Isabelle Couillin
YOU?
Author Swipe
View article: Lymphopenia drives T cell exhaustion in immunodeficient STING gain-of-function mice
Lymphopenia drives T cell exhaustion in immunodeficient STING gain-of-function mice Open
STING gain-of-function (GOF) mutations cause STING-Associated Vasculopathy with onset in Infancy (SAVI), a severe autoinflammatory disease. Mice carrying STING GOF V154M mutation develop profound T cell lymphopenia, partly due to impaired …
View article: Ozone-induced lung injury and inflammation: Pathways and therapeutic targets for pulmonary diseases caused by air pollutants
Ozone-induced lung injury and inflammation: Pathways and therapeutic targets for pulmonary diseases caused by air pollutants Open
Exposure to ambient Ozone (O3) air pollution directly causes by its oxidative properties, respiratory epithelial cell injury, and cell death, which promote inflammation and hyperreactivity, posing a significant public health con…
View article: Gasdermins induce the release of mitochondrial DNA during pyroptosis and apoptosis
Gasdermins induce the release of mitochondrial DNA during pyroptosis and apoptosis Open
Pyroptosis and intrinsic apoptosis are two forms of regulated cell death driven by active caspases where plasma membrane permeabilization is induced by gasdermin pores. Caspase-1 induces gasdermin D pore formation during pyroptosis meanwhi…
View article: Lymphopenia drives T cell exhaustion in immunodeficient STING gain-of-function mice
Lymphopenia drives T cell exhaustion in immunodeficient STING gain-of-function mice Open
STING gain-of-function (GOF) mutations are associated with the severe autoinflammatory disease designated STING Associated Vasculopathy with onset in Infancy (SAVI). Mice with the STING GOF V154M mutation develop profound T cell lymphopeni…
View article: NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype
NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype Open
Background Senescence is a cellular aging-related process triggered by different stresses and characterized by the secretion of various inflammatory factors referred to as senescence-associated secretory phenotype (SASP), some of which are…
View article: NLRP6 controls pulmonary inflammation from cigarette smoke in a gut microbiota-dependent manner
NLRP6 controls pulmonary inflammation from cigarette smoke in a gut microbiota-dependent manner Open
Chronic obstructive pulmonary disease (COPD) is a major health issue primarily caused by cigarette smoke (CS) and characterized by breathlessness and repeated airway inflammation. NLRP6 is a cytosolic innate receptor controlling intestinal…
View article: Lung inflammation and interstitial fibrosis by targeted alveolar epithelial type I cell death
Lung inflammation and interstitial fibrosis by targeted alveolar epithelial type I cell death Open
Introduction The pathogenesis of chronic lung diseases is multifaceted with a major role of recurrent micro-injuries of the epithelium. While several reports clearly indicated a prominent role for surfactant-producing alveolar epithelial t…
View article: Pannexin 1 activity in astroglia sets hippocampal neuronal network patterns
Pannexin 1 activity in astroglia sets hippocampal neuronal network patterns Open
Astroglial release of molecules is thought to actively modulate neuronal activity, but the nature, release pathway, and cellular targets of these neuroactive molecules are still unclear. Pannexin 1, expressed by neurons and astrocytes, for…
View article: STING Targeting in Lung Diseases
STING Targeting in Lung Diseases Open
The cGAS–STING pathway displays important functions in the regulation of innate and adaptive immunity following the detection of microbial and host-derived DNA. Here, we briefly summarize biological functions of STING and review recent lit…
View article: Cigarette smoke-induced gasdermin D activation in bronchoalveolar macrophages and bronchial epithelial cells dependently on NLRP3
Cigarette smoke-induced gasdermin D activation in bronchoalveolar macrophages and bronchial epithelial cells dependently on NLRP3 Open
Chronic pulmonary inflammation and chronic obstructive pulmonary disease (COPD) are major health issues largely due to air pollution and cigarette smoke (CS) exposure. The role of the innate receptor NLRP3 (nucleotide-binding domain and le…
View article: STING Signaling and Sterile Inflammation
STING Signaling and Sterile Inflammation Open
Innate immunity is regulated by a broad set of evolutionary conserved receptors to finely probe the local environment and maintain host integrity. Besides pathogen recognition through conserved motifs, several of these receptors also sense…
View article: Gasdermins mediate cellular release of mitochondrial DNA during pyroptosis and apoptosis
Gasdermins mediate cellular release of mitochondrial DNA during pyroptosis and apoptosis Open
Pyroptosis and intrinsic apoptosis are two forms of regulated cell death driven by active caspases where plasma membrane permeabilization is induced by gasdermin pores. Caspase‐1 induces gasdermin D pore formation during pyroptosis, wherea…
View article: Chronic <i>Pseudomonas aeruginosa</i> Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling
Chronic <i>Pseudomonas aeruginosa</i> Lung Infection Is IL-1R Independent, but Relies on MyD88 Signaling Open
Cystic fibrosis is associated with chronic Pseudomonas aeruginosa colonization and inflammation. The role of MyD88, the shared adapter protein of the proinflammatory TLR and IL-1R families, in chronic P. aeruginosa biofilm lung infection i…
View article: Protective Role of the Nucleic Acid Sensor STING in Pulmonary Fibrosis
Protective Role of the Nucleic Acid Sensor STING in Pulmonary Fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is the most common and severe type of interstitial lung disease for which current treatments display limited efficacy. IPF is largely driven by host-derived danger signals released upon recurrent local t…
View article: Author Correction: Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization
Author Correction: Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization Open
View article: Corrigendum: Blockade of IL-33R/ST2 Signaling Attenuates Toxoplasma gondii Ileitis Depending on IL-22 Expression
Corrigendum: Blockade of IL-33R/ST2 Signaling Attenuates Toxoplasma gondii Ileitis Depending on IL-22 Expression Open
[This corrects the article DOI: 10.3389/fimmu.2019.00702.].
