Iva Marković
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View article: <i>In silico</i>design of stable single-domain antibodies with high affinity
<i>In silico</i>design of stable single-domain antibodies with high affinity Open
Antibody-based therapeutics have become indispensable in modern medicine, but traditional methods of antibody discovery often present with limitations in developability, cross-reactivity, and ethical concerns. While deep learning and gener…
View article: Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9)
Structural basis for the mechanism and antagonism of receptor signaling mediated by Interleukin-9 (IL-9) Open
Interleukin-9 (IL-9) is the hallmark cytokine in Th9 immunity and is also central to Innate Lymphocyte 2 (ILC2) biology. Furthermore, receptor signaling mediated by IL-9 has been linked to inflammatory and autoimmune diseases, and cancer. …
View article: Mechanism of receptor assembly via the pleiotropic adipokine Leptin
Mechanism of receptor assembly via the pleiotropic adipokine Leptin Open
The adipokine Leptin activates its type I cytokine receptor (LEP-R) in the hypothalamus to regulate body weight and exerts additional pleiotropic functions in immunity, fertility, and cancer. However, the structure and mechanism of Leptin-…
View article: Robust de novo design of protein binding proteins from target structural information alone
Robust de novo design of protein binding proteins from target structural information alone Open
The design of proteins that bind to a specific site on the surface of a target protein using no information other than the three-dimensional structure of the target remains an outstanding challenge. We describe a general solution to this p…
View article: Modulation of Signaling Mediated by TSLP and IL-7 in Inflammation, Autoimmune Diseases, and Cancer
Modulation of Signaling Mediated by TSLP and IL-7 in Inflammation, Autoimmune Diseases, and Cancer Open
Thymic Stromal Lymphopoietin (TSLP) and Interleukin-7 (IL-7) are widely studied cytokines within distinct branches of immunology. On one hand, TSLP is crucially important for mediating type 2 immunity at barrier surfaces and has been linke…