Isaiah Taylor
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View article: Uncovering the cellular and molecular drivers of biotherapeutic immunogenicity 9397
Uncovering the cellular and molecular drivers of biotherapeutic immunogenicity 9397 Open
Description Immunogenicity to biologic drugs manifests as the generation of anti-drug antibodies (ADAs), which can significantly impact the safety, efficacy, pharmacokinetics, and pharmacodynamics of biotherapeutic products, potentially re…
View article: Ethylene-independent modulation of root development by ACC via downregulation of WOX5 and group I CLE peptide expression.
Ethylene-independent modulation of root development by ACC via downregulation of WOX5 and group I CLE peptide expression. Open
In seed plants, the canonical role of 1-aminocyclopropane-1-carboxylic acid (ACC) is to serve as the precursor in the biosynthesis of the phytohormone ethylene, and indeed, ACC treatment is often used as a proxy for ethylene treatment. Inc…
View article: Single-cell transcriptomics reveal how root tissues adapt to soil stress
Single-cell transcriptomics reveal how root tissues adapt to soil stress Open
Land plants thrive in soils showing vastly different properties and environmental stresses 1 . Root systems can adapt to contrasting soil conditions and stresses, yet how their responses are programmed at the individual cell scale remains …
View article: Ethylene-independent modulation of root development by ACC via downregulation of WOX5 and group I CLE peptide expression
Ethylene-independent modulation of root development by ACC via downregulation of WOX5 and group I CLE peptide expression Open
In seed plants, the canonical role of 1-aminocyclopropane-1-carboxylic acid (ACC) is to serve as the precursor in the biosynthesis of the phytohormone ethylene, and indeed, ACC treatment is often used as a proxy for ethylene treatment. Inc…
View article: <i>Arabidopsis</i> uses a molecular grounding mechanism and a biophysical circuit breaker to limit floral abscission signaling
<i>Arabidopsis</i> uses a molecular grounding mechanism and a biophysical circuit breaker to limit floral abscission signaling Open
Abscission is the programmed separation of plant organs. It is widespread in the plant kingdom with important functions in development and environmental response. In Arabidopsis, abscission of floral organs (sepals, petals, and stamens) is…
View article: The rhizodynamics robot: Automated imaging system for studying long-term dynamic root growth
The rhizodynamics robot: Automated imaging system for studying long-term dynamic root growth Open
The study of plant root growth in real time has been difficult to achieve in an automated, high-throughput, and systematic fashion. Dynamic imaging of plant roots is important in order to discover novel root growth behaviors and to deepen …
View article: Brassinosteroid gene regulatory networks at cellular resolution in the <i>Arabidopsis</i> root
Brassinosteroid gene regulatory networks at cellular resolution in the <i>Arabidopsis</i> root Open
Brassinosteroids are plant steroid hormones that regulate diverse processes, such as cell division and cell elongation, through gene regulatory networks that vary in space and time. By using time series single-cell RNA sequencing to profil…
View article: <i>SCARECROW‐LIKE28</i> modulates organ growth in Arabidopsis by controlling mitotic cell cycle exit, endoreplication, and cell expansion dynamics
<i>SCARECROW‐LIKE28</i> modulates organ growth in Arabidopsis by controlling mitotic cell cycle exit, endoreplication, and cell expansion dynamics Open
Summary The processes that contribute to plant organ morphogenesis are spatial–temporally organized. Within the meristem, mitosis produces new cells that subsequently engage in cell expansion and differentiation programs. The latter is fre…
View article: Brassinosteroid gene regulatory networks at cellular resolution
Brassinosteroid gene regulatory networks at cellular resolution Open
Brassinosteroids (BRs) are plant steroid hormones that regulate diverse processes such as cell division and cell elongation. BRs control thousands of genes through gene regulatory networks that vary in space and time. By using time-series …
