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View article: Associations between telomere attrition, genetic variants in telomere maintenance genes, and non-small cell lung cancer risk in the Jammu and Kashmir population of North India
Associations between telomere attrition, genetic variants in telomere maintenance genes, and non-small cell lung cancer risk in the Jammu and Kashmir population of North India Open
Background Telomeres are repetitive DNA sequences located at the ends of chromosomes, playing a vital role in maintaining chromosomal integrity and stability. Dysregulation of telomeres has been implicated in the development of various can…
View article: Innovative in Silico Approaches for Characterization of Genes and Proteins
Innovative in Silico Approaches for Characterization of Genes and Proteins Open
Bioinformatics is an amalgamation of biology, mathematics and computer science. It is a science which gathers the information from biology in terms of molecules and applies the informatic techniques to the gathered information for understa…
View article: Genetic evaluation of the variants using MassARRAY in non-small cell lung cancer among North Indians
Genetic evaluation of the variants using MassARRAY in non-small cell lung cancer among North Indians Open
Lung cancer is genetically diverse and a major health burden. Non-small cell lung cancer (NSCLC) accounts for 80% of total lung cancer cases and 20% cases are Small cell lung cancer (SCLC). The present case–control association study focuse…
View article: Association of Genetic Variants of ELMO1 Gene With Diabetic Nephropathy in the North Indian Population
Association of Genetic Variants of ELMO1 Gene With Diabetic Nephropathy in the North Indian Population Open
Diabetic nephropathy (DN) is a major cause of renal failure globally including chronic kidney disease and end-stage renal disease (ESRD). Using comprehensive linkage disequilibrium mapping, we genotyped five polymorphisms from engulfment a…
View article: Telomere Maintenance Genes are associated with Type 2 Diabetes Susceptibility in Northwest Indian Population Group
Telomere Maintenance Genes are associated with Type 2 Diabetes Susceptibility in Northwest Indian Population Group Open
Telomere length attrition has been implicated in various complex disorders including Type 2 Diabetes (T2D). However, very few candidate gene association studies have been carried out worldwide targeting telomere maintenance genes. In the p…
View article: Novel Dual Labeled Fluorescence Probe Based Assay to Measure the Telomere Length
Novel Dual Labeled Fluorescence Probe Based Assay to Measure the Telomere Length Open
Telomeres are highly repetitive regions capping the chromosomes and composed of multiple units of hexa-nucleotides, TTAGGG, making their quantification difficult. Most of the methods developed to estimate telomeres are extensively cumberso…
View article: A Replication Study of ND3 rs2853826 association with Type 2 Diabetes in North Indian Population
A Replication Study of ND3 rs2853826 association with Type 2 Diabetes in North Indian Population Open
Type 2 Diabetes (T2D) is a complex disease and genetic is one of factor contributing to its pathogenesis. Both decreased body sensitivity to insulin and defects in insulin production are involved in T2D development. ND3 is one of the subun…
View article: MACF1 gene variant rs2296172 is associated with type 2 diabetes susceptibility in the Bania population group of Punjab - India
MACF1 gene variant rs2296172 is associated with type 2 diabetes susceptibility in the Bania population group of Punjab - India Open
Microtubule Actin Cross linking Factor 1 (MACF1) gene variant rs2296172 has been associated with Type 2 Diabetes (T2D). However, this variant has never been evaluated as such in Indian populations. We replicated this variant in pooled popu…