Isuru Ranasinghe
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View article: National trends in stroke hospitalisations, mortality, and recurrent stroke in Australia and New Zealand
National trends in stroke hospitalisations, mortality, and recurrent stroke in Australia and New Zealand Open
Robust data on trends in stroke hospitalisation rate and outcomes are needed to improve stroke care, yet are sparse and show conflicting results. We investigated the trends in hospitalisation rate, survival, and risk of stroke recurrence f…
View article: Timing, Diagnosis, and Potential Preventability of 30-Day Unplanned Readmissions After a Heart Failure Hospitalisation: Implications for Care Quality
Timing, Diagnosis, and Potential Preventability of 30-Day Unplanned Readmissions After a Heart Failure Hospitalisation: Implications for Care Quality Open
The peak risk of unplanned readmission occurred in the first few days after discharge, often for potentially preventable reasons such as hospital-acquired complications and recurrent heart failure. Such early and potentially preventable re…
View article: Incidence, timing and variation in unplanned readmissions within 30-days following isolated coronary artery bypass grafting
Incidence, timing and variation in unplanned readmissions within 30-days following isolated coronary artery bypass grafting Open
One-in-8 patients undergoing CABG experienced an unplanned readmission within 30-day, rising to one-in-6 following urgent CABG. There was little statistically significant institutional variation in RSRR. Nevertheless, many readmissions are…
View article: Hospital costs for unplanned re‐admissions within 30 days of hospitalisations with heart failure, Australia, 2013–2017: a retrospective cohort study
Hospital costs for unplanned re‐admissions within 30 days of hospitalisations with heart failure, Australia, 2013–2017: a retrospective cohort study Open
Objectives To assess the direct hospital costs for unplanned re‐admissions within 30 days of hospitalisations with heart failure in Australia; to estimate the proportion of these costs attributable to potentially preventable re‐admissions.…
View article: Clinical characteristics and outcomes of Australian and Indian ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI)
Clinical characteristics and outcomes of Australian and Indian ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI) Open
Significant differences in demographics and presentation characteristics exist between Indian and Australian STEMI patients treated with pPCI. Indian patients had significantly longer pre-hospital delays and lower achievement of TIMI III f…
View article: Long-term outcomes after hospitalization for atrial fibrillation or flutter
Long-term outcomes after hospitalization for atrial fibrillation or flutter Open
Background and Aims Atrial fibrillation (AF) and flutter are common causes of hospitalizations but contemporary long-term outcomes following these episodes are uncertain. This study assessed outcomes up to 10 years after an acute AF or flu…
View article: Excess Bed Days and Hospitalization Costs Associated With 30‐Day Complications Following Catheter Ablation of Atrial Fibrillation
Excess Bed Days and Hospitalization Costs Associated With 30‐Day Complications Following Catheter Ablation of Atrial Fibrillation Open
Background The incidence and type of complications following catheter ablation of atrial fibrillation have been extensively examined, but the impact associated with these complications on the length of stay and hospitalization costs is unk…
View article: Pericardial infiltration and constriction due to cardiac actinomycosis—case report
Pericardial infiltration and constriction due to cardiac actinomycosis—case report Open
Background Constrictive pericarditis associated with actinomycosis infection is a rare and challenging diagnosis due to its insidious manifestation. We describe the successful treatment of pericardial infiltration and constriction due to a…
View article: Prehospital Activation of the Cardiac Catheterization Laboratory in ST‐Segment–Elevation Myocardial Infarction for Primary Percutaneous Coronary Intervention
Prehospital Activation of the Cardiac Catheterization Laboratory in ST‐Segment–Elevation Myocardial Infarction for Primary Percutaneous Coronary Intervention Open
Background Prehospital activation of the cardiac catheter laboratory is associated with significant improvements in ST‐segment–elevation myocardial infarction (STEMI) performance measures. However, there are equivocal data, particularly wi…