View article: Arabidopsis uses a molecular grounding mechanism and a biophysical circuit breaker to limit floral abscission signaling
Arabidopsis uses a molecular grounding mechanism and a biophysical circuit breaker to limit floral abscission signaling Open
Abscission is the programmed separation of plant organs. It is widespread in the plant kingdom with important functions in development and environmental response. In Arabidopsis, abscission of floral organs (sepals, petals, and stamens) is…
View article: The rhizodynamics robot: Automated imaging system for studying long-term dynamic root growth
The rhizodynamics robot: Automated imaging system for studying long-term dynamic root growth Open
The study of plant root growth in real time has been difficult to achieve in an automated, high-throughput, and systematic fashion. Dynamic imaging of plant roots is important in order to discover novel root growth behaviors and to deepen …
View article: Single-cell genomics revolutionizes plant development studies across scales
Single-cell genomics revolutionizes plant development studies across scales Open
Understanding the development of tissues, organs and entire organisms through the lens of single-cell genomics has revolutionized developmental biology. Although single-cell transcriptomics has been pioneered in animal systems, from an exp…
View article: A single-cell Arabidopsis root atlas reveals developmental trajectories in wild-type and cell identity mutants
A single-cell Arabidopsis root atlas reveals developmental trajectories in wild-type and cell identity mutants Open
In all multicellular organisms, transcriptional networks orchestrate organ development. The Arabidopsis root, with its simple structure and indeterminate growth, is an ideal model for investigating the spatiotemporal transcriptional signat…
View article: SCL28 promotes cell expansion and endoreplication in Arabidopsis by activating<i>SIAMESE-RELATED</i>cyclin-dependent kinase inhibitors
SCL28 promotes cell expansion and endoreplication in Arabidopsis by activating<i>SIAMESE-RELATED</i>cyclin-dependent kinase inhibitors Open
The processes that contribute to plant organ morphogenesis are spatial-temporally organized. Within the meristem the mitotic cell cycle produces new cells that subsequently engage in specific cell expansion and differentiation programs onc…
View article: Mechanism and function of root circumnutation
Mechanism and function of root circumnutation Open
Significance Root growth in soil is complex. With limited sensory input, roots must navigate an environment containing heterogeneities such as rocks and compaction. The ability of roots to penetrate soil is crucial for water and nutrient u…
View article: Data and scripts from: Mechanism and function of root circumnutation
Data and scripts from: Mechanism and function of root circumnutation Open
Early root growth is critical for plant establishment and survival. We have identified a molecular pathway required for helical root tip movement known as circumnutation. Here we report a multiscale investigation of the regulation and func…
View article: VAP-RELATED SUPPRESSORS OF TOO MANY MOUTHS (VST) family proteins are regulators of root system architecture
VAP-RELATED SUPPRESSORS OF TOO MANY MOUTHS (VST) family proteins are regulators of root system architecture Open
Root system architecture (RSA) is a key factor in the efficiency of nutrient capture and water uptake in plants. Understanding the genetic control of RSA will be useful in minimizing fertilizer and water usage in agricultural cropping syst…
View article: A single cell<i>Arabidopsis</i>root atlas reveals developmental trajectories in wild type and cell identity mutants
A single cell<i>Arabidopsis</i>root atlas reveals developmental trajectories in wild type and cell identity mutants Open
Summary Cell fate acquisition is a fundamental developmental process in all multicellular organisms. Yet, much is unknown regarding how a cell traverses the pathway from stem cell to terminal differentiation. Advances in single cell genomi…
View article: VST Family Proteins are Regulators of Root System Architecture in Rice and<i>Arabidopsis</i>
VST Family Proteins are Regulators of Root System Architecture in Rice and<i>Arabidopsis</i> Open
