Ísleifur Ólafsson
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View article: Increased risk of infections in smoldering multiple myeloma: results from the screened iStopMM study
Increased risk of infections in smoldering multiple myeloma: results from the screened iStopMM study Open
Infections are a major cause of morbidity and mortality in multiple myeloma (MM). While increased infection risk has been shown in monoclonal gammopathy of undetermined significance (MGUS), data are limited for smoldering multiple myeloma …
View article: Next-generation flow cytometry analysis of clonal bone marrow plasma cells identifies an indolent subset of MGUS
Next-generation flow cytometry analysis of clonal bone marrow plasma cells identifies an indolent subset of MGUS Open
View article: Identification of cystatin C as a new marker of glomerular filtration rate, and of shrunken pore syndrome – a new kidney disorder defining selective glomerular hypofiltration syndromes – calls for expansion of the international KDIGO guidelines
Identification of cystatin C as a new marker of glomerular filtration rate, and of shrunken pore syndrome – a new kidney disorder defining selective glomerular hypofiltration syndromes – calls for expansion of the international KDIGO guidelines Open
Cystatin C was identified as a marker of glomerular filtration rate (GFR) in 1979, and the parallel analysis of cystatin C and creatinine led to the identification of shrunken pore syndrome (SPS) - a new kidney disorder - in 2015. Since th…
View article: Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum
Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum Open
Genome-wide association studies (GWASs) may help inform the etiology of infertility. Here, we perform GWAS meta-analyses across seven cohorts in up to 42,629 cases and 740,619 controls and identify 25 genetic risk loci for male and female …
View article: Analysis of smoldering multiple myeloma according to the target of the monoclonal immunoglobulin of patients
Analysis of smoldering multiple myeloma according to the target of the monoclonal immunoglobulin of patients Open
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View article: Genome-wide analyses identify 21 infertility loci and over 400 reproductive hormone loci across the allele frequency spectrum
Genome-wide analyses identify 21 infertility loci and over 400 reproductive hormone loci across the allele frequency spectrum Open
Genome-wide association studies (GWASs) may help inform treatments for infertility, whose causes remain unknown in many cases. Here we present GWAS meta-analyses across six cohorts for male and female infertility in up to 41,200 cases and …
View article: X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements
X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements Open
X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-rel…
View article: X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements
X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements Open
View article: Prior cancer and risk of monoclonal gammopathy of undetermined significance: a population-based study in Iceland and Sweden
Prior cancer and risk of monoclonal gammopathy of undetermined significance: a population-based study in Iceland and Sweden Open
There is some evidence that a prior cancer is a risk factor for the development of multiple myeloma (MM). If this is true, prior cancer should be associated with higher prevalence or increased progression rate of monoclonal gammopathy of u…
View article: Variants at the Interleukin 1 Gene Locus and Pericarditis
Variants at the Interleukin 1 Gene Locus and Pericarditis Open
Importance Recurrent pericarditis is a treatment challenge and often a debilitating condition. Drugs inhibiting interleukin 1 cytokines are a promising new treatment option, but their use is based on scarce biological evidence and clinical…
View article: P894: INFECTION RISK BEFORE DIAGNOSIS OF MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE: RESULTS FROM THE SCREENED POPULATION-BASED ISTOPMM STUDY
P894: INFECTION RISK BEFORE DIAGNOSIS OF MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE: RESULTS FROM THE SCREENED POPULATION-BASED ISTOPMM STUDY Open
Topic: 13. Myeloma and other monoclonal gammopathies - Biology & Translational Research Background: Infections have often been hypothesized to play an etiological role in multiple myeloma (MM) and monoclonal gammopathy of undetermined sign…
View article: P900: INVOLVED/UNINVOLVED SERUM FREE LIGHT CHAIN RATIO IS A STRONGER PREDICTOR OF DIAGNOSTIC/RISK FACTORS IN LIGHT CHAIN COMPARED TO HEAVY CHAIN MONOCLONAL GAMMOPATHIES
P900: INVOLVED/UNINVOLVED SERUM FREE LIGHT CHAIN RATIO IS A STRONGER PREDICTOR OF DIAGNOSTIC/RISK FACTORS IN LIGHT CHAIN COMPARED TO HEAVY CHAIN MONOCLONAL GAMMOPATHIES Open
Topic: 14. Myeloma and other monoclonal gammopathies - Clinical Background: Light chain (LC) monoclonal gammopathy of undetermined significance (MGUS) is not well characterized. It is primarily considered a precursor of LC multiple myeloma…
View article: P950: PRIOR CANCER AND RISK OF MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE (MGUS): A POPULATION-BASED STUDY IN ICELAND AND SWEDEN
P950: PRIOR CANCER AND RISK OF MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE (MGUS): A POPULATION-BASED STUDY IN ICELAND AND SWEDEN Open
