Ishan Ghai
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View article: Understanding Drug Permeability in Pseudomonas aeruginosa
Understanding Drug Permeability in Pseudomonas aeruginosa Open
Pseudomonas aeruginosa is a Gram-negative bacterium that poses a serious threat to patients with weakened immunity, cystic fibrosis, severe burns, or those in hospitals. Its ability to resist antibiotics comes largely from its outer membra…
View article: Yoga Nidra and Pain: A between-, within-Group Meta-Analysis and Dose Response Meta-Regression
Yoga Nidra and Pain: A between-, within-Group Meta-Analysis and Dose Response Meta-Regression Open
Background: Pain, both acute and chronic, places a substantial burden on global healthcare systems. While conventional treatments may be limited in efficacy due to side effects, risk of dependency, or variable individual response, there is…
View article: Mapping Ammonium Flux Across Bacterial Porins: A Novel Electrophysiological Assay with Antimicrobial Relevance
Mapping Ammonium Flux Across Bacterial Porins: A Novel Electrophysiological Assay with Antimicrobial Relevance Open
This study presents a quantitative electrophysiological method to directly measure the passive transport of ammonium ions through bacterial outer membrane porins. Using a zero-current reversal potential assay in planar lipid bilayers under…
View article: Highly potent quinoxalinediones inhibit α-hemolysin and ameliorate Staphylococcus aureus lung infections
Highly potent quinoxalinediones inhibit α-hemolysin and ameliorate Staphylococcus aureus lung infections Open
Hospital-acquired pneumonia caused by Staphylococcus aureus is associated with patient morbidity and mortality, despite adequate antibiotic therapy. This illustrates the need for treatments beyond antibiotics. The pore-forming heptameric t…
View article: Electrophysiological Insights into Antibiotic Translocation and Resistance: The Impact of Outer Membrane Proteins
Electrophysiological Insights into Antibiotic Translocation and Resistance: The Impact of Outer Membrane Proteins Open
The alarming rise of antibiotic resistance in Gram-negative bacteria has emerged as a major global health challenge. A key factor contributing to this crisis is the low permeability of the bacterial outer membrane, which acts as a barrier …
View article: Influence of taping on joint proprioception: a systematic review with between and within group meta-analysis
Influence of taping on joint proprioception: a systematic review with between and within group meta-analysis Open
Taping is increasingly used to manage proprioceptive deficits, but existing reviews on its impact have shortcomings. To accurately assess the effects of taping, a separate meta-analyses for different population groups and tape types is nee…
View article: Influence of compression garments on proprioception: A systematic review and meta‐analysis
Influence of compression garments on proprioception: A systematic review and meta‐analysis Open
Compression garments (CGs) are commonly used in rehabilitation and sports contexts to enhance performance and speed up recovery. Despite the growing use of CGs in recent decades, there is no unanimous consensus on their overall influence o…
View article: Floor-hugging Intervention: A Perspective on Floor Exposure and After-Fall Contingency Intervention
Floor-hugging Intervention: A Perspective on Floor Exposure and After-Fall Contingency Intervention Open
The fear of falling is a pressing public health issue, yet current interventions often fall short in addressing it effectively. As a result, there is a need for innovative interventions that go beyond symptom relief to address the underlyi…
View article: Fosfomycin Uptake in <i>Escherichia coli</i> Is Mediated by the Outer-Membrane Porins OmpF, OmpC, and LamB
Fosfomycin Uptake in <i>Escherichia coli</i> Is Mediated by the Outer-Membrane Porins OmpF, OmpC, and LamB Open
The antibiotic fosfomycin (FOS) is widely recognized for the treatment of lower urinary tract infections with Escherichia coli and has lately gained importance as a therapeutic option to combat multidrug-resistant bacteria. However, resist…
View article: A Barrier to Entry: Examining the Bacterial Outer Membrane and Antibiotic Resistance
A Barrier to Entry: Examining the Bacterial Outer Membrane and Antibiotic Resistance Open
Gram-negative bacteria can resist antibiotics by changing the permeability via their outer membrane. These bacteria have a complex cell envelope that incorporates an outer membrane separating the periplasm from the external environment. Th…
View article: Auditory Stimulation Improves Gait and Posture in Cerebral Palsy: A Systematic Review with Between- and Within-Group Meta-Analysis
Auditory Stimulation Improves Gait and Posture in Cerebral Palsy: A Systematic Review with Between- and Within-Group Meta-Analysis Open
The past decade has seen an increased interest in the implementation of auditory stimulation (AStim) for managing gait and postural deficits in people with cerebral palsy. Although existing reviews report beneficial effects of AStim on the…
View article: Cephalosporin translocation across enterobacterial OmpF and OmpC channels, a filter across the outer membrane
Cephalosporin translocation across enterobacterial OmpF and OmpC channels, a filter across the outer membrane Open
Gram-negative porins are the main entry for small hydrophilic molecules. We studied translocation of structurally related cephalosporins, ceftazidime (CAZ), cefotaxime (CTX) and cefepime (FEP). CAZ is highly active on E. coli producing Omp…
View article: Uptake of aminoglycosides through outer membrane porins in <i>Escherichia coli</i>
Uptake of aminoglycosides through outer membrane porins in <i>Escherichia coli</i> Open
Aminoglycosides are important clinical antibiotics but their molecular uptake mechanism is still not completely understood. Here we quantify and compare the passive transport of three aminoglycosides (kanamycin, gentamicin, and amikacin) a…
View article: Dataset for Conformational dynamics of loop L3 in OmpF: Implications towards antibiotic translocation and voltage gating
Dataset for Conformational dynamics of loop L3 in OmpF: Implications towards antibiotic translocation and voltage gating Open
Dataset supporting the work in the publication titled, "Conformational dynamics of loop L3 in OmpF: Implications towards antibiotic translocation and voltage gating".