Root System Architecture (RSA) is a key factor in the efficiency of nutrient capture and water uptake in plants. Understanding the genetic control of RSA will be useful in minimizing fertilizer and water usage in agricultural cropping syst…
View article: Mechanism and function of root circumnutation
Mechanism and function of root circumnutation Open
Early root growth is critical for plant establishment and survival. We have identified a molecular pathway required for oscillatory root tip movement known as circumnutation. Here we report a multiscale investigation of the regulation and …
View article: Hypermorphic <i>SERK1</i> Mutations Function via a <i>SOBIR1</i> Pathway to Activate Floral Abscission Signaling
Hypermorphic <i>SERK1</i> Mutations Function via a <i>SOBIR1</i> Pathway to Activate Floral Abscission Signaling Open
In Arabidopsis (Arabidopsis thaliana), the abscission of floral organs is regulated by two related receptor-like protein kinases, HAESA (HAE) and HAESA-LIKE2 (HSL2). In complex with members of the SOMATIC EMBRYOGENESIS RECEPTOR-LIKE…
View article: Hypermorphic<i>SERK1</i>mutations function via a<i>SOBIR1</i>pathway to activate floral abscission signaling
Hypermorphic<i>SERK1</i>mutations function via a<i>SOBIR1</i>pathway to activate floral abscission signaling Open
In Arabidopsis, the abscission of floral organs is regulated by two related receptor-like protein kinases (RLKs), HAESA and HAESA-like 2 (HAE/HSL2). HAE/HSL2, in complex with members of the SERK family of coreceptor protein kinases, are ac…
View article: Transcriptomic evidence for distinct mechanisms underlying abscission deficiency in the Arabidopsis mutants haesa/haesa-like 2 and nevershed
Transcriptomic evidence for distinct mechanisms underlying abscission deficiency in the Arabidopsis mutants haesa/haesa-like 2 and nevershed Open
View article: A histidine kinase gene is required for large radius root tip circumnutation and surface exploration in rice
A histidine kinase gene is required for large radius root tip circumnutation and surface exploration in rice Open
The intricate growth patterns that accompany plant organ elongation have long intrigued biologists 1 . Circumnutation refers to the circular or elliptical growth of the tip of a plant organ around a central axis. While the utility of circu…
View article: Minimum requirements for changing and maintaining endodermis cell identity in the Arabidopsis root
Minimum requirements for changing and maintaining endodermis cell identity in the Arabidopsis root Open
View article: MOESM3 of Transcriptomic evidence for distinct mechanisms underlying abscission deficiency in the Arabidopsis mutants haesa/haesa-like 2 and nevershed
MOESM3 of Transcriptomic evidence for distinct mechanisms underlying abscission deficiency in the Arabidopsis mutants haesa/haesa-like 2 and nevershed Open
Additional file 3: Dataset 2. Output of GO analysis.
View article: MOESM2 of Transcriptomic evidence for distinct mechanisms underlying abscission deficiency in the Arabidopsis mutants haesa/haesa-like 2 and nevershed
MOESM2 of Transcriptomic evidence for distinct mechanisms underlying abscission deficiency in the Arabidopsis mutants haesa/haesa-like 2 and nevershed Open
Additional file 2: Dataset 1. Output of differential expression analysis.
View article: Disrupting ER-associated protein degradation suppresses the abscission defect of a weak <i>hae hsl2</i> mutant in Arabidopsis
Disrupting ER-associated protein degradation suppresses the abscission defect of a weak <i>hae hsl2</i> mutant in Arabidopsis Open
In Arabidopsis thaliana , the process of abscission, or the shedding of unwanted organs, is mediated by two genes, HAESA ( HAE ) and HAESA-LIKE 2 ( HSL2 ), encoding receptor-like protein kinases (RLKs). The double loss-of-function mutant h…
View article: Analysis of Phosphorylation of the Receptor-Like Protein Kinase HAESA during Arabidopsis Floral Abscission
Analysis of Phosphorylation of the Receptor-Like Protein Kinase HAESA during Arabidopsis Floral Abscission Open
Receptor-like protein kinases (RLKs) are the largest family of plant transmembrane signaling proteins. Here we present functional analysis of HAESA, an RLK that regulates floral organ abscission in Arabidopsis. Through in vitro and in vivo…