View article: Potentially Preventable Health Care Costs Associated With Unplanned 30-day Readmissions Following Hospitalisation for Heart Failure
Potentially Preventable Health Care Costs Associated With Unplanned 30-day Readmissions Following Hospitalisation for Heart Failure Open
View article: Regional Differences in ST-Segment Elevation Myocardial Infarction (STEMI) Treatment and Outcomes in Queensland
Regional Differences in ST-Segment Elevation Myocardial Infarction (STEMI) Treatment and Outcomes in Queensland Open
View article: Freedom from atrial arrhythmia and other clinical outcomes at 5 years and beyond after catheter ablation of atrial fibrillation: a systematic review and meta-analysis
Freedom from atrial arrhythmia and other clinical outcomes at 5 years and beyond after catheter ablation of atrial fibrillation: a systematic review and meta-analysis Open
Aims Catheter ablation of atrial fibrillation (AF) is now a mainstream procedure although long-term outcomes are uncertain. We performed a systematic review and meta-analysis of procedural outcomes at 5 years and beyond. Methods and result…
View article: Prehospital activation of the cardiac catheterisation laboratory in ST-segment elevation myocardial infarction (STEMI) for primary percutaneous coronary intervention (PCI)
Prehospital activation of the cardiac catheterisation laboratory in ST-segment elevation myocardial infarction (STEMI) for primary percutaneous coronary intervention (PCI) Open
Background Prehospital activation of the cardiac catheter laboratory is associated with significant improvements in ST-segment elevation myocardial infarction (STEMI) performance measures. However, there is equivocal data, particularly wit…
View article: Personalized diagnosis in suspected myocardial infarction
Personalized diagnosis in suspected myocardial infarction Open
Background In suspected myocardial infarction (MI), guidelines recommend using high-sensitivity cardiac troponin (hs-cTn)-based approaches. These require fixed assay-specific thresholds and timepoints, without directly integrating clinical…
View article: The Prognostic Value of Echocardiographic Wall Motion Score Index in ST-Segment Elevation Myocardial Infarction
The Prognostic Value of Echocardiographic Wall Motion Score Index in ST-Segment Elevation Myocardial Infarction Open
Background. When compared to left ventricular ejection fraction (LVEF), previous studies have suggested the superiority of wall motion score index (WMSI) in predicting cardiac events in patients who have suffered acute myocardial infarctio…
View article: Single High-Sensitivity Point-of-Care Whole-Blood Cardiac Troponin I Measurement to Rule Out Acute Myocardial Infarction at Low Risk
Single High-Sensitivity Point-of-Care Whole-Blood Cardiac Troponin I Measurement to Rule Out Acute Myocardial Infarction at Low Risk Open
Background: High-sensitivity cardiac troponin (hs-cTn) laboratory assays are used to rule out myocardial infarction (MI) on presentation, but prolonged result turnaround times can delay patient management. Our primary aim was to identify p…
View article: Novel Pulmonary Delivery of Drugs for the Management of Atrial Fibrillation
Novel Pulmonary Delivery of Drugs for the Management of Atrial Fibrillation Open
View article: Very long-term outcomes of patients undergoing catheter ablation of atrial fibrillation: a systematic review and meta-analysis
Very long-term outcomes of patients undergoing catheter ablation of atrial fibrillation: a systematic review and meta-analysis Open
Background The efficacy of catheter ablation of atrial fibrillation (AF) is reported to stabilise at 5-year, but most studies report up to 3-year-outcomes only. Objective To perform a systematic review and meta-analysis of outcomes at 5-ye…
View article: Sex differences in time to primary percutaneous coronary intervention and outcomes in patients presenting with ST‐segment elevation myocardial infarction
Sex differences in time to primary percutaneous coronary intervention and outcomes in patients presenting with ST‐segment elevation myocardial infarction Open
Objectives We assessed sex differences in treatment and outcomes in ST‐segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI). Background Historically, delays to timely reperf…
View article: Long‐term survival and life expectancy following an acute heart failure hospitalization in Australia and New Zealand
Long‐term survival and life expectancy following an acute heart failure hospitalization in Australia and New Zealand Open
