Itai Sharon
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View article: Pear flower and leaf microbiome dynamics during the naturally occurring spread of <i>Erwinia amylovora</i>
Pear flower and leaf microbiome dynamics during the naturally occurring spread of <i>Erwinia amylovora</i> Open
Erwinia amylovora is the causal pathogen of fire blight, a contagious disease that affects apple and pear trees and other members of the family Rosaceae. In this study, we investigated the community dynamics of the pear flower microbiome i…
View article: Rubisco is slow across the tree of life
Rubisco is slow across the tree of life Open
Rubisco is the main gateway through which inorganic carbon enters the biosphere, catalyzing the vast majority of carbon fixation on Earth. This pivotal enzyme has long been observed to be kinetically constrained. Yet, this impression is ba…
View article: Author response: A metabolic modeling-based framework for predicting trophic dependencies in native rhizobiomes of crop plants
Author response: A metabolic modeling-based framework for predicting trophic dependencies in native rhizobiomes of crop plants Open
View article: A metabolic modeling-based framework for predicting trophic dependencies in native rhizobiomes of crop plants
A metabolic modeling-based framework for predicting trophic dependencies in native rhizobiomes of crop plants Open
The exchange of metabolites (i.e., metabolic interactions) between bacteria in the rhizosphere determines various plant-associated functions. Systematically understanding the metabolic interactions in the rhizosphere, as well as in other t…
View article: Author response: A metabolic modeling-based framework for predicting trophic dependencies in native rhizobiomes of crop plants
Author response: A metabolic modeling-based framework for predicting trophic dependencies in native rhizobiomes of crop plants Open
View article: A metabolic modeling-based framework for predicting trophic dependencies in native rhizobiomes of crop plants
A metabolic modeling-based framework for predicting trophic dependencies in native rhizobiomes of crop plants Open
The exchange of metabolites (i.e., metabolic interactions) between bacteria in the rhizosphere determines various plant-associated functions. Systematically understanding the metabolic interactions in the rhizosphere, as well as in other t…
View article: A systematic exploration of bacterial form I rubisco maximal carboxylation rates
A systematic exploration of bacterial form I rubisco maximal carboxylation rates Open
View article: A metabolic modeling-based framework for predicting trophic dependencies in native rhizobiomes of crop plants
A metabolic modeling-based framework for predicting trophic dependencies in native rhizobiomes of crop plants Open
The exchange of metabolites (i.e., metabolic interactions) between bacteria in the rhizosphere determines various plant-associated functions. Systematically understanding the metabolic interactions in the rhizosphere, as well as in other t…
View article: Author Response: A metabolic modeling-based framework for predicting trophic dependencies in native rhizobiomes of crop plants
Author Response: A metabolic modeling-based framework for predicting trophic dependencies in native rhizobiomes of crop plants Open
View article: A metabolic modeling-based framework for predicting trophic dependencies in native rhizobiomes of crop plants
A metabolic modeling-based framework for predicting trophic dependencies in native rhizobiomes of crop plants Open
The exchange of metabolites (i.e., metabolic interactions) between bacteria in the rhizosphere determines various plant-associated functions. Systematically understanding the metabolic interactions in the rhizosphere, as well as in other t…
View article: Reviewer #2 (Public Review): A metabolic modeling-based framework for predicting trophic dependencies in native rhizobiomes of crop plants
Reviewer #2 (Public Review): A metabolic modeling-based framework for predicting trophic dependencies in native rhizobiomes of crop plants Open
The exchange of metabolites (i.e., metabolic interactions) between bacteria in the rhizosphere determines various plant-associated functions. Systematically understanding the metabolic interactions in the rhizosphere, as well as in other t…
View article: Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota
Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota Open
View article: Pear flower and leaf microbiome dynamics during the naturally occurring spread of<i>Erwinia amylovora</i>
Pear flower and leaf microbiome dynamics during the naturally occurring spread of<i>Erwinia amylovora</i> Open
Erwinia amylovora is the causal pathogen of fire blight, a contagious disease that affects apple and pear trees and other members of the family Rosaceae. In this study, we investigated the population dynamics of the pear flower microbiome …
View article: A metabolic modeling-based framework for predicting trophic dependencies in native rhizobiomes of crop plants
A metabolic modeling-based framework for predicting trophic dependencies in native rhizobiomes of crop plants Open
The exchange of metabolites (i.e., metabolic interactions) between bacteria in the rhizosphere determines various plant-associated functions. Systematically understanding the metabolic interactions in the rhizosphere, as well as in other t…
View article: Systematic exploration of bacterial form I rubisco maximal carboxylation rates
Systematic exploration of bacterial form I rubisco maximal carboxylation rates Open
Autotrophy is the basis for complex life on Earth. Central to this process is rubisco - the enzyme that catalyzes almost all carbon fixation on the planet. Yet, with only a small fraction of rubisco diversity kinetically characterized so f…