View article: Molecular basis of carrageenan-induced cytokines production in macrophages
Molecular basis of carrageenan-induced cytokines production in macrophages Open
View article: P2X7 Receptor Promotes Mouse Mammary Cancer Cell Invasiveness and Tumour Progression, and Is a Target for Anticancer Treatment
P2X7 Receptor Promotes Mouse Mammary Cancer Cell Invasiveness and Tumour Progression, and Is a Target for Anticancer Treatment Open
The P2X7 receptor is an ATP-gated cation channel with a still ambiguous role in cancer progression, proposed to be either pro- or anti-cancerous, depending on the cancer or cell type in the tumour. Its role in mammary cancer progression is…
View article: B-Cell Activating Factor Secreted by Neutrophils Is a Critical Player in Lung Inflammation to Cigarette Smoke Exposure
B-Cell Activating Factor Secreted by Neutrophils Is a Critical Player in Lung Inflammation to Cigarette Smoke Exposure Open
Cigarette smoke (CS) is the major cause of chronic lung injuries, such as chronic obstructive pulmonary disease (COPD). In patients with severe COPD, tertiary lymphoid follicles containing B lymphocytes and B cell-activating factor (BAFF) …
View article: IL-17 suppresses the therapeutic activity of cancer vaccines through the inhibition of CD8 <sup>+</sup> T-cell responses
IL-17 suppresses the therapeutic activity of cancer vaccines through the inhibition of CD8 <sup>+</sup> T-cell responses Open
Antitumor immunity is mediated by Th1 CD4+ and CD8+ T lymphocytes, which induce tumor-specific cytolysis, whereas Th17 CD4+ T cells have been described to promote tumor growth. Here, we explored the influen…
View article: Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice
Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice Open
View article: Blockade of IL-33R/ST2 Signaling Attenuates Toxoplasma gondii Ileitis Depending on IL-22 Expression
Blockade of IL-33R/ST2 Signaling Attenuates Toxoplasma gondii Ileitis Depending on IL-22 Expression Open
Oral T. gondii infection (30 cysts of 76K strain) induces acute lethal ileitis in sensitive C57BL/6 (B6) mice with increased expression of IL-33 and its receptor ST2 in the ileum. Here we show that IL-33 is involved in ileitis, sinc…
View article: Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization
Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization Open
View article: Carrageenan Triggers NLRP3 Inflammasome Activation and IL-1β Production by Macrophages
Carrageenan Triggers NLRP3 Inflammasome Activation and IL-1β Production by Macrophages Open
View article: The IL-33 Receptor ST2 Regulates Pulmonary Inflammation and Fibrosis to Bleomycin
The IL-33 Receptor ST2 Regulates Pulmonary Inflammation and Fibrosis to Bleomycin Open
Idiopathic pulmonary fibrosis is a progressive, devastating, and yet untreatable fibrotic disease of unknown origin. Interleukin-33 (IL-33), an IL-1 family member acts as an alarmin with pro-inflammatory properties when released after stre…
View article: Inflammation drives nitric oxide synthase 2 expression by γδ T cells and affects the balance between melanoma and vitiligo associated melanoma
Inflammation drives nitric oxide synthase 2 expression by γδ T cells and affects the balance between melanoma and vitiligo associated melanoma Open
The high expression of inducible nitric oxide synthase (NOS2) by myeloid-derived suppressor cells (MDSCs) is a key mechanism of immune evasion in cancer. Recently we reported that NOS2 is also expressed by γδ T cells in melanoma, contribut…
View article: Discordance in cathepsin B and cystatin C expressions in bronchoalveolar fluids between murine bleomycin-induced fibrosis and human idiopathic fibrosis
Discordance in cathepsin B and cystatin C expressions in bronchoalveolar fluids between murine bleomycin-induced fibrosis and human idiopathic fibrosis Open
The activity of cysteine cathepsin B increased markedly in lung homogenates and in bronchoalveolar lavage fluids (BALF) of the mouse model of bleomycin-induced lung fibrosis after 14 days of challenge. In contrast the level of the cysteine…
View article: Role of interleukin-1 receptor 1/MyD88 signalling in the development and progression of pulmonary hypertension
Role of interleukin-1 receptor 1/MyD88 signalling in the development and progression of pulmonary hypertension Open
Pulmonary artery smooth muscle cell (PA-SMC) proliferation and inflammation are key components of pulmonary arterial hypertension (PAH). Interleukin (IL)-1β binds to IL-1 receptor (R)1, thereby recruiting the molecular adaptor myeloid diff…
View article: The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine
The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine Open