İsmail Cinel
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View article: Machine Learning to Predict Disease Severity and Progression in Hospitalized COVID-19 Patients Using Laboratory Data on Admission
Machine Learning to Predict Disease Severity and Progression in Hospitalized COVID-19 Patients Using Laboratory Data on Admission Open
Background: Herein, we aimed to develop and test machine learning (ML) models to predict disease severity and/or progression in hospitalized COVID-19 patients through baseline laboratory features. Methods: In this retrospective study of ho…
View article: Factors Associated with 28-day Critical Illness Development During the First Wave of COVID-19
Factors Associated with 28-day Critical Illness Development During the First Wave of COVID-19 Open
Objective: This study aimed to define the predictors of critical illness development within 28 days postadmission during the first wave of the COVID-19 pandemic. Materials and Methods: We conducted a prospective cohort study including 477 …
View article: A pilot study for treatment of severe COVID-19 pneumonia by aerosolized formulation of convalescent human immune plasma exosomes (ChipEXO™)
A pilot study for treatment of severe COVID-19 pneumonia by aerosolized formulation of convalescent human immune plasma exosomes (ChipEXO™) Open
This is a single-center prospective, open-label, single arm interventional study to test the safety and efficacy of recently described ChipEXO™ for severe COVID-19 pneumonia. The ChipEXO™ is a natural product derived from convalescent huma…
View article: Evaluation of the Diagnostic Value of Cell Population Data in Sepsis in Comparison to Localized Infection, Chronic Inflammation, and Noninfectious Inflammation Cases
Evaluation of the Diagnostic Value of Cell Population Data in Sepsis in Comparison to Localized Infection, Chronic Inflammation, and Noninfectious Inflammation Cases Open
Introduction Sepsis, defined as an increase of 2 points or more in the sequential organ failure assessment score, is a life-threatening organ dysfunction caused by the dysregulated host response to infection. Volume-conductivity-scatter (V…
View article: Cytokine Adsorption in Critically Ill COVID-19 Patients, a Case-Control Study
Cytokine Adsorption in Critically Ill COVID-19 Patients, a Case-Control Study Open
Aim: New coronavirus disease (COVID-19) has become an international emergency. As many of the intensive care unit (ICU) patients with the disease also present multiple organ failure, blood purification techniques might be a good choice in …
View article: Reduction of nosocomial infections in the intensive care unit using an electronic hand hygiene compliance monitoring system
Reduction of nosocomial infections in the intensive care unit using an electronic hand hygiene compliance monitoring system Open
Introduction: Healthcare-associated infection is an important cause of mortality and morbidity worldwide. Well-regulated infection control and hand hygiene are the most effective methods for preventing healthcare-associated infections. Thi…
View article: Policy Paper on Decision Making in Intensive Care Units
Policy Paper on Decision Making in Intensive Care Units Open
Intensive Care Units (ICU) are units where vital support with advanced technology is given to critically ill patients and multidisciplinary approaches are frequently applied. As we all see during the pandemic, the ICU beds are limited in n…
View article: Sarcopenic dysphagia following COVID‐19 infection: A new danger
Sarcopenic dysphagia following COVID‐19 infection: A new danger Open
Oropharyngeal dysphagia is one of the complications of endotracheal intubation. As expected, cases of dysphagia following coronavirus disease 2019 (COVID‐19) reported to date have all been intubated. We here report a case of sarcopenic dys…
View article: Impact of tocilizumab on clinical outcomes in severe covid-19 patients and risk of secondary infection: A case-control study
Impact of tocilizumab on clinical outcomes in severe covid-19 patients and risk of secondary infection: A case-control study Open
Objective: This study aimed to identify the effect of tocilizumab (TCZ) on clinical outcomes in severe COVID-19 patients. Material and Methods: We included hospitalized COVID-19 patients with an initial WHO scale ≥4. We matched the patient…
View article: Liver stiffness is associated with disease severity and worse clinical scenarios in coronavirus disease 2019: A prospective transient elastography study
Liver stiffness is associated with disease severity and worse clinical scenarios in coronavirus disease 2019: A prospective transient elastography study Open
Initial VCTE application might help physicians identify patients who are more likely to have severe illness or worse clinical outcomes, in addition to other well-established clinical and laboratory factors. Further multicentre prospective …
View article: An Outbreak Investigation of Burkholderia Cepacia Infections Related With Contaminated Chlorhexidine Mouthwash Solution in a Tertiary Care Center in Turkey.
