Isabella Rusciano
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View article: Lamin B1 as a key modulator of the developing and aging brain
Lamin B1 as a key modulator of the developing and aging brain Open
Lamin B1 is an essential protein of the nuclear lamina that plays a crucial role in nuclear function and organization. It has been demonstrated that lamin B1 is essential for organogenesis and particularly brain development. The important …
View article: Understanding the Ultra-Rare Disease Autosomal Dominant Leukodystrophy: an Updated Review on Morpho-Functional Alterations Found in Experimental Models
Understanding the Ultra-Rare Disease Autosomal Dominant Leukodystrophy: an Updated Review on Morpho-Functional Alterations Found in Experimental Models Open
View article: Graphic medicine meets human anatomy: The potential role of comics in raising whole body donation awareness in Italy and beyond. A pilot study
Graphic medicine meets human anatomy: The potential role of comics in raising whole body donation awareness in Italy and beyond. A pilot study Open
Cadaver dissection has always played a fundamental role in medical education. However, especially in Italy, the topic of body donation has remained partially unknown for years. The current study analyses graphic medicine as a new possible …
View article: Impact of phospholipase C β1 in glioblastoma: a study on the main mechanisms of tumor aggressiveness
Impact of phospholipase C β1 in glioblastoma: a study on the main mechanisms of tumor aggressiveness Open
View article: The wide and growing range of lamin B-related diseases: from laminopathies to cancer
The wide and growing range of lamin B-related diseases: from laminopathies to cancer Open
B-type lamins are fundamental components of the nuclear lamina, a complex structure that acts as a scaffold for organization and function of the nucleus. Lamin B1 and B2, the most represented isoforms, are encoded by LMNB1 and LMNB2 gene, …
View article: Lamin B1 Accumulation’s Effects on Autosomal Dominant Leukodystrophy (ADLD): Induction of Reactivity in the Astrocytes
Lamin B1 Accumulation’s Effects on Autosomal Dominant Leukodystrophy (ADLD): Induction of Reactivity in the Astrocytes Open
Autosomal dominant leukodystrophy (ADLD) is an extremely rare and fatal neurodegenerative disease due to the overexpression of the nuclear lamina component Lamin B1. Many aspects of the pathology still remain unrevealed. This work highligh…
View article: Cell signaling pathways in autosomal-dominant leukodystrophy (ADLD): the intriguing role of the astrocytes
Cell signaling pathways in autosomal-dominant leukodystrophy (ADLD): the intriguing role of the astrocytes Open
View article: Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases
Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases Open
An increasing number of reports suggests a significant involvement of the phosphoinositide (PI) cycle in cancer development and progression. Diacylglycerol kinases (DGKs) are very active in the PI cycle. They are a family of ten members th…
View article: Phosphoinositide-Dependent Signaling in Cancer: A Focus on Phospholipase C Isozymes
Phosphoinositide-Dependent Signaling in Cancer: A Focus on Phospholipase C Isozymes Open
Phosphoinositides (PI) form just a minor portion of the total phospholipid content in cells but are significantly involved in cancer development and progression. In several cancer types, phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4…
View article: Nuclear Inositides and Inositide-Dependent Signaling Pathways in Myelodysplastic Syndromes
Nuclear Inositides and Inositide-Dependent Signaling Pathways in Myelodysplastic Syndromes Open
Myelodysplastic syndromes (MDS) are a heterogeneous group of hematological malignancies characterized by peripheral blood cytopenia and abnormal myeloproliferation, as well as a variable risk of evolution into acute myeloid leukemia (AML).…
View article: Phosphoinositide 3 Kinase Signaling in Human Stem Cells from Reprogramming to Differentiation: A Tale in Cytoplasmic and Nuclear Compartments
Phosphoinositide 3 Kinase Signaling in Human Stem Cells from Reprogramming to Differentiation: A Tale in Cytoplasmic and Nuclear Compartments Open
Stem cells are undifferentiated cells that can give rise to several different cell types and can self-renew. Given their ability to differentiate into different lineages, stem cells retain huge therapeutic potential for regenerative medici…