Isabel Prucker
YOU?
Author Swipe
View article: Metabolic silencing induced by the small bacterial membrane protein YohP
Metabolic silencing induced by the small bacterial membrane protein YohP Open
View article: From Pharmacophore to Warhead: NAD <sup>+</sup> ‐Targeting Triazoles as Mechanism‐Based Sirtuin Inhibitors
From Pharmacophore to Warhead: NAD <sup>+</sup> ‐Targeting Triazoles as Mechanism‐Based Sirtuin Inhibitors Open
Sirtuins (SIRTs) are nicotinamide adenine dinucleotide (NAD + )‐dependent lysine deacylases linked to key physiological and disease processes. Here, we report a new class of mechanism‐based 1,2,3‐triazole inhibitors that hijack SIRT cataly…
View article: From Pharmacophore to Warhead: NAD <sup>+</sup> ‐Targeting Triazoles as Mechanism‐Based Sirtuin Inhibitors
From Pharmacophore to Warhead: NAD <sup>+</sup> ‐Targeting Triazoles as Mechanism‐Based Sirtuin Inhibitors Open
Sirtuins (SIRTs) are nicotinamide adenine dinucleotide (NAD + )‐dependent lysine deacylases linked to key physiological and disease processes. Here, we report a new class of mechanism‐based 1,2,3‐triazole inhibitors that hijack SIRT cataly…
View article: NUDIX hydrolases target specific inositol pyrophosphates and regulate phosphate homeostasis and bacterial pathogen susceptibility in Arabidopsis
NUDIX hydrolases target specific inositol pyrophosphates and regulate phosphate homeostasis and bacterial pathogen susceptibility in Arabidopsis Open
Inositol pyrophosphates (PP‐InsPs) are important signaling molecules that regulate diverse cellular processes in eukaryotes, including energy homeostasis, phosphate (P i ) signaling, and phytohormone perception. Yet, in plants, the enzymes…
View article: Controlled Delivery and Light-Induced Release of Magic Spot Nucleotides in <i>Escherichia coli</i>
Controlled Delivery and Light-Induced Release of Magic Spot Nucleotides in <i>Escherichia coli</i> Open
The “magic spot nucleotides” (MSNs) ppGpp and pppGpp (also: (p)ppGpp) are bacterial alarmones central to the conserved stringent response, a stress adaptation mechanism that helps bacteria adapt to stress conditions and hostile environment…
View article: The small membrane protein YohP induces membrane depolarization and ppGpp accumulation in <i>Escherichia coli</i>
The small membrane protein YohP induces membrane depolarization and ppGpp accumulation in <i>Escherichia coli</i> Open
Summary Small membrane proteins represent an abundant and ubiquitous class of proteins that are often up-regulated when cells encounter unfavorable conditions, yet details about their exact function are largely missing. In bacteria, these …
View article: Tandem inactivation of inositol pyrophosphatases Asp1, Siw14, and Aps1 illuminates functional redundancies in inositol pyrophosphate catabolism in fission yeast
Tandem inactivation of inositol pyrophosphatases Asp1, Siw14, and Aps1 illuminates functional redundancies in inositol pyrophosphate catabolism in fission yeast Open
Inositol pyrophosphates 5-IP 7 , 1-IP 7 , and 1,5-IP 8 are eukaryal signaling molecules that influence cell physiology, especially phosphate homeostasis. In fission yeast, 1,5-IP 8 and 1-IP 7 impact gene expression by acting as agonists of…
View article: Biochemical and biophysical characterization of inositol-tetrakisphosphate 1-kinase inhibitors
Biochemical and biophysical characterization of inositol-tetrakisphosphate 1-kinase inhibitors Open
Inositol phosphates (IPs) and inositol pyrophosphate play critical roles in many biological processes such as signaling molecules in pathways responsible for cellular functions involved in growth and maintenance. The biosynthesis of IPs is…
View article: Structural Insights into Broad‐Range Polyphosphate Kinase 2‐II Enzymes Applicable for Pyrimidine Nucleoside Diphosphate Synthesis
Structural Insights into Broad‐Range Polyphosphate Kinase 2‐II Enzymes Applicable for Pyrimidine Nucleoside Diphosphate Synthesis Open
Polyphosphate kinases (PPK) play crucial roles in various biological processes, including energy storage and stress responses, through their interaction with inorganic polyphosphate (polyP) and the intracellular nucleotide pool. Members of…
View article: Structural Insights into Broad-Range Polyphosphate Kinase 2-II Enzymes Applicable for Pyrimidine Nucleoside Diphosphate Synthesis
