Isabel Rollán
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View article: Pluripotency factors regulate the onset of <i>Hox</i> cluster activation in the early embryo
Pluripotency factors regulate the onset of <i>Hox</i> cluster activation in the early embryo Open
Pluripotent cells are a transient population of the mammalian embryo dependent on transcription factors, such as OCT4 and NANOG, which maintain pluripotency while suppressing lineage specification. However, these factors are also expressed…
View article: Systematic in vivo interrogation identifies novel enhancers and silencers associated to Atrial Fibrillation
Systematic in vivo interrogation identifies novel enhancers and silencers associated to Atrial Fibrillation Open
Cis-regulatory elements control gene expression in time and space and their disruption can lead to pathologies. Reporter assays allow the functional validation of enhancers and other regulatory elements, and such assays by means of the gen…
View article: <i>Nanog</i> regulates <i>Pou3f1</i> expression at the exit from pluripotency during gastrulation
<i>Nanog</i> regulates <i>Pou3f1</i> expression at the exit from pluripotency during gastrulation Open
Pluripotency is regulated by a network of transcription factors that maintain early embryonic cells in an undifferentiated state while allowing them to proliferate. NANOG is a critical factor for maintaining pluripotency and its role in pr…
View article: Transitions in cell potency during early mouse development are driven by Notch
Transitions in cell potency during early mouse development are driven by Notch Open
The Notch signalling pathway plays fundamental roles in diverse developmental processes in metazoans, where it is important in driving cell fate and directing differentiation of various cell types. However, we still have limited knowledge …
View article: <i>Nanog</i> regulates <i>Pou3f1</i> expression and represses anterior fate at the exit from pluripotency
<i>Nanog</i> regulates <i>Pou3f1</i> expression and represses anterior fate at the exit from pluripotency Open
Pluripotency is regulated by a network of transcription factors that maintains early embryonic cells in an undifferentiated state while allowing them to proliferate. NANOG is a critical factor for maintaining pluripotency and its role in p…
View article: Author response: Transitions in cell potency during early mouse development are driven by Notch
Author response: Transitions in cell potency during early mouse development are driven by Notch Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The Notch signalling pathway …
View article: Pluripotency factors regulate the onset of Hox cluster activation in the early embryo
Pluripotency factors regulate the onset of Hox cluster activation in the early embryo Open
Pluripotent cells are a transient population present in the early mammalian embryo dependent on transcription factors, such as OCT4 and NANOG, which maintain pluripotency while simultaneously suppressing lineage specification. Interestingl…
View article: The pluripotency factor <scp>NANOG</scp> controls primitive hematopoiesis and directly regulates <i>Tal1</i>
The pluripotency factor <span>NANOG</span> controls primitive hematopoiesis and directly regulates <i>Tal1</i> Open
Progenitors of the first hematopoietic cells in the mouse arise in the early embryo from Brachyury-positive multipotent cells in the posterior-proximal region of the epiblast, but the mechanisms that specify primitive blood cells ar…
View article: Transitions in cell potency during early mouse development are driven by Notch
Transitions in cell potency during early mouse development are driven by Notch Open
The Notch signalling pathway plays fundamental roles in diverse developmental processes in metazoans, where it is important in driving cell fate and directing differentiation of various cell types. However, we still have limited knowledge …
View article: CTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart
CTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart Open
Cardiac progenitors are specified early in development and progressively differentiate and mature into fully functional cardiomyocytes. This process is controlled by an extensively studied transcriptional program. However, the regulatory e…
View article: Distinct mechanisms regulate Cdx2 expression in the blastocyst and in trophoblast stem cells
Distinct mechanisms regulate Cdx2 expression in the blastocyst and in trophoblast stem cells Open
View article: Long-range regulatory interactions at the 4q25 atrial fibrillation risk locus involve PITX2c and ENPEP
Long-range regulatory interactions at the 4q25 atrial fibrillation risk locus involve PITX2c and ENPEP Open
Our data suggest that de-regulation of both PITX2 and ENPEP could contribute to an increased risk of atrial fibrillation in carriers of disease-associated variants, and show the challenges that we face in the functional analysis of genome-…