Isabella W. Martin
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View article: Variants of β-lactamase-encoding genes are disseminated by multiple genetically distinct lineages of bloodstream Escherichia coli
Variants of β-lactamase-encoding genes are disseminated by multiple genetically distinct lineages of bloodstream Escherichia coli Open
Multiple but genetically distinct E. coli lineages similarly cause BSI and shape AMR dissemination, emphasizing the opportunistic nature of E. coli in invasive infections.
View article: Activity of novel ceftibuten-avibactam, ceftazidime-avibactam, and comparators against a challenge set of <i>Enterobacterales</i> from outpatient centers and nursing homes across the United States (2022–2024)
Activity of novel ceftibuten-avibactam, ceftazidime-avibactam, and comparators against a challenge set of <i>Enterobacterales</i> from outpatient centers and nursing homes across the United States (2022–2024) Open
Ceftibuten is being developed in combination with the oral prodrug of avibactam. Outpatient isolates ( n = 500) from 11 US states underwent susceptibility testing with manual broth microdilution. Ceftibuten had susceptibility rates of 64% …
View article: Simplifying SARS-CoV-2 wastewater-based surveillance using an automated FDA EUA assay
Simplifying SARS-CoV-2 wastewater-based surveillance using an automated FDA EUA assay Open
Wastewater-based surveillance (WBS) can track the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in communities. Laboratory methods for this testing involve labor-intensive, multi-step processes. This study assessed…
View article: A novel framework for the automated characterization of Gram-stained blood culture slides using a large-scale vision transformer
A novel framework for the automated characterization of Gram-stained blood culture slides using a large-scale vision transformer Open
This study introduces a new framework for the artificial intelligence-based characterization of Gram-stained whole-slide images (WSIs). As a test for the diagnosis of bloodstream infections, Gram stains provide critical early data to infor…
View article: P-1067. <i>In Vitro</i> Potency of Ceftibuten-Avibactam (CTB-AVI) and Comparators against Extended-Spectrum Beta-Lactamase (ESBL)-like Enterobacterales from Outpatient Centers and Nursing Homes in the United States
P-1067. <i>In Vitro</i> Potency of Ceftibuten-Avibactam (CTB-AVI) and Comparators against Extended-Spectrum Beta-Lactamase (ESBL)-like Enterobacterales from Outpatient Centers and Nursing Homes in the United States Open
Background CTB is a currently available oral third-generation cephalosporin that is being developed in combination with the oral prodrug of AVI. In this study, we evaluated the in vitro activity of CTB-AVI against clinical ESBL-like Entero…
View article: P-836. Non-Beta Lactam Agents for Definitive Treatment of Ampicillin-Susceptible <i>Enterococcus</i> Bacteremia: A Single Center Experience
P-836. Non-Beta Lactam Agents for Definitive Treatment of Ampicillin-Susceptible <i>Enterococcus</i> Bacteremia: A Single Center Experience Open
Background Enterococcus bacteremia (EB) is a serious infection with high morbidity and mortality. While anti-enterococcal beta-lactams (BL) remain the mainstay of therapy against ampicillin-susceptible (AS) EB, non-beta-lactam (NBL) antimi…
View article: Non-beta-lactam agents for definitive treatment of ampicillin-susceptible <i>Enterococcus</i> bacteremia: a single-center experience
Non-beta-lactam agents for definitive treatment of ampicillin-susceptible <i>Enterococcus</i> bacteremia: a single-center experience Open
Objective: To describe the use of non-beta-lactam agents (NBL) to treat ampicillin-susceptible Enterococcus bacteremia (ASEB), and to identify factors associated with their use. Methods: A single-center retrospective study at a rural terti…
View article: A Novel Framework for the Automated Characterization of Gram-Stained Blood Culture Slides Using a Large-Scale Vision Transformer
A Novel Framework for the Automated Characterization of Gram-Stained Blood Culture Slides Using a Large-Scale Vision Transformer Open
This study introduces a new framework for the artificial intelligence-assisted characterization of Gram-stained whole-slide images (WSIs). As a test for the diagnosis of bloodstream infections, Gram stains provide critical early data to in…
View article: Analytical validation of a semi-automated methodology for quantitative measurement of SARS-CoV-2 RNA in wastewater collected in northern New England
Analytical validation of a semi-automated methodology for quantitative measurement of SARS-CoV-2 RNA in wastewater collected in northern New England Open
Wastewater - based epidemiology (WBE) can be used to monitor the community presence of infectious disease pathogens of public health concern such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Viral nucleic acid has b…
View article: Reply to Kidd et al., “Inconsistencies within the proposed framework for stabilizing fungal nomenclature risk further confusion”
Reply to Kidd et al., “Inconsistencies within the proposed framework for stabilizing fungal nomenclature risk further confusion” Open
International audience
View article: 1225. Optimization of Antimicrobial Therapy for Extended-Spectrum β-Lactamase-Producing <i>Enterobacterales</i> (ESBL-E) Bloodstream Infections Through Laboratory-Based Interventions
1225. Optimization of Antimicrobial Therapy for Extended-Spectrum β-Lactamase-Producing <i>Enterobacterales</i> (ESBL-E) Bloodstream Infections Through Laboratory-Based Interventions Open
Background In 2020, the Infectious Diseases Society of America (IDSA) published clinical practice guidance recommending up-front treatment with an IV carbapenem for severe infections with extended-spectrum β-lactamase (ESBL)-producing Ente…
View article: A conceptual framework for nomenclatural stability and validity of medically important fungi: a proposed global consensus guideline for fungal name changes supported by ABP, ASM, CLSI, ECMM, ESCMID-EFISG, EUCAST-AFST, FDLC, IDSA, ISHAM, MMSA, and MSGERC
