Ismail A. Abdelhamid
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View article: Novel Cyanoacrylamides Incorporating Sulfamethoxazole as Potential Anticancer Agents: DNA Interaction, Apoptotic Induction, and S-Phase Cell Cycle Arrest in Colon Cancer Cells
Novel Cyanoacrylamides Incorporating Sulfamethoxazole as Potential Anticancer Agents: DNA Interaction, Apoptotic Induction, and S-Phase Cell Cycle Arrest in Colon Cancer Cells Open
In the current study, five novel cyanoacrylamides incorporating sulfamethoxazole (5-9) were designed and synthesized as potential candidates for anticancer therapy. The antitumor potential of the synthesized compounds was screened a…
View article: Chitosan-ZnO Nanocomposite Nanocatalyst for the Synthesis of 12-Azatetraphene-8-one and 7-Azatetraphene-11-one Derivatives via Unsymmetrical Hantzsch-Like Reactions
Chitosan-ZnO Nanocomposite Nanocatalyst for the Synthesis of 12-Azatetraphene-8-one and 7-Azatetraphene-11-one Derivatives via Unsymmetrical Hantzsch-Like Reactions Open
The chitosan-ZnO nanocomposite nanocatalyst was employed as a robust, recyclable, and environmentally benign catalyst to efficiently facilitate the regioselective Hantzsch-like multicomponent reactions involving one-mole equivalent of an a…
View article: Novel Hybrid Heterocycles Based on 1,4-Diphenylpiperazine Moiety: Synthesis via Hantzsch and Biginelli Reactions, Molecular Docking Simulation, and Antimicrobial Activities
Novel Hybrid Heterocycles Based on 1,4-Diphenylpiperazine Moiety: Synthesis via Hantzsch and Biginelli Reactions, Molecular Docking Simulation, and Antimicrobial Activities Open
In this study, we have developed new hybrid compounds by connecting bis-heterocycles with the 1,4-diphenylpiperazine core. This is performed by combining 4,4'-(piperazine-1,4-diyl)-dibenzaldehyde with the necessary reagents via Hantzsch an…
View article: Metformin as a novel organic foliar bio-stimulant to enhance peanut (Arachis hypogaea L.) growth and yield under drought stress conditions
Metformin as a novel organic foliar bio-stimulant to enhance peanut (Arachis hypogaea L.) growth and yield under drought stress conditions Open
Background Drought stress significantly affects peanut ( Arachis hypogaea L.) growth and yield, necessitating strategies to enhance crop resilience. This study evaluates the impact of foliar-applied Metformin, gibberellic acid (GA₃), and i…
View article: Synthesis and Evaluation of Novel Bis-Chalcone Derivatives Containing a Thiophene Moiety as Potential Anticancer Agents: In Vitro, In Silico , and Mechanistic Studies
Synthesis and Evaluation of Novel Bis-Chalcone Derivatives Containing a Thiophene Moiety as Potential Anticancer Agents: In Vitro, In Silico , and Mechanistic Studies Open
Chalcone compounds have demonstrated potent anticancer activities in the past few decades with few adverse consequences. Using Claisen-Schmidt condensation, two new series of bis-chalcone derivatives (5a-c and 9a-c<…
View article: Synthesis of novel hybrid heterocycles tethered 2,3-diphenoxyquinoxaline moiety via Michael addition reaction
Synthesis of novel hybrid heterocycles tethered 2,3-diphenoxyquinoxaline moiety via Michael addition reaction Open
View article: Synthesis, and antibacterial activities of novel 1,3,4a,9-tetraza-4H-fluoren-2-amines incorporating phenoxy-N-arylacetamide, pyrazole, and 2-(4-(1-phenyl-1H-pyrazol-3-yl)phenoxy)-N-arylacetamide moieties
Synthesis, and antibacterial activities of novel 1,3,4a,9-tetraza-4H-fluoren-2-amines incorporating phenoxy-N-arylacetamide, pyrazole, and 2-(4-(1-phenyl-1H-pyrazol-3-yl)phenoxy)-N-arylacetamide moieties Open
View article: Synthesis, cytotoxic evaluation, and binding studies of novel sulphamethoxazole-based cyanoacrylamides as potential antitumor agents
Synthesis, cytotoxic evaluation, and binding studies of novel sulphamethoxazole-based cyanoacrylamides as potential antitumor agents Open
