7 and its synaptic partners
R7 photoreceptor axon targeting depends on the relative levels of<i>lost and found</i>expression in R7 and its synaptic partners Open
As neural circuits form, growing processes select the correct synaptic partners through interactions between cell surface proteins. The presence of such proteins on two neuronal processes may lead to either adhesion or repulsion; however, …
View article: Neuronal specification in space and time
Neuronal specification in space and time Open
To understand how neurons assemble to form functional circuits, it is necessary to obtain a detailed knowledge of their diversity and to define the developmental specification programs that give rise to this diversity. Invertebrates and ve…
View article: DNA-Binding Proteins Essential for Protein-Primed Bacteriophage Φ29 DNA Replication
DNA-Binding Proteins Essential for Protein-Primed Bacteriophage Φ29 DNA Replication Open
Bacillus subtilis phage Φ29 has a linear, double-stranded DNA 19 kb long with an inverted terminal repeat of 6 nucleotides and a protein covalently linked to the 5' ends of the DNA. This protein, called terminal protein (TP), is the primer…