Structural Insights into Broad-Range Polyphosphate Kinase 2-II Enzymes Applicable for Pyrimidine Nucleoside Diphosphate Synthesis Open
Polyphosphate kinases (PPK) play crucial roles in various biological processes, including energy storage and stress responses, through their interaction with inorganic polyphosphate (polyP) and the intracellular nucleotide pool. Members of…
View article: Activities and genetic interactions of fission yeast Aps1, a Nudix-type inositol pyrophosphatase and inorganic polyphosphatase
Activities and genetic interactions of fission yeast Aps1, a Nudix-type inositol pyrophosphatase and inorganic polyphosphatase Open
Inositol pyrophosphate 1,5-IP 8 regulates expression of a fission yeast phosphate homeostasis regulon, comprising phosphate acquisition genes pho1 , pho84 , and tgp1 , via its action as an agonist of precocious termination of transcription…
View article: β-lapachone regulates mammalian inositol pyrophosphate levels in an NQO1- and oxygen-dependent manner
β-lapachone regulates mammalian inositol pyrophosphate levels in an NQO1- and oxygen-dependent manner Open
Inositol pyrophosphates (PP-InsPs) are energetic signaling molecules with important functions in mammals. As their biosynthesis depends on ATP concentration, PP-InsPs are tightly connected to cellular energy homeostasis. Consequently, an i…
View article: Bacterial Pathogen Infection Triggers Magic Spot Nucleotide Signaling in <i>Arabidopsis thaliana</i> Chloroplasts through Specific RelA/SpoT Homologues
Bacterial Pathogen Infection Triggers Magic Spot Nucleotide Signaling in <i>Arabidopsis thaliana</i> Chloroplasts through Specific RelA/SpoT Homologues Open
Magic spot nucleotides (p)ppGpp are important signaling molecules in bacteria and plants. In the latter, RelA-SpoT homologue (RSH) enzymes are responsible for (p)ppGpp turnover. Profiling of (p)ppGpp is more difficult in plants than in bac…
View article: Bacterial Pathogen Infection Triggers Magic Spot Nucleotide Signaling in<i>Arabidopsis thaliana</i>Chloroplasts Through Specific RelA/SpoT Homologs
Bacterial Pathogen Infection Triggers Magic Spot Nucleotide Signaling in<i>Arabidopsis thaliana</i>Chloroplasts Through Specific RelA/SpoT Homologs Open
Magic spot nucleotides (p)ppGpp are important signaling molecules in bacteria and plants. In the latter, RSH enzymes are responsible for (p)ppGpp turnover. Profiling of (p)ppGpp is more difficult in plants than in bacteria due to lower con…
View article: β-Lapachone Regulates Mammalian Inositol Pyrophosphate Levels in an NQO1- and Oxygen-dependent Manner
β-Lapachone Regulates Mammalian Inositol Pyrophosphate Levels in an NQO1- and Oxygen-dependent Manner Open
1 Abstract Inositol pyrophosphates (PP-InsPs) are energetic signalling molecules with important functions in mammals. As their biosynthesis depends on ATP concentration, PP-InsPs are tightly connected to cellular energy homeostasis. Conseq…
View article: Photoaffinity Capture Compounds to Profile the Magic Spot Nucleotide Interactomes**
Photoaffinity Capture Compounds to Profile the Magic Spot Nucleotide Interactomes** Open
Magic Spot Nucleotides (MSN) regulate the stringent response, a highly conserved bacterial stress adaptation mechanism, enabling survival under adverse external challenges. In times of antibiotic crisis, a detailed understanding of stringe…
View article: Photoaffinity Capture Compounds to Profile the Magic Spot Nucleotide Interactomes**
Photoaffinity Capture Compounds to Profile the Magic Spot Nucleotide Interactomes** Open
Magic Spot Nucleotides (MSN) regulate the stringent response, a highly conserved bacterial stress adaptation mechanism, enabling survival under adverse external challenges. In times of antibiotic crisis, a detailed understanding of stringe…
View article: Photoaffinity capture compounds to profile the Magic Spot Nucleotide interactomes
Photoaffinity capture compounds to profile the Magic Spot Nucleotide interactomes Open
Magic Spot Nucleotides (MSN) regulate the stringent response, a highly conserved bacterial stress adaptation mechanism, enabling survival when confronted with adverse external challenges. In times of antibiotic crisis, a detailed understan…