Isabella P. Fallon
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View article: Striatal Pathways for Action Counting and Steering
Striatal Pathways for Action Counting and Steering Open
The basal ganglia (BG) are critical for coordinating voluntary movements, yet their precise contribution remains a subject of debate. Using a novel operant counting task, we trained mice to perform a specific number of lever presses to obt…
View article: Dopamine dynamics during stimulus-reward learning in mice can be explained by performance rather than learning
Dopamine dynamics during stimulus-reward learning in mice can be explained by performance rather than learning Open
The reward prediction error (RPE) hypothesis posits that phasic dopamine (DA) activity in the ventral tegmental area (VTA) encodes the difference between expected and actual rewards to drive reinforcement learning. However, emerging eviden…
View article: Facilitation of Ca<sub>V</sub>3.2 channel gating in pain pathways reveals a novel mechanism of serum-induced hyperalgesia
Facilitation of Ca<sub>V</sub>3.2 channel gating in pain pathways reveals a novel mechanism of serum-induced hyperalgesia Open
The Ca V 3.2 isoform of T-type voltage-gated calcium channels plays a crucial role in regulating the excitability of nociceptive neurons; the endogenous molecules that modulate its activity, however, remain poorly understood. Here, we used…
View article: Force tuning explains changes in phasic dopamine signaling during stimulus-reward learning
Force tuning explains changes in phasic dopamine signaling during stimulus-reward learning Open
According to a popular hypothesis, phasic dopamine (DA) activity encodes a reward prediction error (RPE) necessary for reinforcement learning. However, recent work showed that DA neurons are necessary for performance rather than learning. …
View article: Elucidating a locus coeruleus-dentate gyrus dopamine pathway for operant reinforcement
Elucidating a locus coeruleus-dentate gyrus dopamine pathway for operant reinforcement Open
Animals can learn to repeat behaviors to earn desired rewards, a process commonly known as reinforcement learning. While previous work has implicated the ascending dopaminergic projections to the basal ganglia in reinforcement learning, li…
View article: <strong>The role of the parafascicular thalamic nucleus in action initiation and steering. Data files. </strong>
<strong>The role of the parafascicular thalamic nucleus in action initiation and steering. Data files. </strong> Open
Excel files represent all data points in all of the figures. Data excels were exported from GraphPad (Prisim) software.
View article: Elucidating a locus coeruleus-hippocampal dopamine pathway for operant reinforcement
Elucidating a locus coeruleus-hippocampal dopamine pathway for operant reinforcement Open
Animals can learn to repeat behaviors to earn desired rewards, a process commonly known as reinforcement learning. While previous work has implicated the ascending dopaminergic projections to the basal ganglia in reinforcement learning, li…
View article: All-optical imaging and patterned stimulation with a one-photon endoscope
All-optical imaging and patterned stimulation with a one-photon endoscope Open
While in vivo calcium imaging makes it possible to record activity in defined neuronal populations with cellular resolution, optogenetics allows selective manipulation of neural activity. Recently, these two tools have been combined to sti…
View article: Thalamic projections to the subthalamic nucleus contribute to movement initiation and rescue of parkinsonian symptoms
Thalamic projections to the subthalamic nucleus contribute to movement initiation and rescue of parkinsonian symptoms Open
Selective activation of Pf-STN pathway initiates actions in normal mice and restores movement in a mouse model of PD.
View article: Sex differences in resilience: Experiential factors and their mechanisms
Sex differences in resilience: Experiential factors and their mechanisms Open
Adverse life events can lead to stable changes in brain structure and function and are considered primary sources of risk for post‐traumatic stress disorder, depression and other neuropsychiatric disorders. However, most individuals do not…
View article: Data for: Voluntary exercise enables stress resistance in females
Data for: Voluntary exercise enables stress resistance in females Open
Data set for Tanner et al. Behavioral Brain Research
View article: Behavioural and neural sequelae of stressor exposure are not modulated by controllability in females
Behavioural and neural sequelae of stressor exposure are not modulated by controllability in females Open
The degree of behavioural control that an organism has over a stressor is a potent modulator of the stressor's impact; controllable stressors produce none of the neurochemical and behavioural sequelae that occur if the stressor is uncontro…
View article: Evaluating Stressor Controllability Effects in Female Rats
Evaluating Stressor Controllability Effects in Female Rats Open
Women are at a higher risk for developing neuropsychiatric conditions including generalized anxiety disorder, post-traumatic stress disorder, and depression. Moreover, traumatic life events may provoke disease development to a higher degre…