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View article: Crystal structures of Mycobacterium tuberculosis and Mycobacterium thermoresistibile glycyl-tRNA synthetases in various liganded states
Crystal structures of Mycobacterium tuberculosis and Mycobacterium thermoresistibile glycyl-tRNA synthetases in various liganded states Open
Glycyl tRNA synthetases (GlyRSs) are prospective drug targets for combating Mycobacterium tuberculosis ( Mtb ) and cancer in humans. These synthetases are of the α2-subtype, with the ortholog in humans being dual targeted to the cytosol an…
View article: Architecture of <i>Pseudomonas aeruginosa</i> glutamyl-tRNA synthetase defines a subfamily of dimeric class Ib aminoacyl-tRNA synthetases
Architecture of <i>Pseudomonas aeruginosa</i> glutamyl-tRNA synthetase defines a subfamily of dimeric class Ib aminoacyl-tRNA synthetases Open
The aminoacyl-tRNA synthetases (AaRSs) are an ancient family of structurally diverse enzymes that are divided into two major classes. The functionalities of most AaRSs are inextricably linked to their oligomeric states. While GluRSs were p…
View article: VN1K: a genome graph-based and function-driven multi-omics and phenomics resource for the Vietnamese population
VN1K: a genome graph-based and function-driven multi-omics and phenomics resource for the Vietnamese population Open
Vietnam, the 16th most populated nation, remains profoundly underrepresented in global genomic databases. Here, we present VN1K, a first-ever comprehensive and well-curated resource of multi-omics data with a wide-range of phenotypic infor…
View article: Exquisite selectivity of griselimycin extends to beta subunit of DNA polymerases from Gram-negative bacterial pathogens
Exquisite selectivity of griselimycin extends to beta subunit of DNA polymerases from Gram-negative bacterial pathogens Open
Griselimycin, a cyclic depsidecapeptide produced by Streptomyces griseus, is a promising lead inhibitor of the sliding clamp component of bacterial DNA polymerases (β-subunit of Escherichia coli DNA pol III). It was previously shown to inh…
View article: Enolase inhibitors as therapeutic leads for Naegleria fowleri infection
Enolase inhibitors as therapeutic leads for Naegleria fowleri infection Open
Infections with the pathogenic free-living amoebae Naegleria fowleri can lead to life-threatening illnesses including catastrophic primary amoebic meningoencephalitis (PAM). Efficacious treatment options for these infections are lacking an…
View article: CT135 mediates the resistance of Chlamydia trachomatis to primate interferon gamma stimulated immune defenses
CT135 mediates the resistance of Chlamydia trachomatis to primate interferon gamma stimulated immune defenses Open
Evading host innate immune defenses is a critical feature of Chlamydia trachomatis infections, and the mechanisms used by C. trachomatis to subvert these pathways are incompletely understood. We screened a library of chimeric…
View article: A divergent protein kinase A regulatory subunit essential for morphogenesis of the human pathogen Leishmania
A divergent protein kinase A regulatory subunit essential for morphogenesis of the human pathogen Leishmania Open
Parasitic protozoa of the genus Leishmania cycle between the phagolysosome of mammalian macrophages, where they reside as rounded intracellular amastigotes, and the midgut of female sand flies, which they colonize as elongated extracellula…
View article: Enolase inhibitors as therapeutic leads for<i>Naegleria fowleri</i>infection
Enolase inhibitors as therapeutic leads for<i>Naegleria fowleri</i>infection Open
Infections with the pathogenic free-living amoebae Naegleria fowleri can lead to life-threatening illnesses including catastrophic primary amebic meningoencephalitis (PAM). Efficacious treatment options for these infections are lacking and…
View article: Shotgun Kinetic Target-Guided Synthesis Approach Enables the Discovery of Small-Molecule Inhibitors against Pathogenic Free-Living Amoeba Glucokinases
Shotgun Kinetic Target-Guided Synthesis Approach Enables the Discovery of Small-Molecule Inhibitors against Pathogenic Free-Living Amoeba Glucokinases Open
Pathogenic free-living amoebae (pFLA) can cause life-threatening central nervous system (CNS) infections and warrant the investigation of new chemical agents to combat the rise of infection from these pathogens. Naegleria fowleri gl…
