Isabel Sarty
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View article: The IL‐18 signaling cascade is implicated in aging, tau pathology and synaptic degeneration
The IL‐18 signaling cascade is implicated in aging, tau pathology and synaptic degeneration Open
Background Emerging evidence suggests a bidirectional role of inflammation in Alzheimer's Disease (AD), possibly protecting against amyloid deposition early but exacerbating later tau‐related injury. The NLRP3 inflammasome, a driver of “in…
View article: Longitudinal association between CSF markers of Alzheimer Disease and inflammation in preclinical Alzheimer Disease
Longitudinal association between CSF markers of Alzheimer Disease and inflammation in preclinical Alzheimer Disease Open
Background Inflammation is central to Alzheimer Disease (AD), as astrocyte reactivity accompanies the appearance of Aβ and phosphorylated tau (Bellaver et al., 2023). As expected, therefore, AD patients have elevated levels of CSF inflamma…
View article: Reducing CETP activity prevents memory decline in an Alzheimer’s disease mouse model
Reducing CETP activity prevents memory decline in an Alzheimer’s disease mouse model Open
Epidemiological studies have shown that lower activity of the cholesteryl ester transfer protein (CETP) correlates with reduced Alzheimer’s disease (AD) risk. While small molecule CETP inhibitors like evacetrapib have previously been asses…
View article: Associations between neuromelanin depletion and cortical rhythmic activity in Parkinson’s disease
Associations between neuromelanin depletion and cortical rhythmic activity in Parkinson’s disease Open
Parkinson’s disease (PD) is marked by the death of neuromelanin-rich dopaminergic and noradrenergic cells in the substantia nigra (SN) and the locus coeruleus (LC), respectively, resulting in motor and cognitive impairments. Although SN do…