Ivaine Taís Sauthier Sartor
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View article: Differentially Expressed Genes in Oral Cavity and Thyroide Cancer: An In Silico Approach with GEO and TCGA Data
Differentially Expressed Genes in Oral Cavity and Thyroide Cancer: An In Silico Approach with GEO and TCGA Data Open
Head and neck cancer comprises several pathologies occurring at distinct sites above the clavicle. Due to their anatomical position, these types of cancer may cause additional physical, physiological and psychosocial impairments. Early det…
View article: High prevalence of 19A pneumococcal serotype carriage during the COVID-19 pandemic in Brazil
High prevalence of 19A pneumococcal serotype carriage during the COVID-19 pandemic in Brazil Open
19A serotype, as well other most frequent serotypes identified are not covered by the PCV-10 in a community setting where PCV-10 is widely available. This finding reinforces the need for continuous surveillance to determine the impact of p…
View article: Long-term reduced functional capacity and quality of life in hospitalized COVID-19 patients
Long-term reduced functional capacity and quality of life in hospitalized COVID-19 patients Open
Background Persistent symptoms and exercise intolerance have been reported after COVID-19, even months after the acute disease. Although, the long-term impact on exercise capacity and health-related quality of life (HRQoL) is still unclear…
View article: Identification of novel biomarkers with potential for diagnosis and prognosis of gastric cancer: a Bioinformatics Approach
Identification of novel biomarkers with potential for diagnosis and prognosis of gastric cancer: a Bioinformatics Approach Open
Introduction: Gastric cancer (GC) is the fifth most diagnosed neoplasia and the third leading cause of cancer-related deaths. A substantial number of patients exhibit an advanced GC stage once diagnosed. Therefore, the search for biomarker…
View article: Diagnostic accuracy of a SARS-CoV-2 rapid test and optimal time for seropositivity according to the onset of symptoms
Diagnostic accuracy of a SARS-CoV-2 rapid test and optimal time for seropositivity according to the onset of symptoms Open
Point-of-care serological tests for SARS-CoV-2 have been used for COVID-19 diagnosis. However, their accuracy over time regarding the onset of symptoms is not fully understood. We aimed to assess the accuracy of a point-of-care lateral flo…
View article: C-Gemis: A computational tool for gene expression data analysis for gastric cancer
C-Gemis: A computational tool for gene expression data analysis for gastric cancer Open
Background: Computational tools dedicated to the analysis of transcripts microarray and RNA-seq can provide an instrument to search biomarkers related to diagnosis and prognosis in different neoplasia. This process is carried out by automa…
View article: Primary cells derived from Tuberous Sclerosis Complex patients show autophagy alteration in the haploinsufficiency state
Primary cells derived from Tuberous Sclerosis Complex patients show autophagy alteration in the haploinsufficiency state Open
Tuberous sclerosis complex (TSC) is an autosomal dominant cancer predisposition disorder caused by heterozygous mutations in TSC1 or TSC2 genes and characterized by mTORC1 hyperactivation. TSC-associated tumors develop after loss of hetero…
View article: Association between obesity and hospitalization in mild COVID-19 adult outpatients in Brazil: a prospective cohort study
Association between obesity and hospitalization in mild COVID-19 adult outpatients in Brazil: a prospective cohort study Open
Objective: To evaluate the association between obesity and hospitalization in mild COVID-19 adult outpatients in Brazil. Subjects and methods: Adults with signs and symptoms suggestive of acute SARS-CoV-2 infection who sought treatment in …
View article: Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses
Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses Open
COVID-19 manifests as a milder disease in children than adults, but the underlying mechanisms are not fully characterized. Here we assess the difference in cellular or humoral immune responses of pediatric and adult COVID-19 patients to se…
View article: Children Have Similar Reverse Transcription Polymerase Chain Reaction Cycle Threshold for Severe Acute Respiratory Syndrome Coronavirus 2 in Comparison With Adults
Children Have Similar Reverse Transcription Polymerase Chain Reaction Cycle Threshold for Severe Acute Respiratory Syndrome Coronavirus 2 in Comparison With Adults Open
Background: The viral dynamics and the role of children in the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not completely understood. Our aim was to evaluate reverse transcription polymerase chain reaction (R…
View article: Clinical and molecular characterization of patients fulfilling Chompret criteria for Li-Fraumeni syndrome in Southern Brazil
