Explanipedia

Mental and Physical Health in Wilson Disease Patients With SARS‐CoV‐2 Infection and Relevance of Long‐COVID Open

Isabelle Mohr, Martin Brand, Christophe Weber, Andrea Langel, Jessica Langel , et al. · 2025

SARS‐CoV‐2 infection and Long COVID (LC) might lead to a significant deterioration of physical and mental health. Wilson disease (WD) patients have a chronic liver and/or neuropsychiatric disease, making it particularly interesting to inve…

Prospective Study to Assess Long‐Term Outcomes of Chelator‐Based Treatment With Trientine Dihydrochloride in Patients With Wilson Disease Open

Isabelle Mohr, Carlot Kruse, Verena Aliane, Karl Heinz Weiss · 2025

Background and Aims Wilson disease is an inherited disorder of copper metabolism affecting mainly the liver and brain. Trientine dihydrochloride (TETA‐2HCl) is approved for the treatment of Wilson disease in patients (≥ 5 years) intolerant…

MMTEB: Massive Multilingual Text Embedding Benchmark Open

Kenneth Enevoldsen, Isaac Chung, Imene Kerboua, Márton Kardos, Ashwin Mathur , et al. · 2025

Text embeddings are typically evaluated on a limited set of tasks, which are constrained by language, domain, and task diversity. To address these limitations and provide a more comprehensive evaluation, we introduce the Massive Multilingu…

A comparative analysis in monitoring 24-hour urinary copper in wilson disease: sampling on or off treatment? Open

Isabelle Mohr, Patrick Lamade, Christophe Weber, Viola Yuriko Leidner, Sebastian Köhrer , et al. · 2025

Fatal Liver Failure After Herpes‐Simplex‐Virus‐2‐Induced Acute Necrotizing Hepatitis: A Case Report Open

Thomas Rösner, Julia Grenz, Marlene Schaumäker, Sven Cuntz, Norbert Blank , et al. · 2025

Herpes simplex virus (HSV) infections are common in the European population, typically presenting with mucocutaneous and anogenital manifestations. However, disseminated infections and organ involvement are rare, usually occurring in immun…

jina-embeddings-v4: Universal Embeddings for Multimodal Multilingual Retrieval Open

Michael Günther, Saba Sturua, Mohammad Kalim Akram, Isabelle Mohr, Alexandru Nicolae Ungureanu , et al. · 2025

jina-clip-v2: Multilingual Multimodal Embeddings for Text and Images Open

Andreas Koukounas, Georgios Mastrapas, Bo Wang, Mohammad Kalim Akram, Sedigheh Eslami , et al. · 2024

Contrastive Language-Image Pretraining (CLIP) has been widely used for crossmodal information retrieval and multimodal understanding tasks. However, CLIP models are mainly optimized for crossmodal vision-language tasks and underperform in …

Clinical experience on switching trientine tetrahydrochloride to trientine dihydrochloride in Wilson disease patients Open

Isabelle Mohr, Timo Schmitt, Christophe Weber, Nicolas Schall, Viola Yuriko Leidner , et al. · 2024

This study evaluates the effectiveness and safety of trientine dihydrochloride (TETA 2‐HCl) in patients with Wilson disease (WD) following a switch from trientine tetrahydrochloride (TETA 4‐HCl). A total of 30 WD patients with stable coppe…

jina-embeddings-v3: Multilingual Embeddings With Task LoRA Open

Saba Sturua, Isabelle Mohr, Mohammad Kalim Akram, Michael Günther, Bo Wang , et al. · 2024

We introduce jina-embeddings-v3, a novel text embedding model with 570 million parameters, achieves state-of-the-art performance on multilingual data and long-context retrieval tasks, supporting context lengths of up to 8192 tokens. The mo…

A comparative analysis in monitoring 24-hour urinary copper in Wilson Disease: Sampling on or off treatment? Open

Isabelle Mohr, Patrick Lamade, Christophe Weber, Viola Yuriko Leidner, Sebastian Köhrer , et al. · 2024

Background:As the concept of empowerment is increasingly adopted across various mental health care contexts, there is a growing need for standardized measures to assess the effectiveness of empowerment approaches. The Empowerment Scale is …

Late Chunking: Contextual Chunk Embeddings Using Long-Context Embedding Models Open

Michael Günther, Isabelle Mohr, Derek Leslie Williams, Bo Wang, Han Xiao · 2024

Many use cases require retrieving smaller portions of text, and dense vector-based retrieval systems often perform better with shorter text segments, as the semantics are less likely to be over-compressed in the embeddings. Consequently, p…

Jina-ColBERT-v2: A General-Purpose Multilingual Late Interaction Retriever Open

Rohan Jha, Bo Wang, Michael Günther, Georgios Mastrapas, Saba Sturua , et al. · 2024

Multi-vector dense models, such as ColBERT, have proven highly effective in information retrieval. ColBERT's late interaction scoring approximates the joint query-document attention seen in cross-encoders while maintaining inference effici…

Jina CLIP: Your CLIP Model Is Also Your Text Retriever Open

Andreas Koukounas, Georgios Mastrapas, Michael Günther, Bo Wang, Scott Martens , et al. · 2024

Contrastive Language-Image Pretraining (CLIP) is widely used to train models to align images and texts in a common embedding space by mapping them to fixed-sized vectors. These models are key to multimodal information retrieval and related…

