Itay Levin
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View article: Redirecting an anti-IL-1β antibody to bind a new, unrelated computationally predicted epitope on hIL-17A
Redirecting an anti-IL-1β antibody to bind a new, unrelated computationally predicted epitope on hIL-17A Open
HexRf is an algorithm that evaluates the potential of antibodies to bind to new epitopes. Python source code and model parameters as well as an example usage are provided.
View article: 2BarG—A program to process split Hopkinson (Kolsky) bar test results
2BarG—A program to process split Hopkinson (Kolsky) bar test results Open
2BarG is a program that analyzes Split Hopkinson (Kolsky) Pressure Bar experiments. It is Python-based and features several libraries that make processing fast, simple, and efficient with minimal operator’s intervention. The program perfor…
View article: 704 The computationally designed human antibody, AU-007, mediates human immune activation by endogenous IL-2, while uniquely breaking the IL-2 auto-inhibitory loop and preventing Treg expansion
704 The computationally designed human antibody, AU-007, mediates human immune activation by endogenous IL-2, while uniquely breaking the IL-2 auto-inhibitory loop and preventing Treg expansion Open
Background IL-2 binds two forms of IL-2 receptor: a high affinity trimeric receptor composed of CD25, CD122, and CD132, and a low affinity dimeric receptor composed of CD122 and CD132. Binding to the dimeric receptors, expressed on effecto…
View article: Increased Potency of a Bi-specific TL1A-ADAM17 (TACE) Inhibitor by Cell Surface Targeting
Increased Potency of a Bi-specific TL1A-ADAM17 (TACE) Inhibitor by Cell Surface Targeting Open
Inflammatory bowel disease (IBD) is a multifactorial disease characterized by the dysregulated activity of many pro-inflammatory factors. Thus, bi-specific inhibitors for the simultaneous inhibition of two pro-inflammatory factors can exhi…
View article: Directed evolution of a soluble human DR3 receptor for the inhibition of TL1A induced cytokine secretion
Directed evolution of a soluble human DR3 receptor for the inhibition of TL1A induced cytokine secretion Open
TNF-like 1A (TL1A) is a cytokine belonging to the TNF superfamily that promotes inflammation in autoimmune diseases. Inhibiting the interaction of TL1A with the endogenous death-domain receptor 3 (DR3) offers a therapeutic approach for tre…