Molecular hybridization has become a leading and highly effective method for creating new anticancer chemotherapeutic drugs. In this endeavor, new cyanoacrylamides with derivatives of sulphamethoxazole (5a-5f) have been created and verifie…
View article: Integrative multi-omics analysis of autism spectrum disorder reveals unique microbial macromolecules interactions
Integrative multi-omics analysis of autism spectrum disorder reveals unique microbial macromolecules interactions Open
View article: Green synthesis of novel hexahydroquinolines and 6-amino-2-oxopyridine-3,5-dicarbonitriles incorporating sulfaguanidine via [3 + 3] atom combination
Green synthesis of novel hexahydroquinolines and 6-amino-2-oxopyridine-3,5-dicarbonitriles incorporating sulfaguanidine via [3 + 3] atom combination Open
The synthesis of sulfa drugs has received extensive interest from researchers for their broad spectrum of biological activities. In this context, N-Carbamimidoyl-4-((5,5-dimethyl-3-oxocyclohex-1-en-1-yl)amino)benzenesulfonamide 3 was readi…
View article: Synthesis and antimicrobial evaluation of a new hybrid bis-cyanoacrylamide-based-piperazine containing sulphamethoxazole moiety against rheumatoid arthritis-associated pathogens
Synthesis and antimicrobial evaluation of a new hybrid bis-cyanoacrylamide-based-piperazine containing sulphamethoxazole moiety against rheumatoid arthritis-associated pathogens Open
Piperazine-based compounds have garnered significant attention due to their notable biological and pharmacological activities, making them essential in fine chemical and pharmaceutical applications. In this study, we managed to synthesize …
View article: Design, in silico studies and biological evaluation of novel chalcones tethered triazolo[3,4-a]isoquinoline as EGFR inhibitors targeting resistance in non-small cell lung cancer
Design, in silico studies and biological evaluation of novel chalcones tethered triazolo[3,4-a]isoquinoline as EGFR inhibitors targeting resistance in non-small cell lung cancer Open
A novel series of six [1,2,4]triazolo[3,4- a ]isoquinolin-3-yl)-3-(1,3-diphenyl-1 H -pyrazol-4-yl)prop-2-en-1-ones ( 3a – 3f ) was designed and synthesized. They were characterized based on spectral and elemental analyses. In silico studie…
View article: Novel thiazole-based cyanoacrylamide derivatives: DNA cleavage, DNA/BSA binding properties and their anticancer behaviour against colon and breast cancer cells
Novel thiazole-based cyanoacrylamide derivatives: DNA cleavage, DNA/BSA binding properties and their anticancer behaviour against colon and breast cancer cells Open
A novel series of 2-cyano-3-(pyrazol-4-yl)- N -(thiazol-2-yl)acrylamide derivatives ( 3a – f ) were synthesized using Knoevenagel condensation and characterized using various spectral tools. The weak nuclease activity of compounds (3a – f)…
View article: Synthesis of novel scaffolds based on bis-thiazole linked to piperazine core as new hybrid molecules
Synthesis of novel scaffolds based on bis-thiazole linked to piperazine core as new hybrid molecules Open
View article: Synthesis of novel star-shaped molecules based on a pentaerythritol core linked to different heterocyclic systems
Synthesis of novel star-shaped molecules based on a pentaerythritol core linked to different heterocyclic systems Open
Synthesis of analogs of known active compounds is the most often employed strategy for producing important compounds. The Hantzsch reaction was employed to create new star-shaped compounds with a pentaerythritol core connected to thiazoles…
View article: Synthesis, molecular docking simulation, and antimicrobial activities of novel bis-heterocycles linked to piperazine and vanillin units as novel hybrid molecules via Hantzsch, Biginelli, and Michael’s reactions