View article: Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota
Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota Open
Summary Reversible genomic DNA-inversions control expression of numerous bacterial molecules in the human gut, but how this relates to disease remains uncertain. By analyzing metagenomic samples from six human Inflammatory Bowel Disease co…
View article: Genomic sequences for the 9,530 MAGs in the 953-species dataset
Genomic sequences for the 9,530 MAGs in the 953-species dataset Open
This dataset contains the genomic sequences for the 9,530 MAGs used in the paper "Using lossless compression algorithms to improve metagenomics binning and accelerate genome taxonomic classification" by Meir et al., 2024.MAGs in this datas…
View article: The Core Human Microbiome: Does It Exist and How Can We Find It? A Critical Review of the Concept
The Core Human Microbiome: Does It Exist and How Can We Find It? A Critical Review of the Concept Open
The core microbiome, which refers to a set of consistent microbial features across populations, is of major interest in microbiome research and has been addressed by numerous studies. Understanding the core microbiome can help identify ele…
View article: HDHL-INTIMIC: A European Knowledge Platform on Food, Diet, Intestinal Microbiomics, and Human Health
HDHL-INTIMIC: A European Knowledge Platform on Food, Diet, Intestinal Microbiomics, and Human Health Open
Studies indicate that the intestinal microbiota influences general metabolic processes in humans, thereby modulating the risk of chronic diseases such as type 2 diabetes, allergy, cardiovascular disease, and colorectal cancer (CRC). Dietar…
View article: Mining Marine Metagenomes Revealed a Quorum-Quenching Lactonase with Improved Biochemical Properties That Inhibits the Food Spoilage Bacterium Pseudomonas fluorescens
Mining Marine Metagenomes Revealed a Quorum-Quenching Lactonase with Improved Biochemical Properties That Inhibits the Food Spoilage Bacterium Pseudomonas fluorescens Open
Our results emphasize the potential of sequence and structure-based identification of new QQ enzymes from environmental metagenomes, such as from the ocean, with improved stability or activity. The findings also suggest that purified QQ en…
View article: Origins of bloodstream infections following fecal microbiota transplantation: a strain-level analysis
Origins of bloodstream infections following fecal microbiota transplantation: a strain-level analysis Open
We observed high rates of bloodstream infections (BSIs) following fecal microbiota transplantation (FMT) for graft-versus-host-disease (33 events in 22 patients). To trace the BSIs' origin, we applied a metagenomic bioinformatic pipeline s…
View article: Design, Synthesis and Biological Evaluation of Novel SARS-CoV-2 3CLpro Covalent Inhibitors
Design, Synthesis and Biological Evaluation of Novel SARS-CoV-2 3CLpro Covalent Inhibitors Open
Severe diseases such as the ongoing COVID-19 pandemic, as well as the previous SARS and MERS outbreaks, are the result of coronavirus infections and have demonstrated the urgent need for antiviral drugs to combat these deadly viruses. Due …
View article: Neonatal antibiotic exposure impairs child growth during the first six years of life by perturbing intestinal microbial colonization
Neonatal antibiotic exposure impairs child growth during the first six years of life by perturbing intestinal microbial colonization Open
Exposure to antibiotics in the first days of life is thought to affect various physiological aspects of neonatal development. Here, we investigate the long-term impact of antibiotic treatment in the neonatal period and early childhood on c…
View article: Design, Synthesis and Biological Evaluation of Novel SARS-CoV-2 3CLpro Covalent Inhibitors
Design, Synthesis and Biological Evaluation of Novel SARS-CoV-2 3CLpro Covalent Inhibitors Open
Severe diseases such as the ongoing COVID-19 pandemic, as well as the previous SARS and MERS outbreaks, are the result of coronavirus infections and have demonstrated the urgent need for antiviral drugs to combat these deadly viruses. Due …
View article: Highly active rubiscos discovered by systematic interrogation of natural sequence diversity
Highly active rubiscos discovered by systematic interrogation of natural sequence diversity Open
View article: A novel uncultured marine cyanophage lineage with lysogenic potential linked to a putative marine <i>Synechococcus</i> ‘relic’ prophage
A novel uncultured marine cyanophage lineage with lysogenic potential linked to a putative marine <i>Synechococcus</i> ‘relic’ prophage Open
Summary Marine cyanobacteria are important contributors to primary production in the ocean and their viruses (cyanophages) affect the ocean microbial communities. Despite reports of lysogeny in marine cyanobacteria, a genome sequence of su…
View article: Author Correction: Hydrogen-based metabolism as an ancestral trait in lineages sibling to the Cyanobacteria
Author Correction: Hydrogen-based metabolism as an ancestral trait in lineages sibling to the Cyanobacteria Open
The original version of this Article contained errors in Fig. 4. In panel a, the labels ‘F420-reducing NiFe hydrogenase (group 3a)’ and ‘Group 2 NiFe hydrogenase’ were misplaced. These errors have been corrected in both the PDF and HTML ve…
View article: Hydrogen-based metabolism as an ancestral trait in lineages sibling to the Cyanobacteria
Hydrogen-based metabolism as an ancestral trait in lineages sibling to the Cyanobacteria Open
View article: Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT
Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT Open
View article: Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features
Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features Open