An Outbreak Investigation of Burkholderia Cepacia Infections Related With Contaminated Chlorhexidine Mouthwash Solution in a Tertiary Care Center in Turkey. Open
Background: We report a nosocomial outbreak caused by Burkholderia cepacia that occurred among six patients admitted in the medical and surgical intensive care unit between 04 March 2019 and 02 April 2019 in Istanbul, Turkey. Methods: The …
View article: Factors associated with progression to critical illness in 28 days among COVID-19 patients: results from a tertiary care hospital in Istanbul, Turkey
Factors associated with progression to critical illness in 28 days among COVID-19 patients: results from a tertiary care hospital in Istanbul, Turkey Open
Background Coronavirus disease 2019 (COVID-19) quickly spread worldwide to become a pandemic. This study aimed to define the predictors of critical illness development within 28 days postadmission. Methods We conducted a prospective cohort…
View article: Consideration of Severe Coronavirus Disease 2019 As Viral Sepsis and Potential Use of Immune Checkpoint Inhibitors
Consideration of Severe Coronavirus Disease 2019 As Viral Sepsis and Potential Use of Immune Checkpoint Inhibitors Open
Taking into consideration the multisystemic clinical and autopsy findings in “severe” coronavirus disease 2019 patients, viral sepsis would be a more accurate term to describe the whole clinical picture. The most significant pathophysiolog…
View article: Dental follicle mesenchymal stem cells regulate responses in sepsis
Dental follicle mesenchymal stem cells regulate responses in sepsis Open
Objective: Sepsis-induced immune alterations are associated with secondary infections and increased risk of death. The use of mesenchymal stem cells (MSCs) has been described as a novel therapeutic strategy. We evaluated the immunomodulato…
View article: Primary Graft Dysfunction after Lung Transplantation
Primary Graft Dysfunction after Lung Transplantation Open
Primary graft dysfunction (PGD) is a severe form of acute lung injury that is a major cause of early morbidity and mortality encountered after lung transplantation. PGD is diagnosed by pulmonary oedema with diffuse alveolar damage that man…
View article: MSC Transplantation in Eight Severe COVID-19 Patients: Can Cytokine Storm Be Reversed?
MSC Transplantation in Eight Severe COVID-19 Patients: Can Cytokine Storm Be Reversed? Open
The COVID-19 disease is a global pandemic, with the first case diagnosed in December 2019, as reported by World Health Organization (WHO). In 17% of patients, COVID-19 causes severe Acute Respiratory Distress Syndrome (ARDS) due to release…
View article: A new scoring system for early diagnosis of ventilator-associated pneumonia: LUPPIS
A new scoring system for early diagnosis of ventilator-associated pneumonia: LUPPIS Open
LUPPIS appears to provide better results in the prediction of VAP compared to CPIS, and the importance of lung ultrasound and PTX-3 is emphasized, which is a distinctive property of LUPPIS.