View article: Dataset for Conformational dynamics of loop L3 in OmpF: Implications towards antibiotic translocation and voltage gating
Dataset for Conformational dynamics of loop L3 in OmpF: Implications towards antibiotic translocation and voltage gating Open
Dataset supporting the work in the publication titled, "Conformational dynamics of loop L3 in OmpF: Implications towards antibiotic translocation and voltage gating".
View article: Virtual Reality Enhances Gait in Cerebral Palsy: A Training Dose-Response Meta-Analysis
Virtual Reality Enhances Gait in Cerebral Palsy: A Training Dose-Response Meta-Analysis Open
Virtual-reality-based training can influence gait recovery in children with cerebral palsy. A consensus concerning its influence on spatiotemporal gait parameters and effective training dosage is still warranted. This study analyzes the in…
View article: Effects of (music-based) rhythmic auditory cueing training on gait and posture post-stroke: A systematic review & dose-response meta-analysis
Effects of (music-based) rhythmic auditory cueing training on gait and posture post-stroke: A systematic review & dose-response meta-analysis Open
Gait dysfunctions are common post-stroke. Rhythmic auditory cueing has been widely used in gait rehabilitation for movement disorders. However, a consensus regarding its influence on gait and postural recovery post-stroke is still warrante…
View article: Role of Sonification and Rhythmic Auditory Cueing for Enhancing Gait Associated Deficits Induced by Neurotoxic Cancer Therapies: A Perspective on Auditory Neuroprosthetics
Role of Sonification and Rhythmic Auditory Cueing for Enhancing Gait Associated Deficits Induced by Neurotoxic Cancer Therapies: A Perspective on Auditory Neuroprosthetics Open
Patients undergoing chemotherapy, radiotherapy, and immunotherapy experience neurotoxic changes in the central and peripheral nervous system. These neurotoxic changes adversely affect functioning in the sensory, motor, and cognitive domain…
View article: Virtual Reality Enhances Gait in Cerebral Palsy: A Training Dose-Response Meta-Analysis
Virtual Reality Enhances Gait in Cerebral Palsy: A Training Dose-Response Meta-Analysis Open
Virtual-reality-based training can influence gait recovery in children with cerebral palsy. A consensus concerning its influence on spatiotemporal gait parameters and effective training dosage is still warranted. This study analyzes the in…
View article: Effects of Rhythmic Auditory Cueing in Gait Rehabilitation for Multiple Sclerosis: A Mini Systematic Review and Meta-Analysis
Effects of Rhythmic Auditory Cueing in Gait Rehabilitation for Multiple Sclerosis: A Mini Systematic Review and Meta-Analysis Open
Rhythmic auditory cueing has been shown to enhance gait performance in several movement disorders. The “entrainment effect” generated by the stimulations can enhance auditory motor coupling and instigate plasticity. However, a consensus as…
View article: Understanding antibiotic resistance via outer membrane permeability
Understanding antibiotic resistance via outer membrane permeability Open
Collective antibiotic drug resistance is a global threat, especially with respect to Gram-negative bacteria. The low permeability of the bacterial outer cell wall has been identified as a challenging barrier that prevents a sufficient anti…
View article: Effect of rhythmic auditory cueing on parkinsonian gait: A systematic review and meta-analysis
Effect of rhythmic auditory cueing on parkinsonian gait: A systematic review and meta-analysis Open
The use of rhythmic auditory cueing to enhance gait performance in parkinsonian patients’ is an emerging area of interest. Different theories and underlying neurophysiological mechanisms have been suggested for ascertaining the enhancement…
View article: “Low road” to rehabilitation: a perspective on subliminal sensory neuroprosthetics
“Low road” to rehabilitation: a perspective on subliminal sensory neuroprosthetics Open
Shashank Ghai,1 Ishan Ghai,2 Alfred O Effenberg1 1Institute of Sports Science, Leibniz University Hannover, Hannover, 2School of Life Sciences, Jacobs University, Bremen, Germany Abstract: Fear can propagate parallelly through both cortica…
View article: &ldquo;Low road&rdquo; to rehabilitation: a perspective on subliminal sensory neuroprosthetics
“Low road” to rehabilitation: a perspective on subliminal sensory neuroprosthetics Open
Fear can propagate parallelly through both cortical and subcortical pathways. It can instigate memory consolidation habitually and might allow internal simulation of movements independent of the cortical structures. This perspective sugges…