View article: Characterization of Glucokinases from Pathogenic Free-Living Amoebae
Characterization of Glucokinases from Pathogenic Free-Living Amoebae Open
Infection with pathogenic free-living amoebae, including Naegleria fowleri , Acanthamoeba spp., and Balamuthia mandrillaris , can lead to life-threatening illnesses, primarily because of catastrophic central nervous system involvement. Eff…
View article: The transcriptome of Balamuthia mandrillaris trophozoites for structure-guided drug design
The transcriptome of Balamuthia mandrillaris trophozoites for structure-guided drug design Open
View article: Reevaluation of the effect of dietary restriction on different recombinant inbred lines of male and female mice
Reevaluation of the effect of dietary restriction on different recombinant inbred lines of male and female mice Open
Dietary restriction (DR) was reported to either have no effect or reduce the lifespan of the majority of the 41‐recombinant inbred (RI) lines studied by Liao et al. ( Aging Cell , 2010, 9 , 92). In an appropriately power longevity study ( …
View article: Litter expansion alters metabolic homeostasis in a sex specific manner
Litter expansion alters metabolic homeostasis in a sex specific manner Open
Nutritional manipulations early in life have been shown to influence growth rate and elicit long lasting effects which in turn has been found to impact lifespan. Therefore, we studied the long-term effects of pre-weaning dietary restrictio…
View article: Evolutionary Diversification of Host-Targeted Bartonella Effectors Proteins Derived from a Conserved FicTA Toxin-Antitoxin Module
Evolutionary Diversification of Host-Targeted Bartonella Effectors Proteins Derived from a Conserved FicTA Toxin-Antitoxin Module Open
Proteins containing a FIC domain catalyze AMPylation and other post-translational modifications (PTMs). In bacteria, they are typically part of FicTA toxin-antitoxin modules that control conserved biochemical processes such as topoisomeras…
View article: A Reevaluation of the Effect of Dietary Restriction on Different Recombinant Inbred (RI) Lines of Male and Female Mice
A Reevaluation of the Effect of Dietary Restriction on Different Recombinant Inbred (RI) Lines of Male and Female Mice Open
Dietary restriction (DR) was reported to either have no effect or reduced the lifespan of the majority of the 41-recombinant inbred (RI)-lines studied (Liao et al., 2010). In an appropriately power longevity study (n > 30 mice/group), we m…
View article: A divergent protein kinase A in the human pathogen<i>Leishmania</i>is associated with cell cortex microtubules and controls cell shape
A divergent protein kinase A in the human pathogen<i>Leishmania</i>is associated with cell cortex microtubules and controls cell shape Open
Summary Parasitic protozoa of the genus Leishmania cycle between the phagolysosome of mammalian macrophages, where they reside as rounded intracellular amastigotes, and the midgut of female sand flies, which they colonize as elongated extr…
View article: Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba
Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba Open
Naegleria fowleri is a pathogenic, thermophilic, free-living amoeba which causes primary amebic meningoencephalitis (PAM). Penetrating the olfactory mucosa, the brain-eating amoeba travels along the olfactory nerves, burrowing through the …
View article: Calorie restriction prevents age-related changes in the intestinal microbiota
Calorie restriction prevents age-related changes in the intestinal microbiota Open
The effect of calorie restriction (CR) on the microbiome, fecal metabolome, and colon transcriptome of adult and old male mice was compared. Life-long CR increased microbial diversity and the Bacteroidetes/Firmicutes ratio and prevented th…
View article: Chromatin-Associated Protein Complexes Link DNA Base J and Transcription Termination in <i>Leishmania</i>
Chromatin-Associated Protein Complexes Link DNA Base J and Transcription Termination in <i>Leishmania</i> Open
Leishmania parasites cause a variety of serious human diseases, with no effective vaccine and emerging resistance to current drug therapy. We have previously shown that a novel DNA base called J is critical for transcription termination at…
