István Sebe
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View article: Development of Low-Dose Disulfiram Rectal Suppository Intended for Application in Post-Treatment Lyme Disease Syndrome
Development of Low-Dose Disulfiram Rectal Suppository Intended for Application in Post-Treatment Lyme Disease Syndrome Open
Background/Objectives: Early diagnosis and oral or, in severe cases, intravenous antibiotics are usually effective for Lyme disease, but some patients have persistent symptoms unresponsive to standards of care, requiring alternative therap…
View article: Cyclodextrin encapsulation enabling the anticancer repositioning of disulfiram: Preparation, analytical and in vitro biological characterization of the inclusion complexes
Cyclodextrin encapsulation enabling the anticancer repositioning of disulfiram: Preparation, analytical and in vitro biological characterization of the inclusion complexes Open
Drug repositioning is a high-priority and feasible strategy in the field of oncology research, where the unmet medical needs are continuously unbalanced. Disulfiram is a potential non-chemotherapeutic, adjuvant anticancer agent. However, t…
View article: Positron Annihilation Lifetime Spectroscopy as a Special Technique for the Solid-State Characterization of Pharmaceutical Excipients, Drug Delivery Systems, and Medical Devices—A Systematic Review
Positron Annihilation Lifetime Spectroscopy as a Special Technique for the Solid-State Characterization of Pharmaceutical Excipients, Drug Delivery Systems, and Medical Devices—A Systematic Review Open
The aims of this systematic review are to explore the possibilities of using the positron annihilation lifetime spectroscopy (PALS) method in the pharmaceutical industry and to examine the application of PALS as a supportive, predictive me…
View article: Insulin for topical use in wound healing: opportunities and limitations
Insulin for topical use in wound healing: opportunities and limitations Open
Aims: The role of insulin in the regulation of energy metabolism, protein synthesis, proliferation, migration, secretion by keratinocytes, endothelial cells, and fibroblasts suggests that its presence is essential for wound healing (WH). T…
View article: Novel modified vertical diffusion cell for testing of in vitro drug release (IVRT) of topical patches
Novel modified vertical diffusion cell for testing of in vitro drug release (IVRT) of topical patches Open
The vertical diffusion cell is an in vitro laboratory device for the study of drug release and permeation of semi-solid topical formulations and topical patches. Both static and dynamic versions of the diffusion cell are used in practice, …
View article: Fire safety design of pressure vessels
Fire safety design of pressure vessels Open
A calculation of welded pressure vessels for fire safety is shown in this paper. At the first step, the temperature of the steel walls has been investigated, and the inner liquid pressure and the temperature increase. It is assumed that th…
View article: Design of the Prototype of Contact Drawing Device for Potential Individual Therapeutic Fiber Formation Purposes
Design of the Prototype of Contact Drawing Device for Potential Individual Therapeutic Fiber Formation Purposes Open
Pharmaceutical compounding enables the preparation of unlicensed medicine to meet specific patient needs that do not have a licensed medicine available on the market. It must be performed in the best possible circumstance by certified phar…
View article: Scale-up of Electrospinning: Market Overview of Products and Devices for Pharmaceutical and Biomedical Purposes
Scale-up of Electrospinning: Market Overview of Products and Devices for Pharmaceutical and Biomedical Purposes Open
Recently, the electrospinning (ES) process has been extensively studied due to its potential applications in various fields, particularly pharmaceutical and biomedical purposes. The production rate using typical ES technology is usually ar…
View article: Effects of Sucrose Palmitate on the Physico-Chemical and Mucoadhesive Properties of Buccal Films
Effects of Sucrose Palmitate on the Physico-Chemical and Mucoadhesive Properties of Buccal Films Open
In our current research, sucrose palmitate (SP) was applied as a possible permeation enhancer for buccal use. This route of administration is a novelty as there is no literature on the use of SP in buccal mucoadhesive films. Films containi…
View article: Recent Development of Electrospinning for Drug Delivery
Recent Development of Electrospinning for Drug Delivery Open
Several promising techniques have been developed to overcome the poor solubility and/or membrane permeability properties of new drug candidates, including different fiber formation methods. Electrospinning is one of the most commonly used …
View article: Recent Development of Electrospinning for Drug Delivery
Recent Development of Electrospinning for Drug Delivery Open
Electrospinning is one of the most widely used techniques for the fabrication of nano/microparticles and nano/microfibers, induced by a high voltage applied to the drug-loaded solution [...]
View article: Optimum Design of Vessel Supporting Frame for Fire
Optimum Design of Vessel Supporting Frame for Fire Open
This article deals with the optimization of a vessel supporting frame for fire.A structure is economical, if its mass is the smallest as possible.Mass optimization with and without fire protection are discussed.Nowadays a lot of fire prote…