A conceptual framework for nomenclatural stability and validity of medically important fungi: a proposed global consensus guideline for fungal name changes supported by ABP, ASM, CLSI, ECMM, ESCMID-EFISG, EUCAST-AFST, FDLC, IDSA, ISHAM, MMSA, and MSGERC Open
The rapid pace of name changes of medically important fungi is creating challenges for clinical laboratories and clinicians involved in patient care. We describe two sources of name change which have different drivers, at the species versu…
View article: Phylogenetic lineages and antimicrobial resistance determinants of clinical <i>Klebsiella oxytoca</i> spanning local to global scales
Phylogenetic lineages and antimicrobial resistance determinants of clinical <i>Klebsiella oxytoca</i> spanning local to global scales Open
Klebsiella oxytoca is an opportunistic pathogen causing serious nosocomial infections. Knowledge about the population structure and diversity of healthcare-associated K. oxytoca from a genomic standpoint remains limited. Here, we character…
View article: Cystic Echinococcosis in Northern New Hampshire, USA
Cystic Echinococcosis in Northern New Hampshire, USA Open
In April 2022 and December 2022, the New Hampshire Department of Health and Human Services confirmed 2 cases of locally acquired human pulmonary cystic echinococcosis caused by Echinococcus granulosus tapeworms. Both patients reported dres…
View article: An unusual presentation of a rare disease: acute upper limb ischemia as the presenting symptom of Whipple’s Endocarditis, a case report
An unusual presentation of a rare disease: acute upper limb ischemia as the presenting symptom of Whipple’s Endocarditis, a case report Open
Background Whipple's disease is known to cause multiple varied systemic symptoms, and is a well-documented cause of culture-negative endocarditis. Endocarditis secondary to Whipple disease, however, has rarely been known to present primari…
View article: Additional file 1 of Multi-host infection and phylogenetically diverse lineages shape the recombination and gene pool dynamics of Staphylococcus aureus
Additional file 1 of Multi-host infection and phylogenetically diverse lineages shape the recombination and gene pool dynamics of Staphylococcus aureus Open
Additional file 1: Supplementary Table S1. Accession numbers, associated metadata, ST, BAPS sequence cluster, homologous recombination information, AMR and virulence genes and rep families of the 437 S. aureus genomes in this study. Supple…
View article: Prophage-encoded immune evasion factors are critical for Staphylococcus aureus host infection, switching, and adaptation
Prophage-encoded immune evasion factors are critical for Staphylococcus aureus host infection, switching, and adaptation Open
Staphylococcus aureus is a multi-host pathogen that causes infections in animals and humans globally. The specific genetic loci-and the extent to which they drive cross-species switching, transmissibility, and adaptation-are not well under…
View article: Answer to August 2022 Photo Quiz
Answer to August 2022 Photo Quiz Open
Read the full article for the answer.
View article: Photo Quiz: 83-Year-Old with Progressive Slurred Speech and Right-Sided Weakness
Photo Quiz: 83-Year-Old with Progressive Slurred Speech and Right-Sided Weakness Open
An 83-year-old woman with a history of non-central nervous system lymphoma presented to our hospital with a 2-week history of progressively slurred speech and 3 days of new-onset right-sided weakness. She had been diagnosed with malignant …
View article: Genome Evolution of Invasive Methicillin-Resistant Staphylococcus aureus in the Americas
Genome Evolution of Invasive Methicillin-Resistant Staphylococcus aureus in the Americas Open
Bloodstream infections due to S. aureus cause significant patient morbidity and mortality worldwide, exacerbated by the emergence and spread of methicillin resistant S. aureus (MRSA). This study provides important insights on the evolution…
View article: Wastewater-Based SARS-CoV-2 Surveillance in Northern New England
Wastewater-Based SARS-CoV-2 Surveillance in Northern New England Open
Despite vaccination efforts, the delta and omicron variants of SARS-CoV-2 have caused global surges of COVID-19. As the COVID-19 pandemic continues, it is important to find new ways of tracking early signs of SARS-CoV-2 outbreaks.
View article: Application of Standardized Residual Component Culture Criteria for Suspected Septic Transfusion Reactions Would Increase the Component Culturing Rate at a Single Academic Medical Center
Application of Standardized Residual Component Culture Criteria for Suspected Septic Transfusion Reactions Would Increase the Component Culturing Rate at a Single Academic Medical Center Open
Objectives The 2019 SCARED study developed the Biomedical Excellence for Safer Transfusion (BEST) criteria in an effort to standardize the decision to culture residual units in the context of suspected septic transfusion reactions (STRs). …
View article: Raising the Bar: Improving Antimicrobial Resistance Detection by Clinical Laboratories by Ensuring Use of Current Breakpoints
Raising the Bar: Improving Antimicrobial Resistance Detection by Clinical Laboratories by Ensuring Use of Current Breakpoints Open
Background Antimicrobial resistance (AMR) is a pressing global challenge detected by antimicrobial susceptibility testing (AST) performed by clinical laboratories. AST results are interpreted using clinical breakpoints, which are updated t…
View article: Considerations from the College of American Pathologists for Implementation of an Assay for SARS-CoV-2 Testing after a Change in Regulatory Status
Considerations from the College of American Pathologists for Implementation of an Assay for SARS-CoV-2 Testing after a Change in Regulatory Status Open
The U.S. Food & Drug Administration (FDA) regulates the marketing of manufacturers’ in vitro diagnostic tests (IVDs), including assays for the detection of SARS-CoV-2.