Itai Strominger
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View article: Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes
Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes Open
Single-cell analysis of CD4 T cells reveals a population structure associated with inflammation and declined immunity in aging.
View article: CD4 T Cells Induce A Subset of MHCII-Expressing Microglia that Attenuates Alzheimer Pathology
CD4 T Cells Induce A Subset of MHCII-Expressing Microglia that Attenuates Alzheimer Pathology Open
Microglia play a key role in innate immunity in Alzheimer disease (AD), but their role as antigen-presenting cells is as yet unclear. Here we found that amyloid β peptide (Aβ)-specific T helper 1 (Aβ-Th1 cells) T cells polarized to secrete…
View article: The Choroid Plexus Functions as a Niche for T-Cell Stimulation Within the Central Nervous System
The Choroid Plexus Functions as a Niche for T-Cell Stimulation Within the Central Nervous System Open
The choroid plexus (CP) compartment in the ventricles of the brain comprises fenestrated vasculature and, therefore, it is permeable to blood-borne mediators of inflammation. Here, we explored whether T-cell activation in the CP plays a ro…
View article: Old Mice Accumulate Activated Effector CD4 T Cells Refractory to Regulatory T Cell-Induced Immunosuppression
Old Mice Accumulate Activated Effector CD4 T Cells Refractory to Regulatory T Cell-Induced Immunosuppression Open
Chronic low-grade inflammation and reduced lymphocyte potency are implicated in the pathogenesis of major illnesses associated with aging. Whether this immune phenotype results from a loss of cell-mediated regulation or intrinsic dysregula…