Explanipedia

Dopamine release effects on striatal blood oxygenation and whole brain plasticity underlying associative learning Open

Amir Lawen, Isabella Succi, Daniela Lichtman, Darcy S. Peterka, Ishmail Abdus-Saboor , et al. · 2025

Dopaminergic signaling in the nucleus accumbens (NAc) is central to reward-based learning, but its relationship to brain-wide hemodynamics remains unclear. Using concurrent fMRI and dopamine photometry in awake, behaving mice, we reveal th…

Charting the path in rodent functional neuroimaging Open

Alessandro Gozzi, Alexia Stuefer, Filomena Grazia Alvino, Valeria Bedin, Christopher G. Cover , et al. · 2025

Driven by a period of accelerated progress and recent technical breakthroughs, whole-brain functional neuroimaging in rodents offers exciting new possibilities for addressing basic questions about brain function and its alterations. In res…

Striatal and hippocampal contributions to instrumental learning in the mouse using high-resolution behavioral monitoring and fMRI Open

Eyal Bergmann, Daniela Lichtman, Admir Resulaj, Guy Yona, Ornit Nahman , et al. · 2025

The mammalian brain orchestrates goal-directed behavior through complex interactions between multiple memory systems, with the striatum and hippocampus playing pivotal interrelated roles. A central open question is the extent to which dist…

Early basal ganglia imaging abnormalities in pre‐symptomatic and early symptomatic novel APP duplication carriers Open

Rotem Paz, Eyal Bergmann, Ayelet Eran, Yael Rozen, Sapir Golan , et al. · 2024

Background We aim to describe the imaging findings in pre‐symptomatic and early‐symptomatic individuals carrying a recently described novel APP duplication rearrangement causing early‐onset AD (EOAD). Method We studied individuals from one…

Leveraging genetic diversity in mice to inform individual differences in brain microstructure and memory Open

Thomas J. Murdy, Amy R. Dunn, Surjeet Singh, Maria A. Telpoukhovskaia, Shanrong Zhang , et al. · 2023

In human Alzheimer’s disease (AD) patients and AD mouse models, both differential pre-disease brain features and differential disease-associated memory decline are observed, suggesting that certain neurological features may protect against…

Brain Connectivity Predicts Chronic Pain in Acute Mild Traumatic Brain Injury Open

Noam Bosak, Paulo Branco, Pora Kuperman, Chen Buxbaum, Ruth Manor Cohen , et al. · 2022

Objectives Previous studies have established the role of the cortico‐mesolimbic and descending pain modulation systems in chronic pain prediction. Mild traumatic brain injury (mTBI) is an acute pain model where chronic pain is prevalent an…

The default network is causally linked to creative thinking Open

Ben Shofty, Tal Gonen, Eyal Bergmann, Naama Mayseless, Akiva Korn , et al. · 2022

Creative thinking represents a major evolutionary mechanism that greatly contributed to the rapid advancement of the human species. The ability to produce novel and useful ideas, or original thinking, is thought to correlate well with unex…

Functional MRI of the Behaving Mouse with High-Resolution Behavioral Monitoring Open

Eyal Bergmann, Admir Resulaj, Daniela Lichtman, Guy Yona, Ornit Nahman , et al. · 2022

Structural brain connectivity predicts acute pain after mild traumatic brain injury Open

Paulo Branco, Noam Bosak, Jannis Bielefeld, Olivia Cong, Yelena Granovsky , et al. · 2021

Mild traumatic brain injury, mTBI, is a leading cause of disability worldwide, with acute pain manifesting as one of its most debilitating symptoms. Understanding acute post-injury pain is important since it is a strong predictor of long-t…

Structural and functional brain-wide alterations in A350V Iqsec2 mutant mice displaying autistic-like behavior Open

Daniela Lichtman, Eyal Bergmann, Alexandra Kavushansky, Nadav Cohen, Nina S. Levy , et al. · 2021

IQSEC2 is an X-linked gene that is associated with autism spectrum disorder (ASD), intellectual disability, and epilepsy. IQSEC2 is a postsynaptic density protein, localized on excitatory synapses as part of the NMDA receptor complex and i…