Synthesis, molecular docking simulation, and antimicrobial activities of novel bis-heterocycles linked to piperazine and vanillin units as novel hybrid molecules via Hantzsch, Biginelli, and Michael’s reactions Open
Bacterial infections are a global issue, causing sickness and death, mainly in developing nations. Resistance to current medicines is a significant issue in healthcare. Overcoming the resistance problem will necessitate the development of …
View article: Synthesis, cytotoxicity, anti-inflammatory, anti-metastatic and anti-oxidant activities of novel chalcones incorporating 2-phenoxy-N-arylacetamide and thiophene moieties: induction of apoptosis in MCF7 and HEP2 cells
Synthesis, cytotoxicity, anti-inflammatory, anti-metastatic and anti-oxidant activities of novel chalcones incorporating 2-phenoxy-N-arylacetamide and thiophene moieties: induction of apoptosis in MCF7 and HEP2 cells Open
View article: One-pot three-component synthesis of 6-aryl-3-(arylamino)-5H-thiazolo[3',2':1,2]pyrimido[4,5-b]quinolines utilizing 4-amino-6-oxo-pyrimidin-tethered N-aryl-2-mercaptoacetamides as precursors
One-pot three-component synthesis of 6-aryl-3-(arylamino)-5H-thiazolo[3',2':1,2]pyrimido[4,5-b]quinolines utilizing 4-amino-6-oxo-pyrimidin-tethered N-aryl-2-mercaptoacetamides as precursors Open
New thiazolo[3',2':1,2]pyrimido [4,5-b]quinolines were synthesized in good yields using a three-component Hantzsch reaction comprising the appropriate aldehyde and one mole each of 6-aminothiouracil and 5,5dimethyl-1,3-cyclohexanedione.The…
View article: Synthesis of new bis-heterocyclic hybrids linked by iso-propanol unit via Hantzsch, Michael, and Biginelli reactions
Synthesis of new bis-heterocyclic hybrids linked by iso-propanol unit via Hantzsch, Michael, and Biginelli reactions Open
View article: Novel hybrid thiazoles, bis-thiazoles linked to azo-sulfamethoxazole: Synthesis, docking, and antimicrobial activity
Novel hybrid thiazoles, bis-thiazoles linked to azo-sulfamethoxazole: Synthesis, docking, and antimicrobial activity Open
The reaction of sulfamethoxazolehydrazonoyl chloride with thiosemicarbazones, bis-thiosemicarbazones, or 4-amino-3-mercapto-1,2,4-triazole in dioxane in the presence of triethylamine as a basic catalyst at reflux resulted in the regioselec…
View article: Utility of 2-Chloro-<i>N</i>-arylacetamide and 1,1′-(Piperazine-1,4-diyl)bis(2-chloroethanone) as Versatile Precursors for Novel Mono- and Bis[thienopyridines]
Utility of 2-Chloro-<i>N</i>-arylacetamide and 1,1′-(Piperazine-1,4-diyl)bis(2-chloroethanone) as Versatile Precursors for Novel Mono- and Bis[thienopyridines] Open
A series of novel thieno[2,3-b]pyridines linked to N-aryl carboxamides or (carbonylphenoxy)-N-(aryl)acetamides, as well as bis(thieno[2,3-b]pyridines) linked to piperazine core via methanone or carbonylphenoxyet…
View article: Synthesis of Novel Diphenyl Ether-Based Bis-Heterocycles as Novel Hybrid Molecules via Michael and Other Cyclocondensation Reactions
Synthesis of Novel Diphenyl Ether-Based Bis-Heterocycles as Novel Hybrid Molecules via Michael and Other Cyclocondensation Reactions Open
Molecular hybridization is a technique used in drug creation that involves combining the pharmacophoric moieties of multiple bioactive compounds to create a new hybrid molecule with better affinity and effectiveness. In this regard, we cre…
View article: Synthesis, anticancer evaluation of novel hybrid pyrazole-based chalcones, molecular docking, DNA fragmentation, and gene expression: <i>in vitro</i> studies
Synthesis, anticancer evaluation of novel hybrid pyrazole-based chalcones, molecular docking, DNA fragmentation, and gene expression: <i>in vitro</i> studies Open
A new series of pyrazole-based chalcones were synthesized and tested against MCF7, PC3, PACA2 and BJ1 as in vitro study. Gene expression, DNA damage, DNA fragmentation and molecular docking for were discussed.
