Explanipedia

Front Cover: Photocatalytic Anticancer Activity of Cyclometalated Ir(III) Complexes: A Mechanistic Insight (Chem. Asian J. 19/2025) Open

Ashish Kumar Yadav, Virendra Singh, Ishwar Singh, Amit Kunwar, Biplob Koch , et al. · 2025

Novltex: A New Class of Antibiotics with Potent Activity against Multidrug-Resistant Bacterial Pathogens─Design, Synthesis, and Biological Evaluation Open

Esra Malkawi, Anish Parmar, Sanjit Das, Enas Newire, C. Hal Jones , et al. · 2025

Increasing spread of multidrug-resistant (MDR) bacteria demands antibiotics that combine potent activity with scalable synthesis. Novo29 (clovibactin) is promising but suffers from low yield (1%), dependence on costly and noncommercial d-h…

Effect of Organic Manure and Bio Fertilizer on Growth and Yield of Groundnut (Arachis hypogea L.) Open

Ishwar Singh, Vikram Singh, Amit Kumar, Sunil Kumar · 2025

A field experiment was conducted during the Kharif season of 2024 at Crop Research Farm Department of Agronomy, Naini Agriculture Institute, Sam Higginbottom University of Agriculture Technology and Sciences. The present study determines t…

Effect of split application of nitrogen at different growth stages on early sown wheat (Triticum aestivum L.) Open

Angella Mhango, Ishwar Singh, M. A. Rana, Ridhima Arya · 2024

Wheat stands as a primary grain crop globally, used for food in human and feed for animals. The aim of this research was to investigate the impact of split application of nitrogen at different growth stages of early sown wheat (Triticum ae…

New Teixobactin Analogues with a Total Lactam Ring Open

Giuseppe Scioli, Lorenza Marinaccio, Marta Bauer, Wojciech Kamysz, Anish Parmar , et al. · 2023

Teixobactin is a new antibiotic peptide with strong efficacy against several Gram-positive resistant bacteria, the structure of which is extremely difficult to obtain in the laboratory via multistep conventional synthesis. To face the incr…

Development of teixobactin analogues containing hydrophobic, non-proteogenic amino acids that are highly potent against multidrug-resistant bacteria and biofilms Open

Anish Parmar, Rajamani Lakshminarayanan, Abhishek Iyer, Eunice Tze Leng Goh, Tsz Ying To , et al. · 2023

Analyzing mechanisms of action of antimicrobial peptides on bacterial membranes requires multiple complimentary assays and different bacterial strains Open

Xiaoqi Wang, Roy A. M. van Beekveld, Yang Xu, Anish Parmar, Sanjit Das , et al. · 2023

Antimicrobial peptides (AMPs) commonly target bacterial membranes and show broad-spectrum activity against microorganisms. In this research we used three AMPs (nisin, epilancin 15×, [R4L10]-teixobactin) and tested their membrane effects to…

Inhibitory activity of hydroalcoholic extract of Anancardium occidentale L. leaves against Brugia malayi hexokinase, a target for anti-filarial drug development Open

Meenakshi Kaushik, S. L. Hoti, Jitendra Kumar Saxena, Rajesh K. Joshi, Ishwar Singh , et al. · 2023

Purpose: Globally, 859 million people in 50 countries are threatened by lymphatic filariasis. Due to its severity, the available drugs are mainly used for microfilaricidal and do not kill efficiently the adult parasites, which continue to …

CCDC 2151983: Experimental Crystal Structure Determination Open

Alex J. Veinot, Matthew B. E. Griffiths, Ishwar Singh, Joseph A. Zurakowski, Paul A. Lummis , et al. · 2022

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 2151982: Experimental Crystal Structure Determination Open

Alex J. Veinot, Matthew B. E. Griffiths, Ishwar Singh, Joseph A. Zurakowski, Paul A. Lummis , et al. · 2022

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Mode of action of teixobactins in cellular membranes Open

Rhythm Shukla, João Medeiros‐Silva, Anish Parmar, Bram J. A. Vermeulen, Sanjit Das , et al. · 2020

Cysteines and Disulfide-Bridged Macrocyclic Mimics of Teixobactin Analogues and Their Antibacterial Activity Evaluation against Methicillin-Resistant Staphylococcus Aureus (MRSA) Open

Ruba Malkawi, Abhishek Iyer, Anish Parmar, Daniel G. Lloyd, Eunice Tze Leng Goh , et al. · 2018

Teixobactin is a highly potent cyclic depsipeptide which kills a broad range of multi-drug resistant, Gram-positive bacteria, such as Methicillin-resistant Staphylococcus aureus (MRSA) without detectable resistance. In this work, we descri…

Anomalous Electrical Resistivity and Hall Constant of Anderson Lattice with Finite f-Band width Open

