Isabella R. Straub
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View article: Overexpression of the plastidial pseudo‐protease <scp>AtFtsHi3</scp> enhances drought tolerance while sustaining plant growth
Overexpression of the plastidial pseudo‐protease <span>AtFtsHi3</span> enhances drought tolerance while sustaining plant growth Open
With climate change, droughts are expected to be more frequent and severe, severely impacting plant biomass and quality. Here, we show that overexpressing the Arabidopsis gene AtFtsHi3 ( FtsHi3OE) enhances drought‐tolerant phenotypes witho…
View article: Overexpression of the plastidal pseudo-protease<i>AtFtsHi3</i>confers drought tolerance without penalizing growth
Overexpression of the plastidal pseudo-protease<i>AtFtsHi3</i>confers drought tolerance without penalizing growth Open
Drought is one of the most severe environmental stresses affecting plant biomass production and quality, however, the molecular mechanisms of drought response in plants remain unclear. Here, we demonstrate that overexpression of the Arabid…
View article: Antibody Characterization Report for Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial (CHCHD10)
Antibody Characterization Report for Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial (CHCHD10) Open
A peer-reviewed antibody characterization article corresponding to this Zenodo preprint is openly available at F1000Research: https://doi.org/10.12688/f1000research.151962.1 Head to head comparison of available commercial antibodies agains…
View article: Multi-OMICS study of a CHCHD10 variant causing ALS demonstrates metabolic rewiring and activation of endoplasmic reticulum and mitochondrial unfolded protein responses
Multi-OMICS study of a CHCHD10 variant causing ALS demonstrates metabolic rewiring and activation of endoplasmic reticulum and mitochondrial unfolded protein responses Open
Mutations in CHCHD10, coding for a mitochondrial intermembrane space protein, are a rare cause of autosomal dominant amyotrophic lateral sclerosis. Mutation-specific toxic gain of function or haploinsufficiency models have been proposed to…
View article: A CHCHD10 variant causing ALS elicits an unfolded protein response through the IRE1/XBP1 pathway
A CHCHD10 variant causing ALS elicits an unfolded protein response through the IRE1/XBP1 pathway Open
Mutations in CHCHD10 , coding for a mitochondrial intermembrane space protein, are a rare cause of autosomal dominant amyotrophic lateral sclerosis (ALS). Mutation-specific toxic gain of function or haploinsuffuciency models have been prop…
View article: Loss of CHCHD10–CHCHD2 complexes required for respiration underlies the pathogenicity of a CHCHD10 mutation in ALS
Loss of CHCHD10–CHCHD2 complexes required for respiration underlies the pathogenicity of a CHCHD10 mutation in ALS Open
Coiled-helix coiled-helix domain containing protein 10 (CHCHD10) and its paralogue CHCHD2 belong to a family of twin CX9C motif proteins, most of which localize to the intermembrane space of mitochondria. Dominant mutations in CHCHD10 caus…