Itu Singh
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View article: Resistance to anti-leprosy drugs in multi-bacillary leprosy patients: The need for transformative action
Resistance to anti-leprosy drugs in multi-bacillary leprosy patients: The need for transformative action Open
Background Leprosy, caused by Mycobacterium leprae , remains a significant public health challenge, particularly in endemic regions. While multidrug therapy (MDT) has been effective, the emergence of antimicrobial resistance (AMR) to key d…
View article: Understanding Autoimmune Response Mechanisms in Leprosy
Understanding Autoimmune Response Mechanisms in Leprosy Open
Leprosy is a persistent granulomatous disease that occurs due to Mycobacterium leprae infection. Leprosy primarily affects peripheral nerves, skin, and mucous membranes. Reactions in leprosy are immunological complications that may occur a…
View article: Advancing Mycobacterium leprae transmission research: Insights from the R2STOP fund
Advancing Mycobacterium leprae transmission research: Insights from the R2STOP fund Open
Background Leprosy remains a significant public health burden in many low- and middle-income countries, with the transmission pathways of Mycobacterium leprae remaining incompletely understood. The Research to Stop Transmission of Neglecte…
View article: Investigating the role of soil-transmitted helminth infections in the development of leprosy in endemic regions
Investigating the role of soil-transmitted helminth infections in the development of leprosy in endemic regions Open
Background India alone contributes nearly 54% of the global load of new cases of leprosy and 21% to global helminthic parasitic infection cases. Research studies have suggested that Soil-transmitted helminth (STH) infection can regulate th…
View article: Morphological Index as a Sensitive Marker of Drug Resistance in Leprosy: A Case Series
Morphological Index as a Sensitive Marker of Drug Resistance in Leprosy: A Case Series Open
Resistance to antileprosy drugs is one of the main contributors for the persistence of leprosy in the present era. In the absence of universal antimicrobial resistance (AMR) surveillance through the national program, the indications for re…
View article: Genomic characterization of Mycobacterium lepromatosis from ENL patients from India
Genomic characterization of Mycobacterium lepromatosis from ENL patients from India Open
These results provide valuable insights into the prevalence of M. lepromatosis in ENL patients in different regions of India and contribute to our understanding of the genetic characteristics of this pathogen in the context of leprosy.
View article: Case Report: An Atypical Case of Post-Kala-Azar Dermal Leishmaniasis with Ulcers and Verrucous Lesions: Clinical and Therapeutic Implications
Case Report: An Atypical Case of Post-Kala-Azar Dermal Leishmaniasis with Ulcers and Verrucous Lesions: Clinical and Therapeutic Implications Open
About 75% cases of post-kala-azar dermal leishmaniasis (PKDL) occur in India. Although the classic description of PKDL is the progression from initial hypopigmented macular lesions to papules to plaques and nodular lesions, atypical morpho…
View article: Assessment of Clinical, Histopathological, and Bacteriological Findings in Treated Leprosy Patients with Persistent Skin Lesions: A Retrospective Cohort Study
Assessment of Clinical, Histopathological, and Bacteriological Findings in Treated Leprosy Patients with Persistent Skin Lesions: A Retrospective Cohort Study Open
Since the introduction of multidrug therapy (MDT), various disabilities/morbidities due to leprosy have been prevented. However, there is a subset of patients in whom the skin lesions do not resolve completely or remain unchanged despite a…
View article: High frequency of ofloxacin resistance patterns of Mycobacterium leprae from India: An indication to revisit second line anti-leprosy treatment regimen
High frequency of ofloxacin resistance patterns of Mycobacterium leprae from India: An indication to revisit second line anti-leprosy treatment regimen Open
The occurrence of resistance to the current multidrug therapy regimen (specifically dapsone and rifampicin) and to ofloxacin, a secondary antileprosy medication in M. leprae, represents a concerning scenario. This calls for an expansion to…
View article: Effective amelioration of the Lucio phenomenon with adjuvant tofacitinib therapy in a patient with dual infection of Mycobacterium leprae and Mycobacterium lepromatosis: a case report from India
Effective amelioration of the Lucio phenomenon with adjuvant tofacitinib therapy in a patient with dual infection of Mycobacterium leprae and Mycobacterium lepromatosis: a case report from India Open
Introduction. The Lucio phenomenon (LP) is a characteristic reaction pattern seen in patients with diffuse lepromatous leprosy (DLL). Dual infection with Mycobacterium leprae and Mycobacterium lepromatosis in DLL has been confirmed from ot…
View article: Effective amelioration of lucio phenomenon with adjuvant tofacitinib therapy in a patient with dual infection of M. leprae and M. lepromatosis: A case report from India.
