Isabelle K. Vila
YOU?
Author Swipe
View article: The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling
The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling Open
The detection of cytosolic dsDNA is tightly regulated to avoid pathological inflammatory responses. A major pathway involved in their detection relies on the cyclic GMP-AMP synthase (cGAS) that triggers activation of the Stimulator of inte…
View article: DNA-PK controls cyclic dinucleotide-associated type I Interferon responses
DNA-PK controls cyclic dinucleotide-associated type I Interferon responses Open
Summary Cytosolic dsDNAs are potent immune-stimulatory molecules that trigger inflammation in several human pathologies 1,2 . A major pathway for the detection of cytosolic dsDNA relies on the cyclic GMP-AMP (cGAMP) synthase (cGAS) that pr…
View article: Multiplexed targeted analysis of polyunsaturated fatty acids and oxylipins using liquid chromatography-tandem mass spectrometry
Multiplexed targeted analysis of polyunsaturated fatty acids and oxylipins using liquid chromatography-tandem mass spectrometry Open
Polyunsaturated fatty acids (PUFAs) and their oxidized products (oxylipins) are important mediators in intra- and extra-cellular signaling. We describe here the simultaneous quantification of 163 PUFAs and oxylipins using liquid chromatogr…
View article: Harnessing the cooperation between DNA‐PK and cGAS in cancer therapies
Harnessing the cooperation between DNA‐PK and cGAS in cancer therapies Open
The cyclic GMP‐AMP synthase–stimulator of interferon genes (cGAS‐STING) pathway is central for the initiation of anti‐tumoural immune responses. Enormous effort has been made to optimise the design and administration of STING agonists to s…
View article: The unexpected role of the STING protein in lipid metabolism
The unexpected role of the STING protein in lipid metabolism Open
Detection of cytosolic pathological nucleic acids is a key step for the initiation of innate immune responses. In the past decade, the stimulator of interferon genes (STING) adaptor protein has emerged as a central platform enabling the ac…
View article: The crosstalk between DNA-PK and cGAS drives tumor immunogenicity
The crosstalk between DNA-PK and cGAS drives tumor immunogenicity Open
SUMMARY Cytosolic DNAs promote inflammatory responses upon detection by the cyclic GMP-AMP (cGAMP) synthase (cGAS). It has been thus suggested that cGAS downregulation is an immune escape strategy harnessed by tumor cells. Here, we used gl…
View article: IP STING - Identification of new partners
IP STING - Identification of new partners Open
To access STING function in absence of inflammation, given the tight interconnexion between metabolic and immune pathways, we questioned the impact of Sting ablation on metabolic parameters in vivo. Mice deficient for STING presented profo…
View article: Nucleic Acid Immunity and DNA Damage Response: New Friends and Old Foes
Nucleic Acid Immunity and DNA Damage Response: New Friends and Old Foes Open
The maintenance of genomic stability in multicellular organisms relies on the DNA damage response (DDR). The DDR encompasses several interconnected pathways that cooperate to ensure the repair of genomic lesions. Besides their repair funct…
View article: Sting orchestrates the crosstalk between polyunsaturated fatty acids metabolism and inflammatory responses
Sting orchestrates the crosstalk between polyunsaturated fatty acids metabolism and inflammatory responses Open
Summary Inflammatory disorders are major health issues in which immune function and metabolic homeostasis are concertedly altered. Yet, the molecular mechanisms coordinating innate and metabolic pathways in homeostatic conditions are poorl…
View article: Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation
Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation Open
The LysRS-Ap 4 A axis impairs cGAS-STING pathway activation, delaying nucleic acid-driven innate immune responses.
View article: A muscle-specific UBE2O/AMPKα2 axis promotes insulin resistance and metabolic syndrome in obesity
A muscle-specific UBE2O/AMPKα2 axis promotes insulin resistance and metabolic syndrome in obesity Open
Ubiquitin-conjugating enzyme E2O (UBE2O) is expressed preferentially in metabolic tissues, but its role in regulating energy homeostasis has yet to be defined. Here we find that UBE2O is markedly upregulated in obese subjects with type 2 d…
View article: A new duet in cancer biology: AMPK the typical and UBE2O the atypical
A new duet in cancer biology: AMPK the typical and UBE2O the atypical Open
Ubiquitin-conjugating enzyme E2O (UBE2O) is upregulated in human cancers. We have demonstrated that genetic deletion or pharmacological blockade of UBE2O reduces tumorigenesis through inhibiting the mammalian target of rapamycin complex 1-…
View article: Exercise-like effects by Estrogen-related receptor-gamma in muscle do not prevent insulin resistance in db/db mice
Exercise-like effects by Estrogen-related receptor-gamma in muscle do not prevent insulin resistance in db/db mice Open
Dissecting exercise-mimicking pathways that can replicate the benefits of exercise in obesity and diabetes may lead to promising treatments for metabolic disorders. Muscle estrogen-related receptor gamma (ERRγ) is induced by exercise, and …