Individual variability in functional connectivity architecture of the mouse brain Open

Eyal Bergmann, Xenia Gofman, Alexandra Kavushansky, Itamar Kahn · 2020

In recent years precision fMRI has emerged in human brain research, demonstrating characterization of individual differences in brain organization. However, mechanistic investigations to the sources of individual variability are limited in…

Structural and Functional Brain-wide Alterations in A350V IQSEC2 Mutant Mice Displaying Autistic-like Behavior Open

Daniela Lichtman, Eyal Bergmann, Alexandra Kavushansky, Nadav Cohen, Nina S. Levy , et al. · 2020

IQSEC2 is an X-linked gene which is associated with autism spectrum disorder (ASD), intellectual disability and epilepsy. IQSEC2 is a postsynaptic density protein, localized on excitatory synapses as part of the NMDA receptor complex and i…

Brain-wide structural and functional disruption in mice with oligodendrocyte-specific Nf1 deletion is rescued by inhibition of nitric oxide synthase Open

Jad Asleh, Ben Shofty, Nadav Cohen, Alexandra Kavushansky, Alejandro López‐Juárez , et al. · 2020

Significance This study assessed the effects of myelin decompaction on motor behavior and brain-wide structural and functional connectivity, and the effect of nitric oxide synthase inhibition by N -nitro- l -arginine methyl ester (L-NAME) …

Brain-wide structural and functional disruption in mice with oligodendrocyte specificNf1deletion is rescued by inhibition of NOS Open

Jad Asleh, Ben Shofty, Nadav Cohen, Alexandra Kavushansky, Alejandro López‐Juárez , et al. · 2020

Neurofibromin gene ( NF1 ) mutation causes Neurofibromatosis type 1 (NF1), a disorder in which brain white matter deficits identified by neuroimaging are common, yet of unknown cellular etiology. In mice, Nf1 loss in adult oligodendrocyte …

Individual variability in functional connectivity architecture of the mouse brain Open

Eyal Bergmann, Xenia Gofman, Alexandra Kavushansky, Itamar Kahn · 2020

The functional organization of brain networks can be estimated using fMRI by examining the coherence of spontaneous fluctuations in the fMRI signal, a method known as resting-state functional connectivity MRI. Previous studies in humans re…

Individual structural features constrain the mouse functional connectome Open

Francesca Melozzi, Eyal Bergmann, Julie A. Harris, Itamar Kahn, Viktor Jirsa , et al. · 2019

Whole brain dynamics intuitively depend upon the internal wiring of the brain; but to which extent the individual structural connectome constrains the corresponding functional connectome is unknown, even though its importance is unconteste…

Autism-associated Nf1 deficiency disrupts corticocortical and corticostriatal functional connectivity in human and mouse Open

Ben Shofty, Eyal Bergmann, Gil Zur, Jad Asleh, Noam Bosak , et al. · 2019

Structural integrity following focused ultrasound thalamotomy and its correlation with tremor relief Open

Gil Zur, Orit H. Lesman‐Segev, Ilana Schlesinger, Dorith Goldsher, Alon Sinai , et al. · 2019

Background Magnetic-resonance-guided focused ultrasound ablation of ventral intermediate nucleus of the thalamus is a new treatment for tremor disorders. Objectives We sought to evaluate the white matter integrity prior to and following fo…

Loss of function in the autism and learning disabilities associated gene Nf1 disrupts corticocortical and corticostriatal functional connectivity in human and mouse Open

Ben Shofty, Eyal Bergmann, Gil Zur, Jad Asleh, Noam Bosak , et al. · 2019

Children with the autosomal dominant single gene disorder, neurofibromatosis type 1 (NF1), display multiple structural and functional changes in the central nervous system, resulting in neuropsychological cognitive abnormalities. Here we a…

Individual structural features constrain the mouse functional connectome Open

Francesca Melozzi, Eyal Bergmann, Julie A. Harris, Itamar Kahn, Viktor Jirsa , et al. · 2019

