Explanipedia

Enhancement of In Vivo Bone Regeneration by the Carbohydrate Derivative DP2 Open

Nissrine Ballout, Sylvestre Toumieux, Walaa Darwiche, Cathy Gomila, E. Trécherel , et al. · 2025

Background/Objectives: Delays in bone healing and complications of remodeling constitute a major medical problem—particularly in older adults and patients with comorbidities. Current therapeutic approaches are based on strategies that prom…

From Classical to Alternative Pathways of 2-Arachidonoylglycerol Synthesis: AlterAGs at the Crossroad of Endocannabinoid and Lysophospholipid Signaling Open

Fabienne Briand‐Mésange, Isabelle Gennero, Juliette Salles, Stéphanie Trudel, Lionel Dahan , et al. · 2024

2-arachidonoylglycerol (2-AG) is the most abundant endocannabinoid (EC), acting as a full agonist at both CB1 and CB2 cannabinoid receptors. It is synthesized on demand in postsynaptic membranes through the sequential action of phosphoinos…

Differential DNA methylation in iPSC-derived dopaminergic neurons: a step forward on the role of SNORD116 microdeletion in the pathophysiology of addictive behavior in Prader-Willi syndrome Open

Juliette Salles, Sanaa Eddiry, Saber Amri, Mélissa Galindo, Emmanuelle Lacassagne , et al. · 2024

DP2, a Carbohydrate Derivative, Enhances In Vitro Osteoblast Mineralisation Open

Nissrine Ballout, Agnès Boullier, Walaa Darwiche, Katia Aït-Mohand, E. Trécherel , et al. · 2023

Bone fracture healing is a complex biological process involving four phases coordinated over time: hematoma formation, granulation tissue formation, bony callus formation, and bone remodelling. Bone fractures represent a significant health…

Vitamin D and calcium intakes in general pediatric populations: A French expert consensus paper Open

Justine Bacchetta, Thomas Édouard, Gilles Laverny, Julie Bernardor, Aurélia Bertholet‐Thomas , et al. · 2022

This consensus document was developed to provide guidance to health care professionals on the use of nutritional vitamin D and dietary modalities to achieve the recommended calcium intakes in general pediatric populations. These CPPs will …

Diagnostic yield of bone fragility gene panel sequencing in children and young adults referred for idiopathic primary osteoporosis at a single regional reference centre Open

Coline Rouleau, Margaux Malorie, Corinne Collet, Valérie Porquet‐Bordes, Isabelle Gennero , et al. · 2022

Is ghrelin a biomarker of early-onset scoliosis in children with Prader–Willi syndrome? Open

Dibia Liz Pacoricona Alfaro, Gwénaëlle Diene, Graziella Pinto, Jean‐Pierre Salles, Isabelle Gennero , et al. · 2021

SNORD116 and growth hormone therapy impact IGFBP7 in Prader–Willi syndrome Open

Sanaa Eddiry, Gwénaëlle Diene, Catherine Molinas, Juliette Salles, Françoise Auriol , et al. · 2021

Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity Open

Patrick Ostkamp, Anke Salmen, Béatrice Pignolet, Dennis Görlich, Till F. M. Andlauer , et al. · 2020

Significance Low sunlight exposure and low vitamin D (vitD) levels are risk factors for the development of multiple sclerosis. However, there is still an ongoing debate, whether sunlight and vitD also modulate disease severity and worsenin…

The type 1 lysophosphatidic acid receptor is involved in osteoblastogenesis up to osteocytogenesis Open

Adebayo Candide Alioli, Léa Demesmay, Sara Laurencin‐Dalicieux, Nicolas Beton, Delphine Farlay , et al. · 2020

International audience

Ghrelin uses the GHS-R1a/Gi/cAMP pathway and induces differentiation only in mature osteoblasts. This ghrelin pathway is impaired in AIS patients Open

Ronan Barré, Nicolas Beton, Aurélie Batut, Frank Accabled, Jérôme Sales de Gauzy , et al. · 2020

Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity Open

Patrick Ostkamp, Anke Salmen, Béatrice Pignolet, Dennis Görlich, Till F. M. Andlauer , et al. · 2020