View article: In silico detection of SARS-CoV-2 specific B-cell epitopes and validation in ELISA for serological diagnosis of COVID-19
In silico detection of SARS-CoV-2 specific B-cell epitopes and validation in ELISA for serological diagnosis of COVID-19 Open
View article: Chromatin-Associated Protein Complexes Link DNA Base J and Transcription Termination in
Chromatin-Associated Protein Complexes Link DNA Base J and Transcription Termination in Open
View article: Multiplexed Functional Assessment of Genetic Variants in CARD11
Multiplexed Functional Assessment of Genetic Variants in CARD11 Open
Genetic testing has increased the number of variants identified in disease genes, but the diagnostic utility is limited by lack of understanding variant function. CARD11 encodes an adaptor protein that expresses dominant-negative and gain-…
View article: <i>Naegleria fowleri:</i>protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba
<i>Naegleria fowleri:</i>protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba Open
Naegleria fowleri is a pathogenic, thermophilic, free-living amoeba which causes primary amebic meningoencephalitis (PAM). Penetrating the olfactory mucosa, the brain-eating amoeba travels along the olfactory nerves, burrowing through the …
View article: Calorie Restriction Prevents Age-Related Changes in the Intestinal Microbiota
Calorie Restriction Prevents Age-Related Changes in the Intestinal Microbiota Open
The effect of calorie restriction (CR) on the microbiome, fecal metabolome, and colon transcriptome of adult and old male mice was compared. Life-long CR increased microbial diversity and the Bacteriodetes / Fermicutes ratio and prevented …
View article: Litter expansion alters metabolic homeostasis in a sexually divergent manner
Litter expansion alters metabolic homeostasis in a sexually divergent manner Open
Nutritional manipulations early in life have been shown to influence growth rate and elicit long lasting effects which in turn has been found to impact lifespan. Therefore, we studied the long-term effects of pre-weaning dietary restrictio…
View article: The transcriptome of<i>Balamuthia mandrillaris</i>trophozoites for structure-based drug design
The transcriptome of<i>Balamuthia mandrillaris</i>trophozoites for structure-based drug design Open
Balamuthia mandrillaris , a pathogenic free-living amoeba (FLA), causes cutaneous skin lesions as well as the brain-eating disease: Balamuthia granulomatous amoebic encephalitis (GAE). These diseases, and diseases caused by other pathogeni…
View article: Chromatin-associated protein complexes link DNA base J and transcription termination in<i>Leishmania</i>
Chromatin-associated protein complexes link DNA base J and transcription termination in<i>Leishmania</i> Open
Unlike most other eukaryotes, Leishmania and other trypanosomatid protozoa have largely eschewed transcriptional control of gene expression; relying instead on post-transcriptional regulation of mRNAs derived from polycistronic transcripti…
View article: In silico detection of SARS-CoV-2 specific B-cell epitopes and validation in ELISA for serological diagnosis of COVID-19
In silico detection of SARS-CoV-2 specific B-cell epitopes and validation in ELISA for serological diagnosis of COVID-19 Open
Rapid generation of diagnostics is paramount to understand epidemiology and to control the spread of emerging infectious diseases such as COVID-19. Computational methods to predict serodiagnostic epitopes that are specific for the pathogen…
View article: A doublecortin-domain protein of Toxoplasma and its orthologues bind to and modify the structure and organization of tubulin polymers
A doublecortin-domain protein of Toxoplasma and its orthologues bind to and modify the structure and organization of tubulin polymers Open
View article: Toward a structome of <scp><i>Acinetobacter baumannii</i></scp> drug targets
Toward a structome of <span><i>Acinetobacter baumannii</i></span> drug targets Open
Acinetobacter baumannii is well known for causing hospital‐associated infections due in part to its intrinsic antibiotic resistance as well as its ability to remain viable on surfaces and resist cleaning agents. In a previous publication, …