Topic: 14. Myeloma and other monoclonal gammopathies - Clinical Background: Second primary malignancies (SPM) can be a complication of cancer therapy or be due to shared genetic or environmental risk factors. SPM are well known after multi…
View article: Disease associations with monoclonal gammopathy of undetermined significance can only be evaluated using screened cohorts: results from the population-based iStopMM study
Disease associations with monoclonal gammopathy of undetermined significance can only be evaluated using screened cohorts: results from the population-based iStopMM study Open
Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic precursor condition that precedes multiple myeloma and related disorders but has also been associated with other medical conditions. Since systematic screening is…
View article: Physical and cognitive impact following SARS-CoV-2 infection in a large population-based case-control study
Physical and cognitive impact following SARS-CoV-2 infection in a large population-based case-control study Open
Background Persistent symptoms are common after SARS-CoV-2 infection but correlation with objective measures is unclear. Methods We invited all 3098 adults who tested SARS-CoV-2 positive in Iceland before October 2020 to the deCODE Health …
View article: Author Correction: The power of genetic diversity in genome-wide association studies of lipids
Author Correction: The power of genetic diversity in genome-wide association studies of lipids Open
View article: Author Correction: The power of genetic diversity in genome-wide association studies of lipids
Author Correction: The power of genetic diversity in genome-wide association studies of lipids Open
Correction to "The power of genetic diversity in genome-wide association studies of lipids"
View article: Correction: Iceland screens, treats, or prevents multiple myeloma (iStopMM): a population-based screening study for monoclonal gammopathy of undetermined significance and randomized controlled trial of follow-up strategies
Correction: Iceland screens, treats, or prevents multiple myeloma (iStopMM): a population-based screening study for monoclonal gammopathy of undetermined significance and randomized controlled trial of follow-up strategies Open
View article: Author Correction: Prevalence of smoldering multiple myeloma based on nationwide screening
Author Correction: Prevalence of smoldering multiple myeloma based on nationwide screening Open
View article: Prevalence of smoldering multiple myeloma based on nationwide screening
Prevalence of smoldering multiple myeloma based on nationwide screening Open
View article: Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis Open
View article: The complexity of kidney disease and diagnosing it – cystatin C, selective glomerular hypofiltration syndromes and proteome regulation
The complexity of kidney disease and diagnosing it – cystatin C, selective glomerular hypofiltration syndromes and proteome regulation Open
Estimation of kidney function is often part of daily clinical practice, mostly done by using the endogenous glomerular filtration rate (GFR)‐markers creatinine or cystatin C. A recommendation to use both markers in parallel in 2010 has res…
View article: Sars-Cov-2 Vaccinations Do Not Lead to Progression of Monoclonal Gammopathy of Undetermined Significance: Results from the Population-Based Istopmm Screening Study
Sars-Cov-2 Vaccinations Do Not Lead to Progression of Monoclonal Gammopathy of Undetermined Significance: Results from the Population-Based Istopmm Screening Study Open
Background: In patients with monoclonal gammopathy of undetermined significance (MGUS), the pre-malignant cells are antibody producing plasma cells. Stimulating humoral immunity mediated by plasma cells is an important factor in vaccine ef…
View article: Multiomics study of nonalcoholic fatty liver disease
Multiomics study of nonalcoholic fatty liver disease Open
View article: Defining new reference intervals for serum free light chains in individuals with chronic kidney disease: Results of the iStopMM study
Defining new reference intervals for serum free light chains in individuals with chronic kidney disease: Results of the iStopMM study Open
Serum free light chain (FLC) concentration is greatly affected by kidney function. Using a large prospective population-based cohort, we aimed to establish a reference interval for FLCs in persons with chronic kidney disease (CKD). A total…
View article: HLA alleles, disease severity, and age associate with T-cell responses following infection with SARS-CoV-2
HLA alleles, disease severity, and age associate with T-cell responses following infection with SARS-CoV-2 Open
View article: A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids Open
A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wi…
View article: A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids Open
View article: The sequences of 150,119 genomes in the UK Biobank
The sequences of 150,119 genomes in the UK Biobank Open
Detailed knowledge of how diversity in the sequence of the human genome affects phenotypic diversity depends on a comprehensive and reliable characterization of both sequences and phenotypic variation. Over the past decade, insights into t…
View article: Genetic architecture of band neutrophil fraction in Iceland
Genetic architecture of band neutrophil fraction in Iceland Open