Isabella Sala
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View article: Osteoporosis in Severe Asthmatic Patients: Data from the Severe Asthma Network in Italy (SANI) Registry
Osteoporosis in Severe Asthmatic Patients: Data from the Severe Asthma Network in Italy (SANI) Registry Open
Background: Severe asthma is associated with an increased risk of osteoporosis, largely due to chronic corticosteroid exposure and persistent systemic inflammation. Data from different international registries indicate a significant preval…
View article: Fixed airway obstruction and bronchodilator responsiveness phenotypes in severe asthma population from SANI registry
Fixed airway obstruction and bronchodilator responsiveness phenotypes in severe asthma population from SANI registry Open
Background Data on asthma with fixed airway obstruction (FAO) are heterogeneous due to different and misleading definitions. Describing the FAO phenotype has significant implications for severe asthma (SA) comprehension. Objective To chara…
View article: Random Forest Regression for Predicting Healthcare Costs Using Administrative Databases from a Health Protection Agency in Northern Italy
Random Forest Regression for Predicting Healthcare Costs Using Administrative Databases from a Health Protection Agency in Northern Italy Open
INTRODUCTION Longer life expectancies and increasing prevalence of chronic diseases drive up demand for healthcare services and related costs. In Italy, 32% of people aged 65 and over, and 48% of those over 85, have major chronic condition…
View article: Heterogeneity of progression-free survival surrogacy by sex in randomized trials testing immunotherapy in non-small cell lung cancer
Heterogeneity of progression-free survival surrogacy by sex in randomized trials testing immunotherapy in non-small cell lung cancer Open
Background The surrogacy of progression-free survival (PFS) for overall survival (OS) at the trial-level in randomized clinical trials (RCTs) testing immune checkpoint inhibitors (ICIs) in patients with advanced non-small cell lung cancers…
View article: Surrogate endpoints for overall survival in randomized clinical trials testing antibody-drug conjugates
Surrogate endpoints for overall survival in randomized clinical trials testing antibody-drug conjugates Open
Background The surrogacy of overall response rate (ORR) or progression-free survival (PFS) for overall survival (OS) at the trial-level in randomized clinical trials (RCTs) testing antibody-drugs conjugates (ADC) has never been investigate…
View article: Biologics as well as inhaled anti-asthmatic therapy achieve clinical remission: Evidence from the Severe Asthma Network in Italy (SANI)
Biologics as well as inhaled anti-asthmatic therapy achieve clinical remission: Evidence from the Severe Asthma Network in Italy (SANI) Open
View article: Gastric neuroendocrine tumors: 20‐Year experience in a reference center
Gastric neuroendocrine tumors: 20‐Year experience in a reference center Open
Few studies have been published on the long‐term outcomes of patients with gastric neuroendocrine tumors (gNETs). We analyzed their management over a two‐decade period, focusing on endoscopic and clinical outcomes. Clinical, laboratory, en…
View article: Outcomes of patients with advanced solid tumors who discontinued immune-checkpoint inhibitors: a systematic review and meta-analysis
Outcomes of patients with advanced solid tumors who discontinued immune-checkpoint inhibitors: a systematic review and meta-analysis Open
View article: Questionnaires May Help Pulmonologists for Referral of Patients With IPF to a Holistic Approach
Questionnaires May Help Pulmonologists for Referral of Patients With IPF to a Holistic Approach Open
View article: Analysis of a Large Severe Acute Respiratory Syndrome Coronavirus 2 (Alpha) Outbreak in a Catalan Prison Using Conventional and Genomic Epidemiology
Analysis of a Large Severe Acute Respiratory Syndrome Coronavirus 2 (Alpha) Outbreak in a Catalan Prison Using Conventional and Genomic Epidemiology Open
Enforcing strict protocols that prevent transmission of airborne infections in prisons is challenging. We examine a large severe acute respiratory syndrome coronavirus 2 outbreak in a Catalan penitentiary center in February–April 2021, pri…
View article: Surrogate endpoints for overall survival in randomized clinical trials testing immune checkpoint inhibitors: a systematic review and meta-analysis
Surrogate endpoints for overall survival in randomized clinical trials testing immune checkpoint inhibitors: a systematic review and meta-analysis Open
Introduction There is debate on which are the best surrogate endpoint and metric to capture treatment effect on overall survival (OS) in RCTs testing immune-checkpoint inhibitors (ICIs). Methods We systematically searched for RCTs testing …
View article: “Heterogeneity of treatment effect on patients’ long-term outcome according to pathological response type in neoadjuvant RCTs for breast cancer.”
“Heterogeneity of treatment effect on patients’ long-term outcome according to pathological response type in neoadjuvant RCTs for breast cancer.” Open
View article: Tailoring the optimal duration of the extended adjuvant endocrine therapy in patients with early-stage breast cancer. A systematic review and meta-analysis of randomized clinical trials
Tailoring the optimal duration of the extended adjuvant endocrine therapy in patients with early-stage breast cancer. A systematic review and meta-analysis of randomized clinical trials Open
View article: SARS-CoV-2 Infection in San Patrignano, the Largest European Drug Rehabilitation Community
SARS-CoV-2 Infection in San Patrignano, the Largest European Drug Rehabilitation Community Open
Background: Studies on SARS-CoV-2 conducted in confined settings for prolonged times allow researchers to assess how the coronavirus spreads. San Patrignano (SP), Italy, is the largest European drug rehabilitation facility. Methods: Betwee…
View article: Association of Anticancer Immune Checkpoint Inhibitors With Patient-Reported Outcomes Assessed in Randomized Clinical Trials
Association of Anticancer Immune Checkpoint Inhibitors With Patient-Reported Outcomes Assessed in Randomized Clinical Trials Open
Importance The association of immune checkpoint inhibitors (ICIs) with patient quality of life has been poorly explored. Objective To evaluate patient-reported outcomes (PROs) assessed in randomized clinical trials (RCTs) of immunotherapy-…
View article: Sodium nitroprusside in acute heart failure: A multicenter historic cohort study
Sodium nitroprusside in acute heart failure: A multicenter historic cohort study Open
View article: Sodium Nitroprusside in Acute Heart Failure: A Multicenter Historic Cohort Study
Sodium Nitroprusside in Acute Heart Failure: A Multicenter Historic Cohort Study Open
View article: Characteristics and Clinical Implications of Carbapenemase-Producing <i>Klebsiella pneumoniae</i> Colonization and Infection, Italy
Characteristics and Clinical Implications of Carbapenemase-Producing <i>Klebsiella pneumoniae</i> Colonization and Infection, Italy Open
Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp) has been endemic in Italy since 2013. In a multicenter cohort study, we investigated various aspects of KPC-Kp among patients, including 15-day mortality rates and delays…