Aims Contemporary long‐term survival following a heart failure (HF) hospitalization is uncertain. We evaluated survival up to 10 years after a HF hospitalization using national data from Australia and New Zealand, identified predictors of …
View article: Longitudinal risk of death, hospitalizations for atrial fibrillation, and cardiovascular events following catheter ablation of atrial fibrillation: a cohort study
Longitudinal risk of death, hospitalizations for atrial fibrillation, and cardiovascular events following catheter ablation of atrial fibrillation: a cohort study Open
Aims Population studies reporting contemporary long-term outcomes following catheter ablation of atrial fibrillation (AF) are sparse. We evaluated long-term clinical outcomes following AF ablation and examined variation in outcomes by age,…
View article: Long-Term Survival, Stroke Recurrence, and Life Expectancy After an Acute Stroke in Australia and New Zealand From 2008–2017: A Population-Wide Cohort Study
Long-Term Survival, Stroke Recurrence, and Life Expectancy After an Acute Stroke in Australia and New Zealand From 2008–2017: A Population-Wide Cohort Study Open
Background: Data on long-term outcomes following an acute stroke are sparse. We assessed survival, risk of recurrent stroke and loss in life expectancy following an acute stroke using population-wide data from Australia and New Zealand. Me…
View article: Association of hypertension with mortality in patients hospitalised with COVID-19
Association of hypertension with mortality in patients hospitalised with COVID-19 Open
Objective To assess whether hypertension is an independent risk factor for mortality among patients hospitalised with COVID-19, and to evaluate the impact of ACE inhibitor and angiotensin receptor blocker (ARB) use on mortality in patients…
View article: Incidence and causes of early unplanned readmission after hospitalisation with peripheral arterial disease in Australia and New Zealand
Incidence and causes of early unplanned readmission after hospitalisation with peripheral arterial disease in Australia and New Zealand Open
Unplanned readmissions within 30 days of hospitalisation for PAD are often for potentially preventable reasons. Their number should be reduced to improve clinical outcomes for people with PAD.
View article: Cardiac Complications in Patients Hospitalised With COVID-19 in Australia
Cardiac Complications in Patients Hospitalised With COVID-19 in Australia Open
View article: Utilisation and safety of catheter ablation of atrial fibrillation in public and private sector hospitals
Utilisation and safety of catheter ablation of atrial fibrillation in public and private sector hospitals Open
Background Little is known about the utilisation and safety of catheter ablation of atrial fibrillation (AF) among public and private sector hospitals. Aims To examine the uptake of AF ablations and compare procedural safety between the se…
View article: The incidence of cardiac complications in patients hospitalised with COVID‐19 in Australia: the AUS‐COVID study
The incidence of cardiac complications in patients hospitalised with COVID‐19 in Australia: the AUS‐COVID study Open
Recognised cardiac complications of coronavirus disease 2019 (COVID-19) include arrhythmias,1, 2 myopericarditis,3 and cardiomyopathy,4, 5 but data on their incidence are limited. The Australian Cardiovascular COVID-19 Registry (AUS-COVID)…
View article: Unplanned hospital visits after ambulatory surgical care
Unplanned hospital visits after ambulatory surgical care Open
Objectives We sought to assess the rate of unplanned hospital visits among patients undergoing ambulatory surgery. Summary background data The majority of surgeries performed in the United States now take place in outpatient settings. Post…
View article: Safety and Efficacy of Leadless Pacemakers: A Systematic Review and Meta‐Analysis
Safety and Efficacy of Leadless Pacemakers: A Systematic Review and Meta‐Analysis Open
Background Leadless pacemaker is a novel technology, and evidence supporting its use is uncertain. We performed a systematic review and meta‐analysis to examine the safety and efficacy of leadless pacemakers implanted in the right ventricl…
View article: P298 Budesonide MMX versus Prednisolone for Ulcerative Colitis: Comparative outcomes from a British retrospective multi-centre study
P298 Budesonide MMX versus Prednisolone for Ulcerative Colitis: Comparative outcomes from a British retrospective multi-centre study Open
Background Budesonide MMX (Cortiment) is superior to placebo for mild to moderate UC flares and has a favourable side effect profile. However, no head-to-head data with Prednisolone exist. During the COVID-19 pandemic many IBD units chose …