Ivan Moiseev
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View article: Cytokine release syndrome following chimeric antigen receptor T-cell therapy: Pathophysiology, clinical manifestations, and novel therapeutic approaches
Cytokine release syndrome following chimeric antigen receptor T-cell therapy: Pathophysiology, clinical manifestations, and novel therapeutic approaches Open
Introduction . The introduction of chimeric antigen receptor (CAR) T-cell therapy into clinical practice has transformed international treatment standards for B-cell leukemias, lymphomas, and multiple myeloma. Alongside its high antitumor …
View article: VENETOCLAX-BASED VERSUS 7+3 INDUCTION THERAPY IN FIT YOUNGER ADULTS WITH NEWLY DIAGNOSED NON-CBF AML
VENETOCLAX-BASED VERSUS 7+3 INDUCTION THERAPY IN FIT YOUNGER ADULTS WITH NEWLY DIAGNOSED NON-CBF AML Open
Objective: Venetoclax-based regimens have emerged as a standard therapeutic option for newly diagnosed Acute Myeloid Leukemia (AML) in patients deemed unfit for intensive chemotherapy. However, the efficacy of venetoclax in fit patients re…
View article: Сравнительная оценка долгосрочных результатов трансплантации аллогенных гемопоэтических стволовых клеток от неродственных доноров из российской и международной баз данных при заболеваниях системы крови
Сравнительная оценка долгосрочных результатов трансплантации аллогенных гемопоэтических стволовых клеток от неродственных доноров из российской и международной баз данных при заболеваниях системы крови Open
BACKGROUND. In recent years, the number of allogeneic hematopoietic stem cell transplantations (allo-HSCT) has continued to rise due to the ongoing improvement of transplantation technologies and rapid growth of bone marrow donor registrie…
View article: An ASTCT, CIBMTR, EBMT, and APBMT Consensus Statement Defining Response Criteria for Hematopoietic Cell Transplantation Associated Thrombotic Microangiopathy (TA-TMA) Directed Therapy
An ASTCT, CIBMTR, EBMT, and APBMT Consensus Statement Defining Response Criteria for Hematopoietic Cell Transplantation Associated Thrombotic Microangiopathy (TA-TMA) Directed Therapy Open
The consensus response criteria proposed by this expert panel are a step towards standardizing the assessment of treatment responses of TA-TMA directed agents for future studies and interventional clinical trials. Adoption of these criteri…
View article: Daratumumab for PRCA after HCT: study and practical considerations from the EBMT Transplant Complications Working Party
Daratumumab for PRCA after HCT: study and practical considerations from the EBMT Transplant Complications Working Party Open
Pure red cell aplasia (PRCA) is a relevant complication after ABO-mismatched allogeneic hematopoietic cell transplantation (HCT). No standard treatment exists, and practice is heterogenous. In this study, we took advantage of an internatio…
View article: GVHD prophylaxis in matched related stem cell transplantation: Why post-transplant cyclophosphamide can be recommended a study by the EBMT transplant complications working party
GVHD prophylaxis in matched related stem cell transplantation: Why post-transplant cyclophosphamide can be recommended a study by the EBMT transplant complications working party Open
Rabbit anti-thymocyte globulin (rATG) reduced chronic GVHD after matched related donor (MRD) allogeneic stem cell transplantation (alloSCT) from 69% to 32% in a randomized trial and is the recommended standard in Europe. Post-transplantati…
View article: Time course of organ and hematological response to complement blockage in transplant-associated thrombotic microangiopathy after allogeneic hematopoietic stem cell transplantation
Time course of organ and hematological response to complement blockage in transplant-associated thrombotic microangiopathy after allogeneic hematopoietic stem cell transplantation Open
Background Hematopoietic stem cell transplantation (HSCT) offers a potential cure for various hematologic malignancies and non-malignant disorders but is often accompanied by severe complications, one of the most challenging being transpla…
View article: How to reduce the risk of primary engraftment failure after haploidentical hematopoietic stem cell transplantation in patients with acute myeloid leukemia?