View article: Serum vitamin D level variation in SIRS, sepsis and septic shock
Serum vitamin D level variation in SIRS, sepsis and septic shock Open
Objectives: Vitamin D has potent immunomodulatory effects with the capability of acting as an autocrine and paracrine agent,and inhibits inflammatory signaling. In this study, our aim was to evaluate the relationship between vitamin D leve…
View article: Renal Resistive Index is Unsusceptible to Systemic Hemodynamics in Fluid Responsive Critically Ill Patients
Renal Resistive Index is Unsusceptible to Systemic Hemodynamics in Fluid Responsive Critically Ill Patients Open
ÖZ Amaç: Kritik hastalarda sıvı resüsitasyonunun temel hedefi oksijen sunumunu artırarak organ perfüzyonunun sürdürülmesidir.Yoğun bakımda sıvı tedavisi renal monitorizasyon ilişkisi önemli olup, erken fazda sıvı tedavisine böbreğin yanıtı…
View article: Malnutrition, apoptosis, and autophagy triangle in critically ill patients
Malnutrition, apoptosis, and autophagy triangle in critically ill patients Open
Malnutrition is an important cause of mortality and morbidity in critically ill patients. Moreover, malnutrition leads to increased apoptosis leading to secondary immune deficiency. Nutritional support is therefore an important aspect of p…
View article: The Role of Transocular Ultrasound in the Assessment of Neurotoxicity-Related Encephalopathy in Mushroom Poisoning
The Role of Transocular Ultrasound in the Assessment of Neurotoxicity-Related Encephalopathy in Mushroom Poisoning Open
We detected increased ONSDs in patients with mushroom poisoning compared with those in the control healthy volunteers. Our findings suggest that ONSD, measured by ultrasonography, may be safely and effectively used to diagnose transient en…
View article: The Role of Transcranial Doppler Ultrasonography in the Diagnosis of Brain Death
The Role of Transcranial Doppler Ultrasonography in the Diagnosis of Brain Death Open
Ancillary tests can be used for the diagnosis of brain death in cases wherein uncertainty exists regarding the neurological examination and apnoea test cannot be performed. Transcranial Doppler ultrasonography (TCD) is a useful, valid, non…
View article: Current Statement of Intensive Care Units in Turkey: Data obtained from 67 Centers
Current Statement of Intensive Care Units in Turkey: Data obtained from 67 Centers Open
In terms of the number of staff, there is a need for specialist physicians, especially during the night and nurses in our country. It was thought that the number of ICU-certified nurses was comparatively sufficient, yet the target was supp…
View article: Sequential Measurements of Pentraxin 3 Serum Levels in Patients with Ventilator-Associated Pneumonia: A Nested Case-Control Study
Sequential Measurements of Pentraxin 3 Serum Levels in Patients with Ventilator-Associated Pneumonia: A Nested Case-Control Study Open
Purpose . The main purpose of this study was to investigate the dynamics of pentraxin 3 (PTX3) compared with procalcitonin (PCT) and C-reactive protein (CRP) in patients with suspicion of ventilator-associated pneumonia (VAP). Materials an…
View article: Diagnostic Accuracy of Procalcitonin for Differentiating Bacteraemic Gram-Negative Sepsis from Gram-Positive Sepsis
Diagnostic Accuracy of Procalcitonin for Differentiating Bacteraemic Gram-Negative Sepsis from Gram-Positive Sepsis Open
Patients with gram-negative sepsis had higher PCT values than those with gram-positive sepsis. Our results suggest that PCT value may be a useful tool for distinguishing between gram-negative and gram-positive bacteraemia.
View article: The Effect of Low Dose Sildenafil on Verapamil–Induced Cardiovascular Toxicity in Rats
The Effect of Low Dose Sildenafil on Verapamil–Induced Cardiovascular Toxicity in Rats Open
Experimental studies have shown that sildenafil may have significant cardio protective effects if used in low doses.The aim of this study was to compare the efficacies of glucagon and sildenafil treatments in anesthetized rats receiving ve…
View article: Changing Definitions of Sepsis
Changing Definitions of Sepsis Open
Sepsis is one of the main causes of morbidity and mortality in critically ill patients despite the use of modern antibiotics and resuscitation therapies. Outcomes in sepsis have improved overall, probably because of an enhanced focus on ea…