Isabel K. Kim
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View article: Predicting the invasiveness of threshold-dependent gene drives
Predicting the invasiveness of threshold-dependent gene drives Open
Gene drives hold great promise for controlling disease vectors or invasive species due to their capacity to rapidly spread through a population from a small initial release. This same property also raises serious concerns about unintended …
View article: Gene drive dynamics in plants: the role of seedbanks
Gene drive dynamics in plants: the role of seedbanks Open
Gene drives offer revolutionary potential for the management of problematic plant populations, such as invasive weeds and herbicide-resistant species, by rapidly spreading desired genetic alterations. Two recent studies have provided the f…
View article: Population dynamics in spatial suppression gene drive models and the effect of resistance, density dependence, and life history
Population dynamics in spatial suppression gene drive models and the effect of resistance, density dependence, and life history Open
Due to their super-Mendelian inheritance, gene drive systems have the potential to provide revolutionary solutions to critical public health and environmental problems. For suppression drives, however, spatial structure can cause “chasing”…
View article: Anopheles homing suppression drive candidates exhibit unexpected performance differences in simulations with spatial structure
Anopheles homing suppression drive candidates exhibit unexpected performance differences in simulations with spatial structure Open
Recent experiments have produced several Anopheles gambiae homing gene drives that disrupt female fertility genes, thereby eventually inducing population collapse. Such drives may be highly effective tools to combat malaria. One such homin…
View article: Author response: Anopheles homing suppression drive candidates exhibit unexpected performance differences in simulations with spatial structure
Author response: Anopheles homing suppression drive candidates exhibit unexpected performance differences in simulations with spatial structure Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Recent expe…
View article: Finding the strongest gene drive: Simulations reveal unexpected performance differences between <i>Anopheles</i> homing suppression drive candidates
Finding the strongest gene drive: Simulations reveal unexpected performance differences between <i>Anopheles</i> homing suppression drive candidates Open
Recent experiments have produced several Anopheles gambiae homing gene drives that disrupt female fertility genes, thereby eventually inducing population collapse. Such drives may be highly effective tools to combat malaria. One such homin…
View article: Suppression gene drive in continuous space can result in unstable persistence of both drive and wild‐type alleles
Suppression gene drive in continuous space can result in unstable persistence of both drive and wild‐type alleles Open
Rapid evolutionary processes can produce drastically different outcomes when studied in panmictic population models vs. spatial models. One such process is gene drive, which describes the spread of “selfish” genetic elements through a popu…
View article: Design and analysis of CRISPR‐based underdominance toxin‐antidote gene drives
Design and analysis of CRISPR‐based underdominance toxin‐antidote gene drives Open
CRISPR gene drive systems offer a mechanism for transmitting a desirable transgene throughout a population for purposes ranging from vector‐borne disease control to invasive species suppression. In this simulation study, we assess the perf…
View article: Performance analysis of novel toxin-antidote CRISPR gene drive systems
Performance analysis of novel toxin-antidote CRISPR gene drive systems Open