Clinical and molecular characterization of patients fulfilling Chompret criteria for Li-Fraumeni syndrome in Southern Brazil Open
Li-Fraumeni syndrome (LFS) is an autosomal dominant cancer predisposition syndrome caused by pathogenic germline variants in the TP53 gene, characterized by a predisposition to the development of a broad spectrum of tumors at an early age.…
View article: Y380Q novel mutation in receptor-binding domain of SARS-CoV-2 spike protein together with C379W interfere in the neutralizing antibodies interaction
Y380Q novel mutation in receptor-binding domain of SARS-CoV-2 spike protein together with C379W interfere in the neutralizing antibodies interaction Open
Background The emergence of SARS-CoV-2 variants is a current public health concern possibly impacting COVID-19 disease diagnosis, transmission patterns and vaccine effectiveness. Objectives To describe the SARS-CoV-2 lineages circulating e…
View article: The use of micro-costing in an economic analysis of allogeneic HSCT in Brazil
The use of micro-costing in an economic analysis of allogeneic HSCT in Brazil Open
Objective: The objective of this study was to estimate treatment costs of Hematopoietic stem cell transplantation (HSCT) at a reference center in Brazil. Methods: The study population consisted of patients from the Unified Health System HS…
View article: Association between obesity and hospitalization in mild COVID-19 young adult outpatients in Brazil: a prospective cohort study
Association between obesity and hospitalization in mild COVID-19 young adult outpatients in Brazil: a prospective cohort study Open
Background/Objectives The aim of this study was to evaluate the association between obesity and hospitalization in mild COVID-19 adult outpatients in Brazil. Subjects/Methods Adults with signs and symptoms suggestive of acute SARS-CoV-2 in…
View article: Strong specific anti-viral responses in pediatric COVID-19 patients in South Brazil
Strong specific anti-viral responses in pediatric COVID-19 patients in South Brazil Open
Epidemiological evidence that COVID-19 manifests as a milder disease in children compared to adults has been reported by numerous studies, but the mechanisms underlying this phenomenon have not been characterized. It is still unclear how f…
View article: Children have similar RT-PCR cycle threshold for SARS-CoV-2 in comparison with adults
Children have similar RT-PCR cycle threshold for SARS-CoV-2 in comparison with adults Open
Background The viral dynamics and the role of children in the spread of SARS-CoV-2 are not completely understood. Our aim was to evaluate RT-PCR Ct values among children with confirmed SARS-CoV-2 compared with that of adult subjects. Metho…
View article: Strong anti-viral responses in pediatric COVID-19 patients in South Brazil
Strong anti-viral responses in pediatric COVID-19 patients in South Brazil Open
Epidemiological evidence that COVID-19 manifests as a milder disease in children compared to adults has been reported by numerous studies, but the mechanisms underlying this phenomenon have not been characterized. It is still unclear how f…
View article: Absence of detection of RSV and influenza during the COVID-19 pandemic in a Brazilian cohort: Likely role of lower transmission in the community
Absence of detection of RSV and influenza during the COVID-19 pandemic in a Brazilian cohort: Likely role of lower transmission in the community Open
Measures to reduce SARS-CoV-2 transmission likely exerted a huge impact in the spread of alternate respiratory pathogens. These findings contribute to the knowledge about the dynamics of virus spread. Further, it may be considered for guid…
View article: Primary cells derived from Tuberous Sclerosis Complex patients show autophagy alteration in the haploinsufficiency state
Primary cells derived from Tuberous Sclerosis Complex patients show autophagy alteration in the haploinsufficiency state Open
Tuberous sclerosis complex (TSC) is an autosomal dominant cancer predisposition disorder caused by heterozygous mutations in TSC1 or TSC2 genes and characterized by mTORC1 hyperactivation. TSC-associated tumors develop after loss of hetero…
View article: Desensitization for hematopoietic stem cell transplantation: Case report
Desensitization for hematopoietic stem cell transplantation: Case report Open
Purpose: The presence of anti-human leukocyte antigen (HLA) antibodies has been correlated with graft failure in organ and tissue transplantation, demonstrating the importance of screening for antibodies before transplant. The purpose of t…
View article: TULP3: A potential biomarker in colorectal cancer?
TULP3: A potential biomarker in colorectal cancer? Open
Colorectal cancer (CRC) is the second most common cancer in women and the third most common cancer in men globally. The identification of differentially expressed genes associated to patient's clinical data may represent a useful approach …