Isabel R. A. Retel Helmrich

Facilitators and Barriers of the Use of Prognostic Models for Clinical Decision Making in Acute Neurologic Care: A Systematic Review Open

Ellen Hu, Evelien S. van Hoorn, Isabel R. A. Retel Helmrich, Susanne Muehlschlegel, Judith Rietjens , et al. · 2025

Background Prognostic models are crucial for predicting patient outcomes and aiding clinical decision making. Despite their availability in acute neurologic care, their use in clinical practice is limited, with insufficient reflection on r…

An exploration of the perspectives of Dutch adults experiencing a genetic condition on human germline gene editing Open

Sophie Arnold, Diewertje Houtman, Isabel R. A. Retel Helmrich, Sander R. Hilberink, Sam Riedijk · 2025

A decade of public engagement regarding human germline gene editing: a systematic scoping review Open

Wendy P. Geuverink, Diewertje Houtman, Isabel R. A. Retel Helmrich, Joosje D. Kist, Lidewij Henneman , et al. · 2024

Following the discovery of the CRISPR-Cas technology in 2012, there has been a growing global call for public engagement regarding the potential use of human germline gene editing (HGGE). In this systematic scoping review, we aim to evalua…

The need to set explicit goals for human germline gene editing public dialogues Open

Wendy P. Geuverink, Diewertje Houtman, Isabel R. A. Retel Helmrich, Sophie van Baalen, B.C. van Beers , et al. · 2024

Given the potentially large ethical and societal implications of human germline gene editing (HGGE) the urgent need for public and stakeholder engagement (PSE) has been repeatedly expressed. However, the explicit goals of such PSE efforts …

“What if” should precede “whether” and “how” in the social conversation around human germline gene editing Open

Diewertje Houtman, Wendy P. Geuverink, Isabel R. A. Retel Helmrich, Boy Vijlbrief, Martina C. Cornel , et al. · 2023

Mortality Prediction in Severe Traumatic Brain Injury Using Traditional and Machine Learning Algorithms Open

Xiang Wu, Yuyao Sun, Xiao Xu, Ewout W. Steyerberg, Isabel R. A. Retel Helmrich , et al. · 2023

Abstract Prognostic prediction of traumatic brain injury (TBI) in patients is crucial in clinical decision and health care policy making. This study aimed to develop and validate prediction models for in-hospital mortality after sev…

US and Dutch Perspectives on the Use of COVID-19 Clinical Prediction Models: Findings from a Qualitative Analysis Open

Melissa Basile, Isabel R. A. Retel Helmrich, Jinny G. Park, Jennifer Polo, Judith Rietjens , et al. · 2023

Introduction Clinical prediction models (CPMs) for coronavirus disease 2019 (COVID-19) may support clinical decision making, treatment, and communication. However, attitudes about using CPMs for COVID-19 decision making are unknown. Method…

Prognostic models for COVID-19 needed updating to warrant transportability over time and space Open

David van Klaveren, Theodoros P. Zanos, Jason Nelson, Todd Levy, Jinny G. Park , et al. · 2022

Incremental prognostic value of acute serum biomarkers for functional outcome after traumatic brain injury (CENTER-TBI): an observational cohort study Open

Isabel R. A. Retel Helmrich, Endre Czeiter, Krisztina Amrein, András Büki, Hester F. Lingsma , et al. · 2022

European Union's Seventh Framework Programme, Hannelore Kohl Stiftung, OneMind, Integra LifeSciences, and NeuroTrauma Sciences.

Health care utilization and outcomes in older adults after Traumatic Brain Injury: A CENTER-TBI study Open

Marjolein van der Vlegel, Ana Mikolić, Quentin Lee Hee, Z Kaplan, Isabel R. A. Retel Helmrich , et al. · 2022

Discrepancy between disability and reported well-being after traumatic brain injury Open

Isabel R. A. Retel Helmrich, David van Klaveren, Nada Anđelić, Hester F. Lingsma, Andrew I.R. Maas , et al. · 2022

Background Following traumatic brain injury (TBI), the clinical focus is often on disability. However, patients’ perceptions of well-being can be discordant with their disability level, referred to as the ‘disability paradox’. We aimed to …

Serum metabolome associated with severity of acute traumatic brain injury Open

Ilias Thomas, Alex M. Dickens, Jussi P. Posti, Endre Czeiter, Daniel Duberg , et al. · 2022

Does poor methodological quality of prediction modeling studies translate to poor model performance? An illustration in traumatic brain injury Open

Isabel R. A. Retel Helmrich, Ana Mikolić, David M. Kent, Hester F. Lingsma, Laure Wynants , et al. · 2022

Development of prognostic models for Health-Related Quality of Life following traumatic brain injury Open

Isabel R. A. Retel Helmrich, David van Klaveren, Simone A. Dijkland, Hester F. Lingsma, Suzanne Polinder , et al. · 2021

Background Traumatic brain injury (TBI) is a leading cause of impairments affecting Health-Related Quality of Life (HRQoL). We aimed to identify predictors of and develop prognostic models for HRQoL following TBI. Methods We used data from…

Outcome Prediction after Moderate and Severe Traumatic Brain Injury: External Validation of Two Established Prognostic Models in 1742 European Patients Open

Simone A. Dijkland, Isabel R. A. Retel Helmrich, Daan Nieboer, Mathieu van der Jagt, Diederik W.J. Dippel , et al. · 2020

The International Mission on Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) and Corticoid Randomisation After Significant Head injury (CRASH) prognostic models predict functional outcome after moderate and sev…

Prediction of Global Functional Outcome and Post-Concussive Symptoms after Mild Traumatic Brain Injury: External Validation of Prognostic Models in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study Open

Ana Mikolić, Suzanne Polinder, Ewout W. Steyerberg, Isabel R. A. Retel Helmrich, Joseph T. Giacino , et al. · 2020

The majority of traumatic brain injuries (TBIs) are categorized as mild, according to a baseline Glasgow Coma Scale (GCS) score of 13-15. Prognostic models that were developed to predict functional outcome and persistent post-concussive sy…

Prognostic Research in Traumatic Brain Injury: Markers, Modeling, and Methodological Principles Open

Isabel R. A. Retel Helmrich, Hester F. Lingsma, Alexis F. Turgeon, José‐Miguel Yamal, Ewout W. Steyerberg · 2020

Prognostic assessment in traumatic brain injury (TBI) is embedded deeply in clinical care. Considering the limitations of current prognostic indicators, there is increasing interest in understanding the role of new biomarkers, and in findi…

Validation of prognostic models: challenges and opportunities Open

Simone A. Dijkland, Isabel R. A. Retel Helmrich, Ewout W. Steyerberg · 2018

Multivariable prognostic models combine several \ncharacteristics to provide predictions for individual patients. \nPrognostic models can be applied in research and clinical \npractice, for instance to assist clinicians with decisions \nre…

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