Sanjay Panwar, Ishwar Singh · 2018

We study here an extension of the periodic Anderson model by considering finite f-band width. A variational method is used to study the temperature dependence of electronic transport properties of Anderson lattice for different values of t…

Design and Syntheses of Highly Potent Teixobactin Analogues against Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococci (VRE) in Vitro and in Vivo Open

Anish Parmar, Rajamani Lakshminarayanan, Abhishek Iyer, Venkatesh Mayandi, Eunice Tze Leng Goh , et al. · 2018

The cyclic depsipeptide, teixobactin, kills a number of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and Mycobacterium tuberculosis without detectable resistance. To date, teixobactin is the only mo…

CCDC 1836394: Experimental Crystal Structure Determination Open

P. Lucaioli, Elisa Nauha, Ilaria Gimondi, Louise S. Price, Rui Guo , et al. · 2018

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1579696: Experimental Crystal Structure Determination Open

P. Lucaioli, Elisa Nauha, Ishwar Singh, N. Blagden · 2018

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1579695: Experimental Crystal Structure Determination Open

P. Lucaioli, Elisa Nauha, Ishwar Singh, N. Blagden · 2018

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Influence of various macro and micro plant nutrients on the productivity of sugarcane (saccharum Sp. hybrid) Open

Satendra Kumar, SC Singh, S.P. Yadav, Sneha Rai, S Ahamed Ali , et al. · 2018

CCDC 1579698: Experimental Crystal Structure Determination Open

P. Lucaioli, Elisa Nauha, Ishwar Singh, N. Blagden · 2018

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1579697: Experimental Crystal Structure Determination Open

P. Lucaioli, Elisa Nauha, Ishwar Singh, N. Blagden · 2018

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1836683: Experimental Crystal Structure Determination Open

P. Lucaioli, Elisa Nauha, Ilaria Gimondi, Louise S. Price, Rui Guo , et al. · 2018

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Simplified Teixobactin Analogues to Target Superbugs Open

Ishwar Singh · 2017

Ishwar Singh speaks to Benjamin Walden, Commissioning Editor. Ishwar Singh is a Senior Lecturer in biological chemistry at the School of Pharmacy, University of Lincoln. Prior to Lincoln, he had held many prestigious fellowships such as th…

Exposure to febrile-range hyperthermia potentiates Wnt signalling and epithelial–mesenchymal transition gene expression in lung epithelium Open

Ratnakar Potla, Mohan E. Tulapurkar, Irina G. Luzina, Sergei P. Atamas, Ishwar Singh , et al. · 2017

Wnt responsiveness, including expression of genes associated with EMT, increases after exposure to febrile-range temperature through an HSF1-dependent mechanism that is independent of previously identified temperature-dependent miRNAs. Thi…

Novel Noncatalytic Substrate-Selective p38α-Specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-Inflammatory Activity Open

Nirav G. Shah, Mohan E. Tulapurkar, Aparna Ramarathnam, Amanda Brophy, Ramón Martínez , et al. · 2017

The p38 MAPK family is composed of four kinases of which p38α/MAPK14 is the major proinflammatory member. These kinases contribute to many inflammatory diseases, but the currently available p38 catalytic inhibitors (e.g., SB203580) are poo…

Relative performance of sugarcane varieties under alkaline soil condition in eastern Uttar Pradesh Open

Koushik Pal, K.K. Singh, Ishwar Singh, B.L. Sharma · 2017

Effect of different sugarcane genotypes and fertility levels on productivity of sugaracene Open

Satendra Kumar, Ishwar Singh, S.C. Singh, B.L. Sharma · 2017

Screening of promising sugarcane genotypes for resistance to red rot disease (Colletotrichum falcatum) in eastern Uttar Pradesh Open

Y. P. Bharti, Vijai Singh, Atul Singh, Ishwar Singh, B.L. Sharma · 2017

Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding Open

Anish Parmar, Abhishek Iyer, Stephen H. Prior, Daniel G. Lloyd, Eunice Tze Leng Goh , et al. · 2017

Leu₁₀-teixobactin and Ile₁₀-teixobactin have shown comparable activity to natural teixobactin.

Defining the molecular structure of teixobactin analogues and understanding their role in antibacterial activities Open

Anish Parmar, Stephen H. Prior, Abhishek Iyer, Charlotte S. Vincent, Dorien Van Lysebetten , et al. · 2017

In this work, we have for the first time defined the molecular structure of seven teixobactin analogues through the variation of the d/l configuration of its key residues.

Activation of heat shock response augments fibroblast growth factor-1 expression in wounded lung epithelium Open

R.G. Scheraga, Christopher M. Thompson, Mohan E. Tulapurkar, Ashish Nagarsekar, Mark J. Cowan , et al. · 2016

We previously showed that coincident exposure to heat shock (HS; 42°C for 2 h) and TNF-α synergistically induces apoptosis in mouse lung epithelium. We extended this work by analyzing HS effects on human lung epithelial responses to clinic…

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