Iván Ballesteros
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View article: Tumor-initiating stem cells fine-tune the plasticity of neutrophils to sculpt a protective niche
Tumor-initiating stem cells fine-tune the plasticity of neutrophils to sculpt a protective niche Open
The heterogeneous nature of tumor-associated neutrophils (TANs) has been recognized, but how different cell states of TANs emerge, evolve, distribute, and impact cancer immunotherapy efficacy remain elusive. Using single-cell RNA sequencin…
View article: Circadian Control of Neutrophils Drives Collateral Perfusion and Stroke Outcome
Circadian Control of Neutrophils Drives Collateral Perfusion and Stroke Outcome Open
BACKGROUND: Stroke remains a leading cause of mortality and disability, driven by complex, time-dependent mechanisms that aggravate ischemic injury. Collateral perfusion dictates infarct size, expansion rate, and penumbral preservation, ye…
View article: Tumor-Initiating Cells Fine-tune the Plasticity of Neutrophils to Sculpt a Protective Niche
Tumor-Initiating Cells Fine-tune the Plasticity of Neutrophils to Sculpt a Protective Niche Open
The abundant accumulation of neutrophils in various solid cancers has been well recognized, but the functions of tumor-associated neutrophils (TANs) remain controversial. TANs have long been believed to be immune suppressive and have thus …
View article: Circadian Modulation of Neutrophil Function Determines Collateral Perfusion and Outcome After Ischemic Stroke
Circadian Modulation of Neutrophil Function Determines Collateral Perfusion and Outcome After Ischemic Stroke Open
Stroke is a leading cause of mortality and disability, driven by complex and time-dependent mechanisms that aggravate ischemic damage. Among them, collateral perfusion determines the initial size of the ischemic core, the rate of its expan…
View article: Zfp263 is a transcriptional checkpoint of neutrophil development
Zfp263 is a transcriptional checkpoint of neutrophil development Open
During development neutrophils undergo extensive changes in nuclear morphology, gene expression programmes, and acquire specific effector functions. However, molecular mechanisms controlling neutrophil development remain largely unknown. H…
View article: Deterministic reprogramming of neutrophils within tumors
Deterministic reprogramming of neutrophils within tumors Open
Neutrophils are increasingly recognized as key players in the tumor immune response and are associated with poor clinical outcomes. Despite recent advances characterizing the diversity of neutrophil states in cancer, common trajectories an…
View article: Neutrophils in cancer, a love–hate affair
Neutrophils in cancer, a love–hate affair Open
Neutrophils dominate the immunological landscape of multiple types of solid tumours in mice and humans and exert different pro‐ or antitumoral activity. This functional heterogeneity has prompted a search for different subsets and classifi…
View article: Combined statistical modeling enables accurate mining of circadian transcription
Combined statistical modeling enables accurate mining of circadian transcription Open
Circadian-regulated genes are essential for tissue homeostasis and organismal function, and are therefore common targets of scrutiny. Detection of rhythmic genes using current analytical tools requires exhaustive sampling, a demand that is…
View article: Role of TLR4 (Toll-Like Receptor 4) in N1/N2 Neutrophil Programming After Stroke
Role of TLR4 (Toll-Like Receptor 4) in N1/N2 Neutrophil Programming After Stroke Open
Background and Purpose— After stroke, the population of infiltrated neutrophils in the brain is heterogeneous, including a population of alternative neutrophils (N2) that express M2 phenotype markers. We explored the role of TLR4 (toll-lik…
View article: Neutrophils instruct homeostatic and pathological states in naive tissues
Neutrophils instruct homeostatic and pathological states in naive tissues Open
Immune protection relies on the capacity of neutrophils to infiltrate challenged tissues. Naive tissues, in contrast, are believed to remain free of these cells and protected from their toxic cargo. Here, we show that neutrophils are endow…
View article: Myeloid cells as therapeutic targets in neuroinflammation after stroke: Specific roles of neutrophils and neutrophil–platelet interactions
Myeloid cells as therapeutic targets in neuroinflammation after stroke: Specific roles of neutrophils and neutrophil–platelet interactions Open
Ischemic brain injury causes a local inflammatory response, involving the activation of resident brain cells such as microglia and the recruitment of infiltrating immune cells. Increasing evidence supports that plasticity of the myeloid ce…
View article: Specification of tissue-resident macrophages during organogenesis
Specification of tissue-resident macrophages during organogenesis Open
INTRODUCTION Embryonic development and tissue homeostasis depend on cooperation between specialized cell types. Resident macrophages are professional phagocytes that survey their surroundings; eliminate unfit cells, microorganisms, and met…
View article: Efficacy and safety evaluation of nilotinib and dasatinib (2G -TKI) on first line treatment in 73 patients with CML-CP outside of clinical trials. Andalusian CML registry (RALMC)
Efficacy and safety evaluation of nilotinib and dasatinib (2G -TKI) on first line treatment in 73 patients with CML-CP outside of clinical trials. Andalusian CML registry (RALMC) Open
Even though they were approved last June 2011 to be used on first line, it is not a common procedure to begin treatment of CML-CP with 2GTKI, despite it has been demonstrated its efficacy and safety against imatinib
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View article: The Kynurenine Pathway in the Acute and Chronic Phases of Cerebral Ischemia
The Kynurenine Pathway in the Acute and Chronic Phases of Cerebral Ischemia Open
Kynurenines are a wide range of catabolites which derive from tryptophan through the "Kynurenine Pathway" (KP). In addition to its peripheral role, increasing evidence shows a role of the KP in the central nervous system (CNS), mediating b…