Effective amelioration of lucio phenomenon with adjuvant tofacitinib therapy in a patient with dual infection of M. leprae and M. lepromatosis: A case report from India. Open
Introduction: Lucio phenomenon (LP) is characteristic reaction pattern seen in patient of diffuse lepromatous leprosy(DLL). Dual infection of M. leprae and M. lepromatosis in case of DLL is confirmed from other endemic country but same is …
View article: Type 2 reaction associated sensorineural hearing loss in a drug resistant lepromatous leprosy patient: A case report
Type 2 reaction associated sensorineural hearing loss in a drug resistant lepromatous leprosy patient: A case report Open
Rationale: Leprosy, a chronic granulomatous disease often present clinically as erythema nodosum leprosum, a type 2 reaction. The involvement of cochlear part of audiovestibular system is a rarity. Patient concerns: A 26-year-old male pati…
View article: Reviewer response for version 1
Reviewer response for version 1 Open
Introduction: Lucio phenomenon (LP) is characteristic reaction pattern seen in patient of diffuse lepromatous leprosy(DLL). Dual infection of M. leprae and M. lepromatosis in case of DLL is confirmed from other endemic country but sam…
View article: Editorial: Modern molecular era of the mycobacterial world: Insights into diagnosis and transmission of mycobacteria and associated diseases
Editorial: Modern molecular era of the mycobacterial world: Insights into diagnosis and transmission of mycobacteria and associated diseases Open
EDITORIAL article Front. Trop. Dis, 22 March 2023Sec. Major Tropical Diseases Volume 4 - 2023 | https://doi.org/10.3389/fitd.2023.1182754
View article: Diagnosis of Leprosy: Current Updates and Future Directions
Diagnosis of Leprosy: Current Updates and Future Directions Open
Leprosy is a chronic infectious granulomatous disorder caused by Mycobacterium leprae , chiefly affecting skin and peripheral nerves. It is the only known bacteria to infect nerves. Clinical diagnosis of leprosy is made when any of the thr…
View article: Corroboration of cross-reactivity between Mycobacterium leprae and hosts’ salivary and cutaneous proteins: A hope for prognostic biomarkers for the pathogenesis of reactions in leprosy
Corroboration of cross-reactivity between Mycobacterium leprae and hosts’ salivary and cutaneous proteins: A hope for prognostic biomarkers for the pathogenesis of reactions in leprosy Open
Introduction Immunological reactions are frequent complications that may occur either before, during, or after treatment and affect 30–50% of leprosy patients. The presence of autoantibodies like rheumatoid factor, antinuclear factor, and …
View article: Efficacy of fixed duration multidrug therapy for the treatment of multibacillary leprosy: A prospective observational study from Northern India
Efficacy of fixed duration multidrug therapy for the treatment of multibacillary leprosy: A prospective observational study from Northern India Open
Background: In endemic regions of several countries, the prevalence of leprosy has not come down to the level of elimination. On the contrary, new cases are being detected in large numbers. Clinically, it is frequently noted that despite c…
View article: Existence of viable Mycobacterium leprae in natural environment and its genetic profiling in a leprosy endemic region
Existence of viable Mycobacterium leprae in natural environment and its genetic profiling in a leprosy endemic region Open
Introduction Molecular epidemiology of leprosy is very important to study leprosy transmission dynamics and to enhance our understanding of leprosy in endemic areas by utilizing the molecular typing method. Nowadays our understanding of le…
View article: High Prevalence of Resistance to Anti-Leprosy Drugs in Leprosy Cases with Chronic Erythema Nodosum Leprosum
High Prevalence of Resistance to Anti-Leprosy Drugs in Leprosy Cases with Chronic Erythema Nodosum Leprosum Open
Sir, The World Health Organization (WHO) Global Leprosy strategy: 2021-2030 “towards zero leprosy” aims for a leprosy-free world with an emphasis on early and adequate treatment.[1] At the national level, substantial work is done to detect…
View article: Effective amelioration of lucio phenomenon with adjuvant tofacitinib therapy in a patient with dual infection of M. leprae and M. lepromatosis : A case report from India.
Effective amelioration of lucio phenomenon with adjuvant tofacitinib therapy in a patient with dual infection of M. leprae and M. lepromatosis : A case report from India. Open
Introduction: Lucio phenomenon (LP) is characteristic reaction pattern seen in patient of diffuse lepromatous leprosy(DLL). Dual infection of M. leprae and M. lepromatosis in case of DLL is confirmed from other endemic country but same is …
View article: Mimicking B and T cell epitopes between Mycobacterium leprae and host as predictive biomarkers in type 1 reaction in leprosy
Mimicking B and T cell epitopes between Mycobacterium leprae and host as predictive biomarkers in type 1 reaction in leprosy Open
Several Mycobacterial infections including leprosy and tuberculosis are known to evoke autoimmune responses by modulating homeostatic mechanism of the host. Presence of autoantibodies like, rheumatoid factor, anti-nuclear factor and antibo…
View article: Drug Resistance in Mycobacterium Leprae in the Context of Zero Leprosy
Drug Resistance in Mycobacterium Leprae in the Context of Zero Leprosy Open
Leprosy is a chronic infectious disease caused by Mycobacterium leprae and/or by Mycobacterium lepromatosis.[12] The disease mainly affects the peripheral nerves, skin, and mucous membranes and if left untreated it may lead to nerve damage…
View article: Appropriately Selected Nerve in Suspected Leprous Neuropathy Yields High Positive Results for Mycobacterium leprae DNA by Polymerase Chain Reaction Method
Appropriately Selected Nerve in Suspected Leprous Neuropathy Yields High Positive Results for Mycobacterium leprae DNA by Polymerase Chain Reaction Method Open
Identification of Mycobacterium leprae DNA by polymerase chain reaction (PCR) is a reliable and an affordable method to confirm leprosy. DNA from 87 nerve samples (61 from paraffin blocks and 26 fresh samples) was extracted. Mycobacterium …
View article: Neuroimaging in leprosy: The nerves and beyond
Neuroimaging in leprosy: The nerves and beyond Open
To elucidate the spectrum of findings on neuroimaging in leprosy with special reference to magnetic resonance imaging (MRI). We retrospectively reviewed the neuroimaging findings on MRI in thirty-two patients with leprosy where dedicated p…
View article: Evidence for Mycobacterium leprae Drug Resistance in a Large Cohort of Leprous Neuropathy Patients from India
Evidence for Mycobacterium leprae Drug Resistance in a Large Cohort of Leprous Neuropathy Patients from India Open
Resistance to anti-leprosy drugs is on the rise. Several studies have documented resistance to rifampicin, dapsone, and ofloxacin in patients with leprosy. We looked for point mutations within the folP1, rpoB, and gyrA gene regions of the …