Isabela Alvim
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View article: Genetics of Latin American Diversity Project: Insights into population genetics and association studies in admixed groups in the Americas
Genetics of Latin American Diversity Project: Insights into population genetics and association studies in admixed groups in the Americas Open
View article: Genetics of Latin American Diversity Project: Insights into population genetics and association studies in admixed groups in the Americas
Genetics of Latin American Diversity Project: Insights into population genetics and association studies in admixed groups in the Americas Open
Latin Americans are underrepresented in genetic studies, increasing disparities in personalized genomic medicine. Despite available genetic data from thousands of Latin Americans, accessing and navigating the bureaucratic hurdles for conse…
View article: Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass and fat mass indexes
Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass and fat mass indexes Open
View article: Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2-rs2070788, associated with severe influenza, and its population genetics caveats in Native Americans
Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2-rs2070788, associated with severe influenza, and its population genetics caveats in Native Americans Open
For human/SARS-CoV-2 interactome genes ACE2, TMPRSS2 and BSG, there is a convincing evidence of association in Asians with influenza-induced SARS for TMPRSS2-rs2070788, tag-SNP of the eQTL rs383510. This case illustrates the importance of …
View article: Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2-rs2070788, associated with severe influenza, and its population genetics caveats in Native Americans
Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2-rs2070788, associated with severe influenza, and its population genetics caveats in Native Americans Open
For human/SARS-CoV-2 interactome genes ACE2, TMPRSS2 and BSG, there is a convincing evidence of association in Asians with influenza-induced SARS for TMPRSS2-rs2070788, tag-SNP of the eQTL rs383510. This case illustrates the importance of …
View article: The genetic structure and adaptation of Andean highlanders and Amazonians are influenced by the interplay between geography and culture
The genetic structure and adaptation of Andean highlanders and Amazonians are influenced by the interplay between geography and culture Open
Significance Native Americans are neglected in human genetics studies, despite recent interest in the study of ancient DNA of their ancestors. Our findings on Andean and Amazonian populations exemplify how the current pattern of genetic di…
View article: Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2-rs2070788, associated with severe influenza, and its population genetics caveats in Native Americans
Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2-rs2070788, associated with severe influenza, and its population genetics caveats in Native Americans Open
The current search for host-susceptibility variants for COVID-19 contrasts with the fact that the study of the genetic architecture of Severe Acute Respiratory Syndrome (SARS) has been neglected. For human/SARS-CoV-2 interactome genes ACE2…
View article: Origins, Admixture Dynamics, and Homogenization of the African Gene Pool in the Americas
Origins, Admixture Dynamics, and Homogenization of the African Gene Pool in the Americas Open
The Transatlantic Slave Trade transported more than 9 million Africans to the Americas between the early 16th and the mid-19th centuries. We performed a genome-wide analysis using 6,267 individuals from 25 populations to infer how differen…
View article: The genetic structure and adaptation of Andean highlanders and Amazonian dwellers is influenced by the interplay between geography and culture
The genetic structure and adaptation of Andean highlanders and Amazonian dwellers is influenced by the interplay between geography and culture Open
Western South America was one of the worldwide cradles of civilization. The well known Inca Empire was the tip of the iceberg of a cultural and biological evolutionary process that started 14-11 thousand years ago. Genetic data from 18 Per…
View article: Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass- and fat mass-indexes
Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass- and fat mass-indexes Open
Admixed populations are a resource to study the global genetic architecture of complex phenotypes, which is critical, considering that non-European populations are severely under-represented in genomic studies. Leveraging admixture in Braz…
View article: Ancestralidade e casamentos preferenciais em populações brasileiras
Ancestralidade e casamentos preferenciais em populações brasileiras Open
Populacoes humanas apresentam uma tendencia para casamentos entre individuos com status socioeconomico, nivel de escolaridade e ancestralidade genomica similar. Esse comportamento viola asuposicao de casamentos aleatorios de varios modelos…