Whole brain dynamics intuitively depends upon the internal wiring of the brain; but to which extent the individual structural connectome constrains the corresponding functional connectome is unknown, even though its importance is uncontest…

An IQSEC2 Mutation Associated With Intellectual Disability and Autism Results in Decreased Surface AMPA Receptors Open

Eli Rogers, Reem Jada, Kinneret Schragenheim-Rozales, Megha Sah, Marisol Cortés , et al. · 2019

We have recently described an A350V mutation in IQSEC2 associated with intellectual disability, autism and epilepsy. We sought to understand the molecular pathophysiology of this mutation with the goal of developing targets for drug interv…

Multi-Modal Nano Particle Labeling of Neurons Open

Lilac Amirav, Shai Berlin, Shunit Olszakier, Sandip Kumar Pahari, Itamar Kahn · 2019

The development of imaging methodologies for single cell measurements over extended timescales of up to weeks, in the intact animal, will depend on signal strength, stability, validity and specificity of labeling. Whereas light-microscopy …

P2‐489: CHARACTERIZING COGNITIVE AND NEURAL ALTERATIONS AMONG HEALTHY PARTICIPANTS WITH A GENETIC PREDISPOSITION FOR ALZHEIMER'S DISEASE Open

Rotem Paz, Tzipora C. Falik‐Zaccai, Judith Aharon‐Peretz, Itamar Kahn · 2018

Detecting subtle alterations among genetically at risk population for developing Alzheimer's Disease (AD), in presymptomatic stages will open a time window for intervention and prevention. It is now acknowledged that in order to arrest or …

Utah optrode array customization using stereotactic brain atlases and 3-D CAD modeling for optogenetic neocortical interrogation in small rodents and nonhuman primates Open

Ronald W. Boutte, Sam Merlin, Guy Yona, Brandon Griffiths, Alessandra Angelucci , et al. · 2017

As the optogenetic field expands, the need for precise targeting of neocortical circuits only grows more crucial. This work demonstrates a technique for using Solidworks^® computer-aided design (CAD) and readily available stereot…

Early Age-Related Functional Connectivity Decline in High-Order Cognitive Networks Open

Tali Siman-Tov, Noam Bosak, Elliot Sprecher, Rotem Paz, Ayelet Eran , et al. · 2017

As the world ages, it becomes urgent to unravel the mechanisms underlying brain aging and find ways of intervening with them. While for decades cognitive aging has been related to localized brain changes, growing attention is now being pai…

The Organization of Mouse and Human Cortico-Hippocampal Networks Estimated by Intrinsic Functional Connectivity Open

Eyal Bergmann, Gil Zur, Guy Bershadsky, Itamar Kahn · 2016

While the hippocampal memory system has been relatively conserved across mammals, the cerebral cortex has undergone massive expansion. A central question in brain evolution is how cortical development affected the nature of cortical inputs…

Realistic Numerical and Analytical Modeling of Light Scattering in Brain Tissue for Optogenetic Applications Open

Guy Yona, Nizan Meitav, Itamar Kahn, Shy Shoham · 2016

In recent years, optogenetics has become a central tool in neuroscience research. Estimating the transmission of visible light through brain tissue is of crucial importance for controlling the activation levels of neurons in different dept…

Holographic fiber bundle system for patterned optogenetic activation of large-scale neuronal networks Open

Nairouz Farah, Alexandra Levinsky, Inbar Brosh, Itamar Kahn, Shy Shoham · 2015

Optogenetic perturbation has become a fundamental tool in controlling activity in neurons. Used to control activity in cell cultures, slice preparations, anesthetized and awake behaving animals, optical control of cell-type specific activi…

Special Section Guest Editorial: Causal Control of Biological Systems with Light Open

Christopher Moore, Itamar Kahn · 2015

“Optogenetics” is the control of cellular biophysical properties by selective, genetically targeted expression of light-sensitive moieties. This strategy has rapidly become a widely pervasive tool in neuroscience, in large part because it …

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