View article: 2-Oxo-2-(arylamino)ethyl 4-formylbenzoates: Aldehyde precursors for the synthesis of new 2-amino-3-cyano-1,4-dihydropyrans
2-Oxo-2-(arylamino)ethyl 4-formylbenzoates: Aldehyde precursors for the synthesis of new 2-amino-3-cyano-1,4-dihydropyrans Open
View article: Novel 3-(pyrazol-4-yl)-2-(1H-indole-3-carbonyl)acrylonitrile derivatives induce intrinsic and extrinsic apoptotic death mediated P53 in HCT116 colon carcinoma
Novel 3-(pyrazol-4-yl)-2-(1H-indole-3-carbonyl)acrylonitrile derivatives induce intrinsic and extrinsic apoptotic death mediated P53 in HCT116 colon carcinoma Open
View article: Yttrium Oxide nanoparticles induce cytotoxicity, genotoxicity, apoptosis, and ferroptosis in the human triple-negative breast cancer MDA-MB-231 cells
Yttrium Oxide nanoparticles induce cytotoxicity, genotoxicity, apoptosis, and ferroptosis in the human triple-negative breast cancer MDA-MB-231 cells Open
Background Triple-negative breast cancer (TNBC) is a lethal mammary carcinoma subtype that affects females and is associated with a worse prognosis. Chemotherapy is the only conventional therapy available for patients with TNBC due to the …
View article: Novel Scaffolds Based on Bis-thiazole Connected to Quinoxaline or Thienothiophene through 2-Phenoxy-<i>N</i>-arylacetamide Groups as New Hybrid Molecules: Synthesis, Antibacterial Activity, and Molecular Docking Investigations
Novel Scaffolds Based on Bis-thiazole Connected to Quinoxaline or Thienothiophene through 2-Phenoxy-<i>N</i>-arylacetamide Groups as New Hybrid Molecules: Synthesis, Antibacterial Activity, and Molecular Docking Investigations Open
The resistance of microorganisms to antimicrobials has endangered the health of many people across the world. Overcoming the resistance problem will require the invention of molecules with a new mechanism of action so that no cross-resista…
View article: In silico and in vitro studies of novel cyanoacrylamides incorporating pyrazole moiety against breast and prostate carcinomas
In silico and in vitro studies of novel cyanoacrylamides incorporating pyrazole moiety against breast and prostate carcinomas Open
We report novel cyanoacrylamide derivatives bearing the pyrazole moiety. The molecular structures of the prepared cyanoacrylamides were confirmed by the different spectral tools such as NMR, IR, and elemental analyses. The anticancer effec…
View article: Novel Tetrahydro-[1,2,4]triazolo[3,4-a]isoquinoline Chalcones Suppress Breast Carcinoma through Cell Cycle Arrests and Apoptosis
Novel Tetrahydro-[1,2,4]triazolo[3,4-a]isoquinoline Chalcones Suppress Breast Carcinoma through Cell Cycle Arrests and Apoptosis Open
Chalcones are interesting anticancer drug candidates which have attracted much interest due to their unique structure and their extensive biological activity. Various functional modifications in chalcones have been reported, along with the…
View article: New Azacycles by One‐Pot Three‐Component Hantzsch‐Like Synthesis of Tetra(hexa)azacyclopenta[<i>a</i>]anthracenes, Tetraazaindeno[5,4‐<i>b</i>]fluorenes, and Oxatetraazacyclopenta[<i>m</i>]tetraphenes
New Azacycles by One‐Pot Three‐Component Hantzsch‐Like Synthesis of Tetra(hexa)azacyclopenta[<i>a</i>]anthracenes, Tetraazaindeno[5,4‐<i>b</i>]fluorenes, and Oxatetraazacyclopenta[<i>m</i>]tetraphenes Open
New Azacycles by One‐Pot Three‐Component Hantzsch‐Like Synthesis of Tetra(hexa)azacyclopenta[ a ]anthracenes, Tetraazaindeno[5,4‐ b ]fluorenes, and Oxatetraazacyclopenta[ m ]tetraphenes (H. Butenschön, I. A. Abdelhamid et al.) #OpenAccess …