Background Multiple sclerosis (MS) disease risk is associated with reduced sun exposure. This study assessed the relationship between measures of sun-exposure (vitamin D (vitD), latitude) and MS disease severity, the mechanisms of action, …

HIV-1-Infected Human Macrophages, by Secreting RANK-L, Contribute to Enhanced Osteoclast Recruitment Open

Rémi Mascarau, Florent Bertrand, Arnaud Labrousse, Isabelle Gennero, Renaud Poincloux , et al. · 2020

HIV-1 infection is frequently associated with low bone density, which can progress to osteoporosis leading to a high risk of fractures. Only a few mechanisms have been proposed to explain the enhanced osteolysis in the context of HIV-1 inf…

Expression of the type 1 lysophosphatidic acid receptor in osteoblastic cell lineage controls both bone mineralization and osteocyte specification Open

Candide Alioli, Léa Demesmay, Sara Laurencin‐Dalicieux, Nicolas Beton, Delphine Farlay , et al. · 2020

HIV-1-infected human macrophages, by secreting RANKL, contribute to enhanced osteoclastogenesis Open

Rémi Mascarau, Florent Bertrand, Arnaud Labrousse, Isabelle Gennero, Renaud Poincloux , et al. · 2020

HIV-1 infection is frequently associated with low bone density, which can progress to osteoporosis leading to a high risk of fractures. Only a few mechanisms have been proposed to explain the enhanced osteolysis in the context of HIV-1 inf…

P5389Big data and severe hypertriglyceridemia: prevalence in 297 909 individuals Open

Jean Ferrières, Marie-Sophie Combis, Céline Verdier, Annelise Genoux, Isabelle Gennero , et al. · 2018

Cross-sectional associations of plasma vitamin D with cerebral β-amyloid in older adults at risk of dementia Open

Fati Nourhashémi, Claudie Hooper, Christelle Cantet, Catherine Féart, Isabelle Gennero , et al. · 2018

Early postnatal soluble FGFR3 therapy prevents the atypical development of obesity in achondroplasia Open

Céline Saint-Laurent, Stephanie García, Vincent Sarrazy, Karine Dumas, Florence Authier , et al. · 2018

This study demonstrate that achondroplasia patients develop an atypical obesity with preferential abdominal obesity not associated with classical complications. These results suggest that achondroplasia induces an uncommon metabolism of en…

Noonan syndrome-causing SHP2 mutants impair ERK-dependent chondrocyte differentiation during endochondral bone growth Open

Mylène Tajan, Julie Pernin-Grandjean, Nicolas Beton, Isabelle Gennero, Florence Capilla , et al. · 2018

Growth retardation is a constant feature of Noonan syndrome (NS) but its physiopathology remains poorly understood. We previously reported that hyperactive NS-causing SHP2 mutants impair the systemic production of insulin-like growth facto…

Bone degradation machinery of osteoclasts: An HIV-1 target that contributes to bone loss Open

Brigitte Raynaud‐Messina, Lucie Bracq, Maeva Dupont, Shanti Souriant, Shariq M. Usmani , et al. · 2018

Significance Bone deficits are frequent complications observed in HIV-1–infected patients. Our study demonstrates that HIV-1 infects osteoclasts, the cells specialized in bone degradation, using different models including HIV-1–infected hu…

Fasting total ghrelin levels are increased in patients with adolescent idiopathic scoliosis Open

Jérôme Sales de Gauzy, Isabelle Gennero, Olivier Delrous, Jean‐Pierre Salles, Benoît Lepage , et al. · 2015

Muscle and Bone Impairment in Children With Marfan Syndrome: Correlation With Age and <i>FBN1</i> Genotype Open

Elsa Haine, Jean‐Pierre Salles, Philippe Khau Van Kien, F. Conte-Auriol, Isabelle Gennero , et al. · 2015

Marfan syndrome (MFS) is a rare connective tissue disorder caused by mutation in the gene encoding the extracellular matrix protein fibrillin-1 (FBN1), leading to transforming growth factor-beta (TGF-β) signaling dysregulation. Although de…

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