Isabella R. Pompa
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View article: First-Generation and Low-Income Students in the National Medical Student Body
First-Generation and Low-Income Students in the National Medical Student Body Open
Importance Diverse representation within the US medical student body and physician workforce is an important step to help address known pervasive health care disparities. Objective To evaluate US medical school first-year matriculants betw…
View article: US Cancer Mortality Trends Among Asian and Pacific Islander Populations
US Cancer Mortality Trends Among Asian and Pacific Islander Populations Open
Importance Cancer is the leading cause of death among Asian American individuals and the second leading cause of death among Native Hawaiian and Pacific Islander people. Objective To evaluate longitudinal cancer mortality trends from 1999 …
View article: Robustness of a Restriction Spectrum Imaging (RSI) quantitative MRI biomarker for prostate cancer: assessing for systematic bias due to age, race, ethnicity, prostate volume, medication use, or imaging acquisition parameters
Robustness of a Restriction Spectrum Imaging (RSI) quantitative MRI biomarker for prostate cancer: assessing for systematic bias due to age, race, ethnicity, prostate volume, medication use, or imaging acquisition parameters Open
Introduction Prostate multiparametric magnetic resonance imaging (mpMRI) has greatly improved the detection of clinically significant prostate cancer (csPCa). However, the limited number of expert sub-specialist radiologists capable of int…
View article: Restriction Spectrum Imaging as a quantitative biomarker for prostate cancer with reliable positive predictive value
Restriction Spectrum Imaging as a quantitative biomarker for prostate cancer with reliable positive predictive value Open
Background and Objective Positive predictive value of PI-RADS for clinically significant prostate cancer (csPCa, grade group [GG]≥2) varies widely between institutions and radiologists. The Restriction Spectrum Imaging restriction score (R…
View article: Longitudinal Analysis of Bladder Cancer-Specific Mortality Trends in the United States
Longitudinal Analysis of Bladder Cancer-Specific Mortality Trends in the United States Open
BACKGROUND: Bladder cancer is the tenth leading cause of cancer death in the United States (US). Advances in diagnosis, imaging, and treatments have led to improvements in bladder cancer management. OBJECTIVE: To evaluate longitudinal blad…
View article: US Cancer Mortality Trends Among Hispanic Populations From 1999 to 2020
US Cancer Mortality Trends Among Hispanic Populations From 1999 to 2020 Open
Importance Advances in cancer research and treatment access have led to decreasing cancer mortality in the US; however, cancer remains the leading cause of death among Hispanic individuals. Objective To evaluate longitudinal cancer mortali…
View article: Racial and ethnic disparities in a real-world precision oncology data registry
Racial and ethnic disparities in a real-world precision oncology data registry Open
Biorepositories enable precision oncology research by sharing clinically annotated genomic data, but it remains unknown whether these data registries reflect the true distribution of cancers in racial and ethnic minorities. Our analysis of…
View article: Novel plasma exosome biomarkers for prostate cancer progression in co-morbid metabolic disease
Novel plasma exosome biomarkers for prostate cancer progression in co-morbid metabolic disease Open
Comorbid Type 2 diabetes (T2D), a metabolic complication of obesity, associates with worse cancer outcomes for prostate, breast, head and neck, colorectal and several other solid tumors. However, the molecular mechanisms remain poorly unde…
View article: Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes
Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes Open
Exosomes from insulin-resistant adipocytes induce changes in breast cancer cells that promote metastasis.