How to reduce the risk of primary engraftment failure after haploidentical hematopoietic stem cell transplantation in patients with acute myeloid leukemia? Open
Background. Haploidentical hematopoietic stem cell transplantation (haplo‑HSCT) represents an important alternative for patients with acute myeloid leukemia (AML) who lack an HLA‑matched donor. However, the high incidence of primary graft …
View article: Targeted therapy of newly diagnosed FLT3-mutated acute myeloid leukemia. A single-center ambispective cohort study
Targeted therapy of newly diagnosed FLT3-mutated acute myeloid leukemia. A single-center ambispective cohort study Open
Background. FMS‑like tyrosine kinase 3 (FLT3) gene mutations are the most frequently detected genetic aberrations in adult patients with newly diagnosed acute myeloid leukemia (AML), identified in approximately 30 % of patients. The additi…
View article: Development of a preclinical model of myeloid tumors with high immune checkpoints expression
Development of a preclinical model of myeloid tumors with high immune checkpoints expression Open
Background . Myelodysplastic syndrome is a group of malignant blood diseases with a high risk of transformation into acute myeloid leukemia. One treatment approach is to target immune checkpoints (ICs) that are overexpressed on tumor cells…
View article: Basic Molecular Biology, Metabolic and Immunological Mechanisms of Fecal Microbiota Transplantation
Basic Molecular Biology, Metabolic and Immunological Mechanisms of Fecal Microbiota Transplantation Open
Aim: demonstration of basic molecular biological, metabolic and immunological effects of fecal microbiota transplantation (FMT), on the example of a rare case of acute graft-versus-host disease (GVHD) with intestinal damage in a patient af…
View article: Correction: ECP versus ruxolitinib in steroid-refractory chronic GVHD – a retrospective study by the EBMT transplant complications working party
Correction: ECP versus ruxolitinib in steroid-refractory chronic GVHD – a retrospective study by the EBMT transplant complications working party Open
View article: Prognosis of patients with Hodgkin lymphoma and indeterminate response to PD-1 inhibitor therapy: considerations for application of LYRIC criteria in real clinical practice
Prognosis of patients with Hodgkin lymphoma and indeterminate response to PD-1 inhibitor therapy: considerations for application of LYRIC criteria in real clinical practice Open
PD-1 inhibitors have shown unconventional response patterns in classic Hodgkin lymphoma (cHL). These include the phenomenon of pseudoprogression, highlighting the need for specialized response criteria such as the LyRIC, which stringened d…
View article: Difficulties of primary diagnosis in patients with suspected systemic mastocytosis
Difficulties of primary diagnosis in patients with suspected systemic mastocytosis Open
Background. Mastocytosis is a rare myeloproliferative disease based on clonal hematopoiesis of mast cells, with accumulation of mast cells in various tissues and organs. The cutaneous mastocytosis is common in the pediatric population and,…
View article: Prevalence of fungal DNAemia mediated by putatively non-pathogenic fungi in immunocompromised patients with febrile neutropenia: a prospective cohort study
Prevalence of fungal DNAemia mediated by putatively non-pathogenic fungi in immunocompromised patients with febrile neutropenia: a prospective cohort study Open
Invasive fungal disease (IFD) presents a life-threatening condition in immunocompromised patients, thus often prompting empirical administration of antifungal treatment, without adequate mycological evidence. Over the past years, wide use …
View article: Time-Dependent Shifts in Intestinal Bacteriome, Klebsiella Colonization and Incidence of Antibiotic-Resistance Genes after Allogeneic Hematopoietic Stem Cell Transplantation
Time-Dependent Shifts in Intestinal Bacteriome, Klebsiella Colonization and Incidence of Antibiotic-Resistance Genes after Allogeneic Hematopoietic Stem Cell Transplantation Open
Dose-intensive cytostatic therapy and antibiotic treatment in allogeneic hematopoietic stem cell transplantation (allo-HSCT) cause severe abnormalities in a composition of gut microbiota as well as the emergence of antibiotic resistance. T…
View article: Unrelated donor transplantation with posttransplant cyclophosphamide vs ATG for myelodysplastic neoplasms
Unrelated donor transplantation with posttransplant cyclophosphamide vs ATG for myelodysplastic neoplasms Open
It has been reported in prospective randomized trials that antithymocyte globulin (ATG)–based graft-versus-host disease (GVHD) prophylaxis has benefits in the setting of allogeneic hematopoietic stem cell transplantation (allo-HSCT) with u…
View article: Влияние поражения сердца на прогноз у пациентов с системным AL-амилоидозом
Влияние поражения сердца на прогноз у пациентов с системным AL-амилоидозом Open
AIM. To assess the clinical features as well as the factors affecting prognosis and long-term treatment outcomes in systemic AL amyloidosis patients with cardiac involvement. MATERIALS & METHODS. The trial enrolled 123 systemic AL amyloido…
View article: How risky is a second allogeneic stem cell transplantation?