Author Correction: A fluorometric assay to determine labile copper(II) ions in serum Open

Maria Maares, Alessia Haupt, Christoph Schüßler, Marcel David Kulike-Koczula, Julian Hackler , et al. · 2024

Multi-Task Contrastive Learning for 8192-Token Bilingual Text Embeddings Open

Isabelle Mohr, Markus Krimmel, Saba Sturua, Mohammad Kalim Akram, Andreas Koukounas , et al. · 2024

We introduce a novel suite of state-of-the-art bilingual text embedding models that are designed to support English and another target language. These models are capable of processing lengthy text inputs with up to 8192 tokens, making them…

Jina Embeddings 2: 8192-Token General-Purpose Text Embeddings for Long Documents Open

Michael Günther, Jackmin Ong, Isabelle Mohr, Alaeddine Abdessalem, Tanguy Abel , et al. · 2023

Text embedding models have emerged as powerful tools for transforming sentences into fixed-sized feature vectors that encapsulate semantic information. While these models are essential for tasks like information retrieval, semantic cluster…

Reply to: “Early neurological worsening in Wilson disease: The need for an evidence-based definition” Open

Isabelle Mohr, Aurélia Poujois, Aftab Ala, Karl Heinz Weiss · 2023

Metallothionein: a game changer in histopathological diagnosis of Wilson disease Open

Hendrik Wiethoff, Isabelle Mohr, Alexander Fichtner, Uta Merle, Peter Schirmacher , et al. · 2023

Aims Wilson disease (WD) is a genetic disorder of copper metabolism caused by mutations in the ATP7B gene. Toxic copper accumulation leads to hepatic, neurologic, and psychiatric disorders with variable presentation. Metallothionein (MT) i…

A fluorometric assay to determine labile copper(II) ions in serum Open

Maria Maares, Alessia Haupt, Christoph Schüßler, Marcel David Kulike-Koczula, Julian Hackler , et al. · 2023

Excessive copper impairs intrahepatocyte trafficking and secretion of selenoprotein P Open

Maria Schwarz, C. Meyer, Alina Löser, Kristina Lossow, Julian Hackler , et al. · 2023

Medical care of patients with Wilson disease in Germany: a multidisciplinary survey among university centers Open

Sebastian Zimny, Hélène Bourhis, Sabine Weber, Florian P. Reiter, Simon Hohenester , et al. · 2023

CoVERT: A Corpus of Fact-checked Biomedical COVID-19 Tweets Open

Isabelle Mohr, Amelie Wührl, Roman Klinger · 2022

Over the course of the COVID-19 pandemic, large volumes of biomedical information concerning this new disease have been published on social media. Some of this information can pose a real danger to people's health, particularly when false …

Hepatitis E seroprevalence, cases and management in a large German centre for liver transplantation Open

Shirin Nkongolo, Isabelle Mohr, Jürgen J. Wenzel, Dina Khalid, Markus Mieth , et al. · 2022

Background and Aims Hepatitis E virus (HEV) is an increasingly recognised pathogen in industrialised countries, in particular genotype 3. Patients with underlying liver disease are at increased risk for severe course of the infection. Addi…

Clinical effects and safety of different transarterial chemoembolization methods for bridging and palliative treatments in hepatocellular carcinoma Open

Isabelle Mohr, Marie Vogeler, Jan Pfeiffenberger, Simon David Sprengel, Miriam Klauß , et al. · 2022

Clinical Effects and Safety of Different Transarterial Chemoembolization Methods for Bridging and Palliative Treatments in Hepatocellular Carcinoma Open

Isabelle Mohr, Marie Vogeler, Jan Pfeiffenberger, Simon David Sprengel, Miriam Klauß , et al. · 2021

Purpose: We assessed and compared clinical effects and safety endpoints of three methods of transarterial chemoembolization (TACE), conventional (cTACE), with drug-eluting beads (DEB-TACE), and with degradable starch microspheres (DSM-TACE…

The impact of Wilson disease on myocardial tissue and function: a cardiovascular magnetic resonance study Open

Janek Salatzki, Isabelle Mohr, Jannick Heins, Huseyin Mert Cerci, Andreas Ochs , et al. · 2021

Applicability of scoring systems predicting outcome of transarterial chemoembolization for hepatocellular carcinoma Open

Marie Vogeler, Isabelle Mohr, Jan Pfeiffenberger, Simon David Sprengel, Miriam Klauß , et al. · 2020

Purpose Several scoring systems have been proposed to predict the outcome of transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC). However, the application of these scores to a bridging to transplant setti…

Current anti-copper therapies in management of Wilson disease Open

Isabelle Mohr, Karl Heinz Weiss · 2019

In Wilson disease (WD) severity of disease can vary widely, depending on time of diagnosis. Early treatment can prevent the development of symptoms in patients. In all patients, lifelong medical treatment is indicated. Currently available …

Biochemical markers for the diagnosis and monitoring of Wilson Disease Open

Isabelle Mohr, Karl Weiss · 2019

Wilson disease (WD) is an autosomal recessively-inherited disorder of copper metabolism and characterised by a pathological accumulation of copper. The ATP7B gene encodes for a transmembrane copper transporter essential for biliary copper …

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