How risky is a second allogeneic stem cell transplantation? Open
There is no consensus on second allogeneic stem cell transplantation (alloSCT) indications in patients with hematologic malignancies relapsing after a first alloSCT. In historic publications, a very high non-relapse mortality (NRM) has bee…
View article: Safety, Feasibility, and Advantages of Oral Microbiota Transplantation: The First Clinical Case
Safety, Feasibility, and Advantages of Oral Microbiota Transplantation: The First Clinical Case Open
The pilot clinical study presented demonstrates the possibility, safety, and effectiveness of oral microbiota transplantation from a healthy donor to a patient with neuroblastoma to prevent chemotherapy-induced oral mucositis. A 6-month-ol…
View article: Management of complications of chimeric antigen receptor T-cell therapy: a report by the European Society of Blood and Marrow Transplantation
Management of complications of chimeric antigen receptor T-cell therapy: a report by the European Society of Blood and Marrow Transplantation Open
CAR-T cells are in standard clinical use to treat relapsed or refractory hematologic malignancies, such as non-Hodgkin’s lymphoma, multiple myeloma and acute lymphoblastic leukemia. Owing to the rapidly progressing field of CAR-T cell ther…
View article: Atranorin is a novel potential candidate drug for treating myelodysplastic syndrome
Atranorin is a novel potential candidate drug for treating myelodysplastic syndrome Open
This work is devoted to the study of biocompatibility, cyto- and genotoxicity, mechanism of action and prospects for the use of atranorin, which is an AKT kinase inhibitor, for the treatment of myelodysplastic syndrome. Atranorin was isola…
View article: Ксенотрансплантация гемопоэтических стволовых клеток человека мышам линии NBSGW: базовая модель для доклинической разработки подходов генной терапии
Ксенотрансплантация гемопоэтических стволовых клеток человека мышам линии NBSGW: базовая модель для доклинической разработки подходов генной терапии Open
Background. The gene therapy based on hematopoietic cell xenotransplantation is becoming a powerful and universally applied therapeutic strategy in an ever-expanding range of human diseases. One of the current issues in implementing the te…
View article: Daratumumab in post-transplantation pure red cell aplasia in adults
Daratumumab in post-transplantation pure red cell aplasia in adults Open
Post-transplant pure red cell aplasia (PRCA) is a rare complication that occurs after allogeneic hematopoietic stem cell transplantation (allo-HSCT) with ABO incompatibility.In most cases, this condition resolves without any treatment.Howe…
View article: Stroke before hematopoietic stem cell transplantation is a possible risk factor for post-transplant adverse outcomes
Stroke before hematopoietic stem cell transplantation is a possible risk factor for post-transplant adverse outcomes Open
More than 50,000 hematopoietic stem cell transplants (HSCT) are performed annually in the world for blood malignancies, solid tumors, aplastic anemia, primary immunodeficiency, autoimmune and metabolic diseases.Stroke occurs in 3% of patie…
View article: ATG or post-transplant cyclophosphamide to prevent GVHD in matched unrelated stem cell transplantation?
ATG or post-transplant cyclophosphamide to prevent GVHD in matched unrelated stem cell transplantation? Open
There is a high risk of GVHD and non-relapse mortality (NRM) after allogeneic stem cell transplantations (alloSCT) from unrelated donors. Prophylaxis with rabbit anti-thymocyte globulin (rATG) is standard in Europe but post-transplantation…
View article: PTCy versus ATG as graft-versus-host disease prophylaxis in mismatched unrelated stem cell transplantation
PTCy versus ATG as graft-versus-host disease prophylaxis in mismatched unrelated stem cell transplantation Open
View article: ECP versus ruxolitinib in steroid-refractory chronic GVHD – a retrospective study by the EBMT transplant complications working party
ECP versus ruxolitinib in steroid-refractory chronic GVHD – a retrospective study by the EBMT transplant complications working party Open
View article: Endothelial Activation and Stress Index (EASIX) to predict mortality after allogeneic stem cell transplantation: a prospective study
Endothelial Activation and Stress Index (EASIX) to predict mortality after allogeneic stem cell transplantation: a prospective study Open
Background We previously reported that the “Endothelial Activation and Stress Index” (EASIX; ((creatinine×lactate dehydrogenase)÷thrombocytes)) measured before start of conditioning predicts mortality after allogeneic hematopoietic stem ce…
View article: Heterozygous mutation of the CCR5 gene in HIV-infected individuals with lymphomas
Heterozygous mutation of the CCR5 gene in HIV-infected individuals with lymphomas Open
The chemokine receptor CCR5, encoded by appropriate gene, is expressed by CD4+ cells, being a membrane co-receptor for HIV-1.Homozygous carriers of CCR5 mutation (CCR5-Δ32 deletion) are resistant to HIV-1 infection.The heterozygous mutatio…